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Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

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Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS_NBL) emerged as a distinct pediatric brain tumor entity fr...

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Main Authors: Korshunov, Andrey (Author) , Okonechnikov, Konstantin (Author) , Schmitt-Hoffner, Felix (Author) , Ryzhova, Marina (Author) , Sahm, Felix (Author) , Stichel, Damian (Author) , Schrimpf, Daniel (Author) , Reuss, David (Author) , Sievers, Philipp (Author) , Suwala, Abigail Kora (Author) , Jones, David T. W. (Author) , Pfister, Stefan (Author) , Kool, Marcel (Author) , Deimling, Andreas von (Author)
Format: Article (Journal)
Language:English
Published: 03 February 2021
In: Acta Neuropathologica Communications
Year: 2021, Volume: 9, Pages: 1-12
ISSN:2051-5960
DOI:10.1186/s40478-021-01118-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s40478-021-01118-5
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Author Notes:Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David E. Reuss, Philipp Sievers, Abigail Kora Suwala, Ella Kumirova, Olga Zheludkova, Andrey Golanov, David T.W. Jones, Stefan M. Pfister, Marcel Kool and Andreas von Deimling
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