C-FLIPR, a new regulator of death receptor-induced apoptosis
c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA level; so far only two of them, c-FLIPL and c-FLIPS, had been found to be expressed at the protein level. In this report,...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
|
| In: |
The journal of biological chemistry
Year: 2005, Jahrgang: 280, Heft: 15, Pages: 14507-14513 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M414425200 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.M414425200 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021925820659658 
|
| Verfasserangaben: | Alexander Golks, Dirk Brenner, Cornelius Fritsch, Peter H. Krammer, and Inna N. Lavrik |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1750422352 | ||
| 003 | DE-627 | ||
| 005 | 20230904182820.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210304s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1074/jbc.M414425200 |2 doi | |
| 035 | |a (DE-627)1750422352 | ||
| 035 | |a (DE-599)KXP1750422352 | ||
| 035 | |a (OCoLC)1341397043 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Golks, Alexander |e VerfasserIn |0 (DE-588)1228356793 |0 (DE-627)1750122766 |4 aut | |
| 245 | 1 | 0 | |a C-FLIPR, a new regulator of death receptor-induced apoptosis |c Alexander Golks, Dirk Brenner, Cornelius Fritsch, Peter H. Krammer, and Inna N. Lavrik |
| 246 | 3 | 3 | |a c-FLIP R, a new regulator of death receptor-induced apoptosis |
| 264 | 1 | |c 2005 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 4 January 2021 | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe | ||
| 500 | |a Im Titel ist das "R" bei c-FLIP tiefgestellt | ||
| 500 | |a Gesehen am 04.03.2021 | ||
| 520 | |a c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA level; so far only two of them, c-FLIPL and c-FLIPS, had been found to be expressed at the protein level. In this report, we reveal the endogenous expression of a third isoform of c-FLIP. We demonstrate its presence in a number of T and B cell lines as well as in primary human T cells. We identified this isoform as c-FLIPR, a death effector domain-only splice variant previously identified on the mRNA level. Impor-/tantly, c-FLIPR is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex upon CD95 stimulation. Several properties of c-FLIPR are similar to c-FLIPS: both isoforms have a short half-life, a similar pattern of expression during activation of primary human T cells, and are strongly induced in T cells upon CD3/CD28 costimulation. Taken together, our data demonstrate endogenous expression of c-FLIPR and similar roles of c-FLIPR and c-FLIPS isoforms in death receptor-mediated apoptosis. | ||
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 700 | 1 | |a Lavrik, Inna N. |e VerfasserIn |0 (DE-588)107529312X |0 (DE-627)833293869 |0 (DE-576)443375232 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of biological chemistry |d [Amsterdam] : Elsevier B.V., 1905 |g 280(2005), 15 vom: 15. Apr., Seite 14507-14513 |h Online-Ressource |w (DE-627)269247025 |w (DE-600)1474604-9 |w (DE-576)077883837 |x 1083-351X |7 nnas |a C-FLIPR, a new regulator of death receptor-induced apoptosis |
| 773 | 1 | 8 | |g volume:280 |g year:2005 |g number:15 |g day:15 |g month:04 |g pages:14507-14513 |g extent:7 |a C-FLIPR, a new regulator of death receptor-induced apoptosis |
| 856 | 4 | 0 | |u https://doi.org/10.1074/jbc.M414425200 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0021925820659658 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210304 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 107529312X |a Lavrik, Inna N. |m 107529312X:Lavrik, Inna N. |d 50000 |e 50000PL107529312X |k 0/50000/ |p 5 |y j | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 4 | ||
| 998 | |g 1228356793 |a Golks, Alexander |m 1228356793:Golks, Alexander |d 50000 |e 50000PG1228356793 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1750422352 |e 3881659293 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Alexander Golks, Dirk Brenner, Cornelius Fritsch, Peter H. Krammer, and Inna N. Lavrik"]},"id":{"doi":["10.1074/jbc.M414425200"],"eki":["1750422352"]},"origin":[{"dateIssuedDisp":"2005","dateIssuedKey":"2005"}],"relHost":[{"note":["Gesehen am 19.05.2021"],"disp":"C-FLIPR, a new regulator of death receptor-induced apoptosisThe journal of biological chemistry","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"269247025","corporate":[{"display":"American Society for Biochemistry and Molecular Biology","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"pubHistory":["1.1905/06 -"],"part":{"extent":"7","volume":"280","text":"280(2005), 15 vom: 15. Apr., Seite 14507-14513","issue":"15","pages":"14507-14513","year":"2005"},"titleAlt":[{"title":"JBC online"},{"title":"JBC"}],"title":[{"subtitle":"JBC","title":"The journal of biological chemistry","title_sort":"journal of biological chemistry"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. by the American Society for Biochemistry and Molecular Biology"]},"origin":[{"publisherPlace":"[Amsterdam] ; Baltimore, Md. [u.a.] ; Bethesda, Md.","publisher":"Elsevier B.V. ; American Soc. of Biological Chemists ; ASBMB Publications","dateIssuedKey":"2021","dateIssuedDisp":"2021-"}],"id":{"eki":["269247025"],"zdb":["1474604-9"],"issn":["1083-351X"]}}],"physDesc":[{"extent":"7 S."}],"person":[{"family":"Golks","given":"Alexander","roleDisplay":"VerfasserIn","display":"Golks, Alexander","role":"aut"},{"display":"Krammer, Peter H.","roleDisplay":"VerfasserIn","role":"aut","family":"Krammer","given":"Peter H."},{"given":"Inna N.","family":"Lavrik","role":"aut","roleDisplay":"VerfasserIn","display":"Lavrik, Inna N."}],"title":[{"title_sort":"C-FLIPR, a new regulator of death receptor-induced apoptosis","title":"C-FLIPR, a new regulator of death receptor-induced apoptosis"}],"language":["eng"],"recId":"1750422352","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Available online 4 January 2021","Elektronische Reproduktion der Druck-Ausgabe","Im Titel ist das \"R\" bei c-FLIP tiefgestellt","Gesehen am 04.03.2021"],"titleAlt":[{"title":"c-FLIP R, a new regulator of death receptor-induced apoptosis"}]} | ||
| SRT | |a GOLKSALEXACFLIPRANEW2005 | ||