NF-κB synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells
IL-4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgE-dependent allergic inflammatory diseases. Expression of IL-4 in differentiated Th2 cells is regulated by transcription factors such as NF-AT, AP-1 and NF-IL6. Recently, increasing evidence in...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 March 2004
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| In: |
European journal of immunology
Year: 2004, Jahrgang: 34, Heft: 4, Pages: 1111-1118 |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.200324687 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/eji.200324687 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.200324687 
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| Verfasserangaben: | Min Li‐Weber, Marco Giaisi, Sven Baumann, Katalin Pálfi and Peter H. Krammer |
MARC
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| 520 | |a IL-4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgE-dependent allergic inflammatory diseases. Expression of IL-4 in differentiated Th2 cells is regulated by transcription factors such as NF-AT, AP-1 and NF-IL6. Recently, increasing evidence indicates that the pro-inflammatory transcription factor NF-κB may also participate inIL-4 expression. In this study, we show that the IL-4 promoter is synergistically activated by NF-κB, NF-AT and NF-IL6 at the NF-κB/NF-AT/NF-IL6 composite sites. In addition, we performed the chromatin immunoprecipitation technique to determine the functional relevance of NF-κB in the activation of the IL-4 gene in vivo. We demonstrate that NF-κB binds to the IL-4 promoter in vivo upon T cell activation. Inhibition of NF-κB nuclear translocation in living cells blocked binding of NF-κB to the IL-4 promoter. The data provide first evidence that NF-κB is directly involved in IL-4 transcription. | ||
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