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Hypoxic brain damage after intramuscular self-injection of diclofenac for acute back pain

We present a case of hypoxic brain damage that occurred after intramuscular injection of diclofenac due to a severe anaphylactic reaction. A 38-year-old nurse treated herself for acute lower back pain with 100 mg diclofenac intramuscularly. Five minutes later, she collapsed and developed coma and re...

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Bibliographische Detailangaben
Hauptverfasser: Schäbitz, Wolf-Rüdiger (VerfasserIn) , Berger, Christian (VerfasserIn) , Knauth, Michael (VerfasserIn) , Meinck, Hans-Michael (VerfasserIn) , Steiner, Thorsten (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2001
In: European journal of anaesthesiology
Year: 2001, Jahrgang: 18, Heft: 11, Pages: 763-765
ISSN:1365-2346
DOI:10.1046/j.1365-2346.2001.00913.x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2346.2001.00913.x
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/european-journal-of-anaesthesiology/article/abs/hypoxic-brain-damage-after-intramuscular-selfinjection-of-diclofenac-for-acute-back-pain/3E8B1C75CCC298E66F4F26C856F3FAFE
Volltext
Verfasserangaben:W.R. Schäbitz, C. Berger, M. Knauth, H.M. Meinck and T. Steiner
Beschreibung
Zusammenfassung:We present a case of hypoxic brain damage that occurred after intramuscular injection of diclofenac due to a severe anaphylactic reaction. A 38-year-old nurse treated herself for acute lower back pain with 100 mg diclofenac intramuscularly. Five minutes later, she collapsed and developed coma and respiratory arrest. After cardiopulmonary resuscitation she was transferred to hospital. On admission she was comatose and received controlled ventilation of the lungs. Magnetic resonance imaging and computerized tomography showed signs of hypoxic brain injury and the patient died from central cardiopulmonary failure 7 days later. Intramuscular treatment with non-steroidal anti-inflammatory drugs such as diclofenac has rare but potentially severe side-effects. Therefore, intramuscular injections are inappropriate and should be replaced with oral or rectal treatment, which has similar absorption profiles.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe
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Beschreibung:Online Resource
ISSN:1365-2346
DOI:10.1046/j.1365-2346.2001.00913.x

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