Cover Image

First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases

Objectives: - To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS. - Background: - ALPPS is a two-stage hepatectomy variant that increases resection rates and R0 r...

Full description

Saved in:
Bibliographic Details
Main Authors: Petrowsky, Henrik (Author) , Linecker, Michael (Author) , Raptis, Dimitri Aristotle (Author) , Kuemmerli, Christoph (Author) , Fritsch, Ralph (Author) , Kirimker, Onur E. (Author) , Balci, Deniz (Author) , Ratti, Francesca (Author) , Aldrighetti, Luca (Author) , Voskanyan, Sergey (Author) , Tomassini, Federico (Author) , Troisi, Roberto I. (Author) , Bednarsch, Jan (Author) , Lurje, Georg (Author) , Fard-Aghaie, Mohammad-Hossein (Author) , Reese, Tim (Author) , Oldhafer, Karl Jürgen (Author) , Ghamarnejad, Omid (Author) , Mehrabi, Arianeb (Author) , Abraham, Mauro E. Tun (Author) , Truant, Stéphanie (Author) , Pruvot, Francois-René (Author) , Hoti, Emir (Author) , Kambakamba, Patryk (Author) , Capobianco, Ivan (Author) , Nadalin, Silvio (Author) , Fernandes, Eduardo S. M. (Author) , Kron, Philipp (Author) , Lodge, Peter (Author) , Olthof, Pim B. (Author) , Gulik, Thomas Mathijs van (Author) , Castro-Benitez, Carlos (Author) , Adam, René (Author) , Machado, Marcel Autran (Author) , Teutsch, Martin (Author) , Li, Jun (Author) , Scherer, Marcus N. (Author) , Schlitt, Hans Jürgen (Author) , Ardiles, Victoria (Author) , Santibañes, Eduardo <deœ (Author) , Brusadin, Roberto (Author) , Lopez-Lopez, Victor (Author) , Robles-Campos, Ricardo (Author) , Malagó, Massimo (Author) , Hernandez-Alejandro, Roberto (Author) , Clavien, Pierre-Alain (Author)
Format: Article (Journal)
Language:English
Published: August 21, 2020
In: Annals of surgery
Year: 2020, Volume: 272, Issue: 5, Pages: 793-800
ISSN:1528-1140
DOI:10.1097/SLA.0000000000004330
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/SLA.0000000000004330
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/Fulltext/2020/11000/First_Long_term_Oncologic_Results_of_the_ALPPS.19.aspx
Get full text
Author Notes:Henrik Petrowsky, MD, Michael Linecker, MD, PhD, Dimitri A. Raptis, MD, PhD, Christoph Kuemmerli, MD, Ralph Fritsch, MD, Onur E. Kirimker, MD, Deniz Balci, MD, Francesca Ratti, MD, Luca Aldrighetti, MD, Sergey Voskanyan, MD, Federico Tomassini, MD, Roberto I. Troisi, MD, Jan Bednarsch, MD, Georg Lurje, MD, Mohammad-Hossein Fard-Aghaie, MD, Tim Reese, MD, Karl J. Oldhafer, MD, Omid Ghamarnejad, MD, Arianeb Mehrabi, MD, Mauro E. Tun Abraham, MD, Stephanie Truant, MD, Francois-Rene ́Pruvot, MD, Emir Hoti, MD, Patryk Kambakamba, MD, Ivan Capobianco, MD, Silvio Nadalin, MD, Eduardo S.M. Fernandes, MD, MSc, Philipp Kron, MD, Peter Lodge, MD, Pim B. Olthof, MD, PhD, Thomas van Gulik, MD, PhD, Carlos Castro-Benitez, MD, PhD, Rene Adam, MD, Marcel Autran Machado, MD, Martin Teutsch, MD, Jun Li, MD, Marcus N. Scherer, MD, Hans J. Schlitt, MD, Victoria Ardiles, MD, Eduardo de Santibanes, MD, PhD, Roberto Brusadin, MD, Victor Lopez-Lopez, MD, Ricardo Robles-Campos, MD, Massimo Malago, MD, Roberto Hernandez-Alejandro, MD, and Pierre-Alain Clavien, MD, PhD

