C332C genotype of glyoxalase 1 and its association with late diabetic complications: Glo1 genotype and diabetic neuropathy
<p>Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes. Here, we examine a possible association of a single nucleotide polymorphism of gly...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17. Juni 2013
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| In: |
Experimental and clinical endocrinology & diabetes
Year: 2013, Jahrgang: 121, Heft: 7, Pages: 436-439 |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/s-0033-1345124 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/s-0033-1345124 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1345124 
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| Verfasserangaben: | J.B. Groener, P. Reismann, T. Fleming, H. Kalscheuer, D. Lehnhoff, A. Hamann, P. Roser, A. Bierhaus, P.P. Nawroth, G. Rudofsky |
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| 245 | 1 | 0 | |a C332C genotype of glyoxalase 1 and its association with late diabetic complications |b Glo1 genotype and diabetic neuropathy |c J.B. Groener, P. Reismann, T. Fleming, H. Kalscheuer, D. Lehnhoff, A. Hamann, P. Roser, A. Bierhaus, P.P. Nawroth, G. Rudofsky |
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| 520 | |a <p>Glyoxalase 1 catalyses the detoxification of methylglyoxal, a major precursor of advanced glycation end products associated with aging, neurodegenerative diseases, and microvascular complications of diabetes. Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes.</p> <p>Genotyping was performed in 209 patients with type 1 and 524 patients with type 2 diabetes using polymerase chain reaction and subsequent cleavage by restriction endonuclease Bsa I.</p> <p>Frequencies of the glyoxalase 1 genotypes were different with respect to diabetes type with a significantly higher prevalence of A332A-genotype in type 1 diabetes (35.9% vs. 27.3%; p=0.03). In type 1 diabetes, there was no correlation of any genotype with diabetic retinopathy, nephropathy or neuropathy. In contrast, type 2 diabetic patients homozygous for the C332C allele showed a significantly increased prevalence of diabetic neuropathy (p=0.03; OR=1.49 [95%-CI: 1.04; 2.11]), while no association with diabetic nephropathy or retinopathy was found. However, the significance of this association was lost after correction for multiple testing.</p> <p>Our data suggest a possible association of C332C-genotype of the glyoxalase 1 gene with diabetic neuropathy in type 2 diabetes, supporting the hypothesis that methylglyoxal might be an important mediator of diabetic neuropathy in type 2 diabetes.</p> | ||
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