Case report: anti-Coa in a Co-(a+)-typed patient with chronic renal insufficiency
The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) Chapter/Article |
| Language: | English |
| Published: |
1997
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| In: |
Beiträge zur Infusionstherapie und Transfusionsmedizin
Year: 1997, Volume: 34, Pages: 185-189 |
| Online Access: |
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| Author Notes: | A. Leo, J.P. Cartron, M. Strittmatter, G. Rowe, D. Roelcke |
MARC
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| 245 | 1 | 0 | |a Case report |b anti-Coa in a Co-(a+)-typed patient with chronic renal insufficiency |c A. Leo, J.P. Cartron, M. Strittmatter, G. Rowe, D. Roelcke |
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| 520 | |a The recently identified molecular structure of the Colton blood group system is characterized by an amino acid substitution at position 45 (Colton a: alanine, Colton b: valine) of the archetypical water channel protein Aquaporin-1 (AQP1), which regulates water homeostasis in the erythrocyte membrane and in the proximal tubule of the nephron. We identified a patient with the unique constellation of an antibody with the specificity anti-Coa and the Co (a+) phenotype. The serological antigen typing was confirmed by molecular typing with PCR-RFLP. The antibody has to be interpreted as an antibody against a partial Colton a antigen or as an autoantibody despite a negative direct antiglobulin test (DAT). The patient is suffering from chronic renal insufficiency of unknown origin, rising speculation about a pathophysiological relationship between the serological constellation and the clinical disease under the aspect of localization of the Colton antigens on AQP1. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aquaporin 1 | |
| 650 | 4 | |a Aquaporins | |
| 650 | 4 | |a Blood Group Antigens | |
| 650 | 4 | |a Blood Grouping and Crossmatching | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Ion Channels | |
| 650 | 4 | |a Isoantibodies | |
| 650 | 4 | |a Kidney Failure, Chronic | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Phenotype | |
| 650 | 4 | |a Renal Dialysis | |
| 700 | 1 | |a Cartron, J. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strittmatter, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rowe, G. |e VerfasserIn |4 aut | |
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