Cutting edge: in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death
CD4+CD25+FoxP3+ regulatory T cells (Treg) suppress T cell function and protect rodents from autoimmune disease. Regulation of Treg during an immune response is of major importance. Enhanced survival of Treg is beneficial in autoimmune disease, whereas increased depletion by apoptosis is advantageous...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 21, 2005
|
| In: |
The journal of immunology
Year: 2005, Jahrgang: 175, Heft: 1, Pages: 32-36 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.175.1.32 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.175.1.32 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/175/1/32 
|
| Verfasserangaben: | Benedikt Fritzsching, Nina Oberle, Nadine Eberhardt, Sabine Quick, Jürgen Haas, Brigitte Wildemann, Peter H. Krammer, and Elisabeth Suri-Payer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1750425572 | ||
| 003 | DE-627 | ||
| 005 | 20230427140038.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210304s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.175.1.32 |2 doi | |
| 035 | |a (DE-627)1750425572 | ||
| 035 | |a (DE-599)KXP1750425572 | ||
| 035 | |a (OCoLC)1341397098 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Fritzsching, Benedikt |d 1974- |e VerfasserIn |0 (DE-588)124900518 |0 (DE-627)367769778 |0 (DE-576)294559000 |4 aut | |
| 245 | 1 | 0 | |a Cutting edge |b in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death |c Benedikt Fritzsching, Nina Oberle, Nadine Eberhardt, Sabine Quick, Jürgen Haas, Brigitte Wildemann, Peter H. Krammer, and Elisabeth Suri-Payer |
| 246 | 3 | 3 | |a In contrast to effector T cells, CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death |
| 246 | 3 | 3 | |a In contrast to effector T cells, CD4+ CD25+ FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death |
| 264 | 1 | |c June 21, 2005 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel sind die Pluszeichen bei "CD4", "CD25" und "FoxP3" hochgestellt | ||
| 500 | |a Gesehen am 04.03.2021 | ||
| 520 | |a CD4+CD25+FoxP3+ regulatory T cells (Treg) suppress T cell function and protect rodents from autoimmune disease. Regulation of Treg during an immune response is of major importance. Enhanced survival of Treg is beneficial in autoimmune disease, whereas increased depletion by apoptosis is advantageous in cancer. We show here that freshly isolated FACS-sorted Treg are highly sensitive toward CD95-mediated apoptosis, whereas other T cell populations are resistant to CD95-induced apoptosis shortly after isolation. In contrast, TCR restimulation of Treg in vitro revealed a reduced sensitivity toward activation-induced cell death compared with CD4+CD25− T cells. Thus, the apoptosis phenotype of Treg is unique in comparison to other T cells, and this might be further explored for novel therapeutic modulations of Treg. | ||
| 700 | 1 | |a Haas, Jürgen |e VerfasserIn |0 (DE-588)1073216810 |0 (DE-627)828662290 |0 (DE-576)434731749 |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 700 | 1 | |a Suri-Payer, Elisabeth |e VerfasserIn |0 (DE-588)1228564159 |0 (DE-627)1750407353 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 175(2005), 1 vom: 1. Juli, Seite 32-36 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Cutting edge in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death |
| 773 | 1 | 8 | |g volume:175 |g year:2005 |g number:1 |g day:1 |g month:07 |g pages:32-36 |g extent:5 |a Cutting edge in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.175.1.32 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jimmunol.org/content/175/1/32 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210304 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 1228564159 |a Suri-Payer, Elisabeth |m 1228564159:Suri-Payer, Elisabeth |d 50000 |e 50000PS1228564159 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 7 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |d 50000 |e 910000PW110203844 |e 911100PW110203844 |e 50000PW110203844 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 6 | ||
| 998 | |g 1073216810 |a Haas, Jürgen |m 1073216810:Haas, Jürgen |d 910000 |d 911100 |e 910000PH1073216810 |e 911100PH1073216810 |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 124900518 |a Fritzsching, Benedikt |m 124900518:Fritzsching, Benedikt |d 910000 |d 911460 |e 910000PF124900518 |e 911460PF124900518 |k 0/910000/ |k 1/910000/911460/ |p 1 |x j | ||
| 999 | |a KXP-PPN1750425572 |e 3881763597 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2005","dateIssuedDisp":"June 21, 2005"}],"relHost":[{"origin":[{"publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedKey":"2025","publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md.","dateIssuedDisp":"2025-"}],"note":["Gesehen am 18.08.2025"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"269535217","disp":"Cutting edge in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell deathThe journal of immunology","corporate":[{"display":"American Association of Immunologists","role":"isb"}],"pubHistory":["1.1916 -"],"name":{"displayForm":["American Association of Immunologists"]},"part":{"volume":"175","year":"2005","issue":"1","text":"175(2005), 1 vom: 1. Juli, Seite 32-36","extent":"5","pages":"32-36"},"id":{"eki":["269535217"],"issn":["1550-6606"],"zdb":["1475085-5"]}}],"person":[{"display":"Fritzsching, Benedikt","role":"aut","given":"Benedikt","family":"Fritzsching"},{"display":"Haas, Jürgen","family":"Haas","role":"aut","given":"Jürgen"},{"family":"Wildemann","given":"Brigitte","role":"aut","display":"Wildemann, Brigitte"},{"display":"Krammer, Peter H.","family":"Krammer","role":"aut","given":"Peter H."},{"given":"Elisabeth","role":"aut","family":"Suri-Payer","display":"Suri-Payer, Elisabeth"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Im Titel sind die Pluszeichen bei \"CD4\", \"CD25\" und \"FoxP3\" hochgestellt","Gesehen am 04.03.2021"],"title":[{"title_sort":"Cutting edge","title":"Cutting edge","subtitle":"in contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death"}],"physDesc":[{"extent":"5 S."}],"recId":"1750425572","name":{"displayForm":["Benedikt Fritzsching, Nina Oberle, Nadine Eberhardt, Sabine Quick, Jürgen Haas, Brigitte Wildemann, Peter H. Krammer, and Elisabeth Suri-Payer"]},"titleAlt":[{"title":"In contrast to effector T cells, CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death"},{"title":"In contrast to effector T cells, CD4+ CD25+ FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death"}],"id":{"eki":["1750425572"],"doi":["10.4049/jimmunol.175.1.32"]}} | ||
| SRT | |a FRITZSCHINCUTTINGEDG2120 | ||