Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier
The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we impleme...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 June 1999
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| In: |
Magnetic resonance imaging
Year: 1999, Volume: 17, Issue: 1, Pages: 21-27 |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/S0730-725X(98)00149-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0730-725X(98)00149-0 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X98001490 
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| Author Notes: | Sabine Heiland, Thomas Benner, Jürgen Debus, Katrin Rempp, Wolfgang Reith, and Klaus Sartor |
MARC
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| 245 | 1 | 0 | |a Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood- brain-barrier |c Sabine Heiland, Thomas Benner, Jürgen Debus, Katrin Rempp, Wolfgang Reith, and Klaus Sartor |
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| 520 | |a The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we implemented a dual-echo RF-spoiled FLASH sequence (TE = 6/23.6 ms). We developed a postprocessing routine that allowed to calculate a signal-time course representing only the change in T2∗ and another one representing only the change in T1. Using this method, we examined 7 patients with various brain lesions showing evidence of BBB disruption. In the signal-time-curves obtained from the early echo we found a distinct signal drop due to the T2∗ effect. These effects could be eliminated by the correction algorithm yielding a 67% higher signal increase. Correction of the signal-time curve of the late echo yielded a more pronounced maximum signal drop and a decrease in postcontrast signal intensity. We found that without this correction the relative regional cerebral blood volume and the first moment of the concentration-time curve were underestimated by 72% and 22%, respectively. The dual echo-sequence combined with the postprocessing algorithm separates T1 and T2∗ effects and thus allows to assess cerebral hemodynamics and contrast agent kinetics simultaneously. This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors. | ||
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