Enhancement of Sia-lb1 antigenicity by sulphur-containing substituents at C-5 of free N-acetylneuraminic acid
The Sia-lb1 epitope, recognized by anti-Sia-lb1 cold agglutinins, is unique since it is represented by the alpha-N-acetylneuraminic acid (alpha NeuNAc) monosaccharide. Chemical modifications of the chain at C-5 of alpha NeuNAc have shown that the natural 2-carbon and the artificial 3-carbon chains a...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
1997
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| In: |
Beiträge zur Infusionstherapie und Transfusionsmedizin
Year: 1997, Jahrgang: 34, Pages: 215-219 |
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| Verfasserangaben: | D. Roelcke, A. Leo, R. Brossmer |
MARC
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| 245 | 1 | 0 | |a Enhancement of Sia-lb1 antigenicity by sulphur-containing substituents at C-5 of free N-acetylneuraminic acid |c D. Roelcke, A. Leo, R. Brossmer |
| 264 | 1 | |c 1997 | |
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| 520 | |a The Sia-lb1 epitope, recognized by anti-Sia-lb1 cold agglutinins, is unique since it is represented by the alpha-N-acetylneuraminic acid (alpha NeuNAc) monosaccharide. Chemical modifications of the chain at C-5 of alpha NeuNAc have shown that the natural 2-carbon and the artificial 3-carbon chains are optimal for anti-Sia-lb1 binding. Sia-lb1 antigenicity of alpha NeuNAc could be tenfold enhanced by replacement of the carbonyl oxygen by sulphur. The structural requirements of the Sia-lb1 epitope for optimal antibody binding were identified. | ||
| 650 | 4 | |a Agglutinins | |
| 650 | 4 | |a Amino Acid Substitution | |
| 650 | 4 | |a Amino Acids, Sulfur | |
| 650 | 4 | |a Binding Sites, Antibody | |
| 650 | 4 | |a Cryoglobulins | |
| 650 | 4 | |a Epitopes | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Isoantigens | |
| 650 | 4 | |a N-Acetylneuraminic Acid | |
| 650 | 4 | |a Structure-Activity Relationship | |
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