Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort
Background Aim of this study was to evaluate the predictors of hs-cTnT in a non-ACS patient cohort admitted to the emergency department. Hypothesis Atrial fibrillation and hypertension may not always be sufficient for elevation for hs-cTnT. Methods We performed a retrospective, single center study e...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 July 2018
|
| In: |
Clinical cardiology
Year: 2018, Volume: 41, Issue: 8, Pages: 1055-1061 |
| ISSN: | 1932-8737 |
| DOI: | 10.1002/clc.23026 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/clc.23026 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23026 
|
| Author Notes: | Manfred Berger, Meryem Emir, Tanja Brünnler, Felix Rockmann, Ralf Lehmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1751134229 | ||
| 003 | DE-627 | ||
| 005 | 20220819133437.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210311s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/clc.23026 |2 doi | |
| 035 | |a (DE-627)1751134229 | ||
| 035 | |a (DE-599)KXP1751134229 | ||
| 035 | |a (OCoLC)1341398572 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Berger, Manfred |d 1985- |e VerfasserIn |0 (DE-588)1066279683 |0 (DE-627)817179119 |0 (DE-576)425729931 |4 aut | |
| 245 | 1 | 0 | |a Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort |c Manfred Berger, Meryem Emir, Tanja Brünnler, Felix Rockmann, Ralf Lehmann |
| 264 | 1 | |c 17 July 2018 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.03.2021 | ||
| 520 | |a Background Aim of this study was to evaluate the predictors of hs-cTnT in a non-ACS patient cohort admitted to the emergency department. Hypothesis Atrial fibrillation and hypertension may not always be sufficient for elevation for hs-cTnT. Methods We performed a retrospective, single center study encompassing in total 1003 patients. Individuals were retrospectively divided in ACS- and non-ACS patients by two independent investigators reviewing the medical records. In order to identify predictors of hs-cTnT elevation hazard ratios were calculated for age, gender, vital signs, cardiovascular risk factors, LVEF, serum levels of CRP, hemoglobin, and creatinine. Elevation of hs-cTnT was defined by exceeding 14 ng/L (upper reference limit [URL]). Results About 987 patients were included while 25 patients were excluded because of missing data. 307 patients (31.4%) met the current guideline requirements of diagnosing an ACS, whereas 671 patients (68.6%) were hospitalized with excluded ACS. In the multivariate analysis age, anemia, CRP, creatinine, and reduced systolic left ventricular ejection fraction were independent predictors of elevated troponin T levels in the non-ACS group. However, hypertensive systolic blood pressure, atrial fibrillation and tachycardia were not predictive for Troponin T elevation in non-ACS patients in this multivariate analysis. Conclusions In an unselected, non-ACS patient cohort age, chronic renal failure, inflammatory state, and reduced left ventricular systolic function were associated with hs-cTnT levels above the upper reference limit. Rather, often supposed predictors as atrial fibrillation, hypertension, and tachycardia cannot sufficiently explain increased hs-cTnT in our study. Hence, further studies are needed to assess whether isolated hypertension, tachycardia, or atrial fibrillation sufficiently explain elevated hs-cTnT. | ||
| 650 | 4 | |a acute coronary syndrome | |
| 650 | 4 | |a atrial fibrillation | |
| 650 | 4 | |a cardiac troponin T | |
| 650 | 4 | |a emergency patient cohort | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a predictors | |
| 700 | 1 | |a Lehmann, Ralf |d 1972- |e VerfasserIn |0 (DE-588)122892151 |0 (DE-627)082218609 |0 (DE-576)293466394 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical cardiology |d Weinheim [u.a.] : Wiley, 1978 |g 41(2018), 8, Seite 1055-1061 |h Online-Ressource |w (DE-627)329369237 |w (DE-600)2048223-1 |w (DE-576)102475989 |x 1932-8737 |7 nnas |a Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort |
| 773 | 1 | 8 | |g volume:41 |g year:2018 |g number:8 |g pages:1055-1061 |g extent:7 |a Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort |
| 856 | 4 | 0 | |u https://doi.org/10.1002/clc.23026 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23026 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210311 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 122892151 |a Lehmann, Ralf |m 122892151:Lehmann, Ralf |d 60000 |d 61000 |e 60000PL122892151 |e 61000PL122892151 |k 0/60000/ |k 1/60000/61000/ |p 5 |y j | ||
| 999 | |a KXP-PPN1751134229 |e 3884781235 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Manfred Berger, Meryem Emir, Tanja Brünnler, Felix Rockmann, Ralf Lehmann"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"17 July 2018"}],"id":{"eki":["1751134229"],"doi":["10.1002/clc.23026"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"title":[{"title":"Clinical cardiology","subtitle":"official journal of the American Society for Preventive Cardiology","title_sort":"Clinical cardiology"}],"note":["Gesehen am 05.09.19"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohortClinical cardiology","language":["eng"],"recId":"329369237","pubHistory":["1.1978 -"],"part":{"year":"2018","pages":"1055-1061","issue":"8","volume":"41","text":"41(2018), 8, Seite 1055-1061","extent":"7"},"origin":[{"publisherPlace":"Weinheim [u.a.] ; Mahwah, NJ","dateIssuedKey":"1978","publisher":"Wiley ; Clinical Cardiology Publ.","dateIssuedDisp":"1978-"}],"id":{"doi":["10.1002/(ISSN)1932-8737"],"eki":["329369237"],"zdb":["2048223-1"],"issn":["1932-8737"]},"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","display":"Berger, Manfred","roleDisplay":"VerfasserIn","given":"Manfred","family":"Berger"},{"display":"Lehmann, Ralf","roleDisplay":"VerfasserIn","role":"aut","family":"Lehmann","given":"Ralf"}],"title":[{"title":"Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort","title_sort":"Non-coronary predictors of elevated high-sensitive cardiac troponin T (hs-cTnT) levels in an unselected emergency patient cohort"}],"note":["Gesehen am 11.03.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1751134229"} | ||
| SRT | |a BERGERMANFNONCORONAR1720 | ||