The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice
In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages. It has been suggested that hepcidin suppression is controlled by growth...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
Haematologica, the hematology journal
Year: 2013, Jahrgang: 98, Heft: 3, Pages: 444-447 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2012.069807 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2012.069807 Verlag, lizenzpflichtig, Volltext: https://haematologica.org/article/view/6599 
|
| Verfasserangaben: | Guillem Casanovas, Maja Vujić Spasić, Carla Casu, Stefano Rivella, Jens Strelau, Klaus Unsicker, and Martina U. Muckenthaler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1751222640 | ||
| 003 | DE-627 | ||
| 005 | 20220819134535.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210312s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3324/haematol.2012.069807 |2 doi | |
| 035 | |a (DE-627)1751222640 | ||
| 035 | |a (DE-599)KXP1751222640 | ||
| 035 | |a (OCoLC)1341398249 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Casanovas, Guillem |e VerfasserIn |0 (DE-588)1019496428 |0 (DE-627)690921365 |0 (DE-576)358225841 |4 aut | |
| 245 | 1 | 4 | |a The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice |c Guillem Casanovas, Maja Vujić Spasić, Carla Casu, Stefano Rivella, Jens Strelau, Klaus Unsicker, and Martina U. Muckenthaler |
| 264 | 1 | |c 2013 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.03.2021 | ||
| 520 | |a In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages. It has been suggested that hepcidin suppression is controlled by growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β superfamily of cytokines that is secreted from developing erythroblasts. In this study, we analyzed iron-related parameters in mice deficient for GDF15 under steady-state conditions and in response to increased erythropoietic activity induced by blood loss. We demonstrate that GDF15 suppresses the hepatic mRNA expression of some BMP/TGFβ target genes but not of hepcidin, and show that GDF15 is not required to balance iron homeostasis in response to blood loss. | ||
| 700 | 1 | |a Spasić Vujić, Maja |e VerfasserIn |0 (DE-588)1047514028 |0 (DE-627)778498131 |0 (DE-576)18546596X |4 aut | |
| 700 | 1 | |a Casu, Carla |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rivella, Stefano |e VerfasserIn |0 (DE-588)116004385X |0 (DE-627)1023138247 |0 (DE-576)505460041 |4 aut | |
| 700 | 1 | |a Strelau, Jens |e VerfasserIn |0 (DE-588)1055073841 |0 (DE-627)792630645 |0 (DE-576)411144456 |4 aut | |
| 700 | 1 | |a Unsicker, Klaus |d 1942- |e VerfasserIn |0 (DE-588)106365614 |0 (DE-627)503360635 |0 (DE-576)289555515 |4 aut | |
| 700 | 1 | |a Muckenthaler, Martina |e VerfasserIn |0 (DE-588)1046124595 |0 (DE-627)775766496 |0 (DE-576)173146813 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Haematologica, the hematology journal |d Pavia : Ferrata Storti Foundation, 2005 |g 98(2013), 3, Seite 444-447 |h Online-Ressource |w (DE-627)48524375X |w (DE-600)2186022-1 |w (DE-576)414771095 |x 1592-8721 |7 nnas |a The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice |
| 773 | 1 | 8 | |g volume:98 |g year:2013 |g number:3 |g pages:444-447 |g extent:4 |a The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice |
| 856 | 4 | 0 | |u https://doi.org/10.3324/haematol.2012.069807 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://haematologica.org/article/view/6599 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210312 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1046124595 |a Muckenthaler, Martina |m 1046124595:Muckenthaler, Martina |d 910000 |d 910500 |d 50000 |e 910000PM1046124595 |e 910500PM1046124595 |e 50000PM1046124595 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 7 |y j | ||
| 998 | |g 106365614 |a Unsicker, Klaus |m 106365614:Unsicker, Klaus |d 50000 |e 50000PU106365614 |k 0/50000/ |p 6 | ||
| 998 | |g 1055073841 |a Strelau, Jens |m 1055073841:Strelau, Jens |d 700000 |d 712000 |d 50000 |d 53100 |e 700000PS1055073841 |e 712000PS1055073841 |e 50000PS1055073841 |e 53100PS1055073841 |k 0/700000/ |k 1/700000/712000/ |k 0/50000/ |k 1/50000/53100/ |p 5 | ||
| 998 | |g 1047514028 |a Spasić Vujić, Maja |m 1047514028:Spasić Vujić, Maja |d 910000 |d 910500 |e 910000PS1047514028 |e 910500PS1047514028 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 998 | |g 1019496428 |a Casanovas, Guillem |m 1019496428:Casanovas, Guillem |p 1 |x j | ||
| 999 | |a KXP-PPN1751222640 |e 3885944235 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Casanovas, Guillem","family":"Casanovas","role":"aut","given":"Guillem"},{"family":"Spasić Vujić","display":"Spasić Vujić, Maja","role":"aut","given":"Maja"},{"given":"Carla","role":"aut","family":"Casu","display":"Casu, Carla"},{"display":"Rivella, Stefano","family":"Rivella","given":"Stefano","role":"aut"},{"given":"Jens","role":"aut","family":"Strelau","display":"Strelau, Jens"},{"role":"aut","given":"Klaus","family":"Unsicker","display":"Unsicker, Klaus"},{"family":"Muckenthaler","display":"Muckenthaler, Martina","role":"aut","given":"Martina"}],"note":["Gesehen am 12.03.2021"],"title":[{"title_sort":"murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice","title":"The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice"}],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"4 S."}],"name":{"displayForm":["Guillem Casanovas, Maja Vujić Spasić, Carla Casu, Stefano Rivella, Jens Strelau, Klaus Unsicker, and Martina U. Muckenthaler"]},"recId":"1751222640","id":{"eki":["1751222640"],"doi":["10.3324/haematol.2012.069807"]},"relHost":[{"part":{"extent":"4","volume":"98","year":"2013","text":"98(2013), 3, Seite 444-447","pages":"444-447","issue":"3"},"note":["Gesehen am 27.09.2018"],"origin":[{"dateIssuedDisp":"2005-2013","publisherPlace":"Pavia","dateIssuedKey":"2005","publisher":"Ferrata Storti Foundation"}],"title":[{"title":"Haematologica, the hematology journal","title_sort":"Haematologica, the hematology journal","subtitle":"official organ of the European Hematology Association"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"disp":"The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized miceHaematologica, the hematology journal","id":{"issn":["1592-8721"],"eki":["48524375X"],"zdb":["2186022-1"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"48524375X","pubHistory":["90.2005 - 98.2013"]}]} | ||
| SRT | |a CASANOVASGMURINEGROW2013 | ||