Iodixanol in cerebral computed tomography: a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol
Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 1999
|
| In: |
European radiology
Year: 1999, Volume: 9, Issue: 7, Pages: 1362-1365 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s003300050849 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s003300050849
|
| Author Notes: | A. Doerfler, J. Fiebach, I. Wanke, M. Forsting, P. Henseke, K. Sartor |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1751131629 | ||
| 003 | DE-627 | ||
| 005 | 20220819133346.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210311s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s003300050849 |2 doi | |
| 035 | |a (DE-627)1751131629 | ||
| 035 | |a (DE-599)KXP1751131629 | ||
| 035 | |a (OCoLC)1341398410 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dörfler, Arnd |d 1968- |e VerfasserIn |0 (DE-588)114656797 |0 (DE-627)521900832 |0 (DE-576)289804221 |4 aut | |
| 245 | 1 | 0 | |a Iodixanol in cerebral computed tomography |b a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol |c A. Doerfler, J. Fiebach, I. Wanke, M. Forsting, P. Henseke, K. Sartor |
| 264 | 1 | |c August 1999 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.03.2021 | ||
| 520 | |a Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographic efficacy during cerebral CT. One hundred adult patients scheduled to undergo contrast-enhanced cerebral CT were randomly allocated to receive either iodixanol or iohexol. All completed the trial. Safety was evaluated by recording discomfort and other adverse events, tolerance by assessing intensity and incidence of discomfort. Radiographic efficacy was assessed from the diagnostic information and the radiographic density. No serious adverse events occurred. One patient (2 %) in the iodixanol group and one patient (2 %) in the iohexol group experienced a transient reddening at the neck and lower neck-line, respectively. Both contrast agents were well tolerated. One patient (2 %) in the iodixanol group and two patients (4 %) in the iohexol group experienced a sensation of warmth (discomfort) in connection with the injection. No difference between the two contrast media were noted radiographically. This comparison between iodixanol and iohexol showed both contrast media to be safe, well-tolerated and efficacious for use in cerebral CT. | ||
| 700 | 1 | |a Fiebach, Jochen Benedikt |d 1969- |e VerfasserIn |0 (DE-588)121764702 |0 (DE-627)705645282 |0 (DE-576)292872577 |4 aut | |
| 700 | 1 | |a Wanke, Isabel |d 1965- |e VerfasserIn |0 (DE-588)120473704 |0 (DE-627)08069716X |0 (DE-576)179155997 |4 aut | |
| 700 | 1 | |a Forsting, Michael |d 1960- |e VerfasserIn |0 (DE-588)111509696 |0 (DE-627)503026824 |0 (DE-576)289704561 |4 aut | |
| 700 | 1 | |a Henseke, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sartor, Klaus |d 1941- |e VerfasserIn |0 (DE-588)108446743 |0 (DE-627)559460325 |0 (DE-576)289613000 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European radiology |d Berlin : Springer, 1991 |g 9(1999), 7, Seite 1362-1365 |h Online-Ressource |w (DE-627)268757526 |w (DE-600)1472718-3 |w (DE-576)103868070 |x 1432-1084 |7 nnas |a Iodixanol in cerebral computed tomography a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol |
| 773 | 1 | 8 | |g volume:9 |g year:1999 |g number:7 |g pages:1362-1365 |g extent:4 |a Iodixanol in cerebral computed tomography a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s003300050849 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210311 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 108446743 |a Sartor, Klaus |m 108446743:Sartor, Klaus |d 910000 |d 911100 |e 910000PS108446743 |e 911100PS108446743 |k 0/910000/ |k 1/910000/911100/ |p 6 |y j | ||
| 998 | |g 121764702 |a Fiebach, Jochen Benedikt |m 121764702:Fiebach, Jochen Benedikt |d 910000 |d 911400 |e 910000PF121764702 |e 911400PF121764702 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 999 | |a KXP-PPN1751131629 |e 3884774646 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 11.03.2021"],"id":{"eki":["1751131629"],"doi":["10.1007/s003300050849"]},"relHost":[{"language":["eng"],"part":{"issue":"7","text":"9(1999), 7, Seite 1362-1365","pages":"1362-1365","year":"1999","volume":"9","extent":"4"},"title":[{"subtitle":"official organ of the European Association of Radiology","title_sort":"European radiology","title":"European radiology"}],"pubHistory":["1.1991 -"],"titleAlt":[{"title":"European radiology / Supplement"},{"title":"European radiology supplements"}],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"European Association of Radiology"}],"origin":[{"dateIssuedKey":"1991","publisherPlace":"Berlin ; Heidelberg","publisher":"Springer","dateIssuedDisp":"1991-"}],"recId":"268757526","note":["Gesehen am 06.02.2018","Ungezählte Beil.: Supplement"],"id":{"issn":["1432-1084","1613-3757"],"zdb":["1472718-3"],"eki":["268757526"]},"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Iodixanol in cerebral computed tomography a randomized, double-blind, phase-III, parallel study with iodixanol and iohexolEuropean radiology"}],"language":["eng"],"recId":"1751131629","name":{"displayForm":["A. Doerfler, J. Fiebach, I. Wanke, M. Forsting, P. Henseke, K. Sartor"]},"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"August 1999"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"4 S."}],"person":[{"role":"aut","given":"Arnd","roleDisplay":"VerfasserIn","display":"Dörfler, Arnd","family":"Dörfler"},{"family":"Fiebach","display":"Fiebach, Jochen Benedikt","role":"aut","given":"Jochen Benedikt","roleDisplay":"VerfasserIn"},{"family":"Wanke","display":"Wanke, Isabel","roleDisplay":"VerfasserIn","given":"Isabel","role":"aut"},{"role":"aut","given":"Michael","roleDisplay":"VerfasserIn","display":"Forsting, Michael","family":"Forsting"},{"display":"Henseke, P.","family":"Henseke","roleDisplay":"VerfasserIn","given":"P.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Klaus","family":"Sartor","display":"Sartor, Klaus"}],"title":[{"title_sort":"Iodixanol in cerebral computed tomography","title":"Iodixanol in cerebral computed tomography","subtitle":"a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol"}]} | ||
| SRT | |a DOERFLERARIODIXANOLI1999 | ||