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Magnetization transfer measurements in normal-appearing cerebral white matter in patients with chronic obstructive hydrocephalus

Purpose: The purpose of this work was to assess the presence of subtle changes in normal-appearing white matter on T2-weighted MR images in patients with chronic obstructive hydrocephalus using magnetization transfer (MT) measurements. - Method: In 12 patients with chronic obstructive hydrocephalus,...

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Bibliographic Details
Main Authors: Hähnel, Stefan (Author) , Münkel, Kristin (Author) , Jansen, Olav (Author) , Heiland, Sabine (Author) , Reidel, Margot (Author) , Freund, Michael (Author) , Aschoff, Alfred (Author) , Sartor, Klaus (Author)
Format: Article (Journal)
Language:English
Published: July 1999
In: Journal of computer assisted tomography
Year: 1999, Volume: 23, Issue: 4, Pages: 516-520
ISSN:1532-3145
Online Access:Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/jcat/Fulltext/1999/07000/Magnetization_Transfer_Measurements_in.4.aspx
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Author Notes:Stefan Hähnel, Kristin Münkel, Olav Jansen, Sabine Heiland, Margot Reidel, Michael Freund, Alfred Aschoff, Klaus Sartor
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Summary:Purpose: The purpose of this work was to assess the presence of subtle changes in normal-appearing white matter on T2-weighted MR images in patients with chronic obstructive hydrocephalus using magnetization transfer (MT) measurements. - Method: In 12 patients with chronic obstructive hydrocephalus, MT ratios (MTRs) of normal-appearing rostral (PR) and caudal (PC) periventricular white matter, of the genu (CG) and the splenium (CS) of the corpus callosum, and of the thalamus (TH) were measured and compared with those of 16 healthy control subjects. - Results: We found a significantly lower MTR in chronic obstructive hydrocephalus than in the normal group for PR, PC, CG, and CS but not for TH. - Conclusion: Our study shows that MT measurements give additional information that cannot be gained by conventional SE MRI, suggesting that chronic obstructive hydrocephalus is associated with diffuse white matter damage that also affects normal-appearing cerebral white matter.
Item Description:Gesehen am 11.03.2021
Physical Description:Online Resource
ISSN:1532-3145

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