Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?
A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 February 2021
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| In: |
Arthritis Research & Therapy
Year: 2021, Volume: 23, Pages: 1-15 |
| ISSN: | 1465-9913 |
| DOI: | 10.1186/s13075-021-02437-7 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13075-021-02437-7
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| Author Notes: | Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz and Lars-Oliver Tykocinski |
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| 520 | |a A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the metabolism of SF. Thus, this study investigates the effect of Th cells on the glucose metabolism and phenotype of SF and how this is influenced by the blockade of cytokines, janus kinases (JAKs) and glycolysis. | ||
| 650 | 4 | |a Fibroblast-like synoviocytes | |
| 650 | 4 | |a Glycolysis | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Janus kinases | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a Rheumatoid arthritis | |
| 650 | 4 | |a Synovial fibroblasts | |
| 650 | 4 | |a T helper cells | |
| 650 | 4 | |a T lymphocytes | |
| 650 | 4 | |a Translational research | |
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