MARC

LEADER 00000caa a2200000 c 4500
001 1751420213
003 DE-627
005 20240412193315.0
007 cr uuu---uuuuu
008 210316s2020 xx |||||o 00| ||eng c
024 7 |a 10.1097/SLA.0000000000004330  |2 doi 
035 |a (DE-627)1751420213 
035 |a (DE-599)KXP1751420213 
035 |a (OCoLC)1341398887 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Petrowsky, Henrik  |d 1967-  |e VerfasserIn  |0 (DE-588)120147815  |0 (DE-627)696424223  |0 (DE-576)292063318  |4 aut 
245 1 0 |a First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases  |c Henrik Petrowsky, MD, Michael Linecker, MD, PhD, Dimitri A. Raptis, MD, PhD, Christoph Kuemmerli, MD, Ralph Fritsch, MD, Onur E. Kirimker, MD, Deniz Balci, MD, Francesca Ratti, MD, Luca Aldrighetti, MD, Sergey Voskanyan, MD, Federico Tomassini, MD, Roberto I. Troisi, MD, Jan Bednarsch, MD, Georg Lurje, MD, Mohammad-Hossein Fard-Aghaie, MD, Tim Reese, MD, Karl J. Oldhafer, MD, Omid Ghamarnejad, MD, Arianeb Mehrabi, MD, Mauro E. Tun Abraham, MD, Stephanie Truant, MD, Francois-Rene ́Pruvot, MD, Emir Hoti, MD, Patryk Kambakamba, MD, Ivan Capobianco, MD, Silvio Nadalin, MD, Eduardo S.M. Fernandes, MD, MSc, Philipp Kron, MD, Peter Lodge, MD, Pim B. Olthof, MD, PhD, Thomas van Gulik, MD, PhD, Carlos Castro-Benitez, MD, PhD, Rene Adam, MD, Marcel Autran Machado, MD, Martin Teutsch, MD, Jun Li, MD, Marcus N. Scherer, MD, Hans J. Schlitt, MD, Victoria Ardiles, MD, Eduardo de Santibanes, MD, PhD, Roberto Brusadin, MD, Victor Lopez-Lopez, MD, Ricardo Robles-Campos, MD, Massimo Malago, MD, Roberto Hernandez-Alejandro, MD, and Pierre-Alain Clavien, MD, PhD 
264 1 |c August 21, 2020 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 16.03.2021 
520 |a Objectives: - To analyze long-term oncological outcome along with prognostic risk factors in a large cohort of patients with colorectal liver metastases (CRLM) undergoing ALPPS. - Background: - ALPPS is a two-stage hepatectomy variant that increases resection rates and R0 resection rates in patients with primarily unresectable CRLM as evidenced in a recent randomized controlled trial. Long-term oncologic results, however, are lacking. - Methods: - Cases in- and outside the International ALPPS Registry were collected and completed by direct contacts to ALPPS centers to secure a comprehensive cohort. Overall, cancer-specific (CSS), and recurrence-free (RFS) survivals were analyzed along with independent risk factors using Cox-regression analysis. - Results: - The cohort included 510 patients from 22 ALPPS centers over a 10-year period. Ninety-day mortality was 4.9% and median overall survival, CSS, and RFS were 39, 42, and 15 months, respectively. The median follow-up time was 38 months (95% confidence interval 32-43 months). Multivariate analysis identified tumor-characteristics (primary T4, right colon), biological features (K/N-RAS status), and response to chemotherapy (Response Evaluation Criteria in Solid Tumors) as independent predictors of CSS. Traditional factors such as size of metastases, uni versus bilobar involvement, and liver-first approach were not predictive. When hepatic recurrences after ALPPS was amenable to surgical/ablative treatment, median CSS was significantly superior compared to chemotherapy alone (56 vs 30 months, P < 0.001). - Conclusions: - This large cohort provides the first evidence that patients with primarily unresectable CRLM treated by ALPPS have not only low perioperative mortality, but achieve appealing long-term oncologic outcome especially those with favorable tumor biology and good response to chemotherapy. 
700 1 |a Linecker, Michael  |d 1984-  |e VerfasserIn  |0 (DE-588)1179281888  |0 (DE-627)1066787689  |0 (DE-576)518173844  |4 aut 
700 1 |a Raptis, Dimitri Aristotle  |d 1978-  |e VerfasserIn  |0 (DE-588)1116548615  |0 (DE-627)870518356  |0 (DE-576)478490003  |4 aut 
700 1 |a Kuemmerli, Christoph  |e VerfasserIn  |4 aut 
700 1 |a Fritsch, Ralph  |d 1973-  |e VerfasserIn  |0 (DE-588)123776651  |0 (DE-627)70642350X  |0 (DE-576)293873801  |4 aut 
700 1 |a Kirimker, Onur E.  |e VerfasserIn  |4 aut 
700 1 |a Balci, Deniz  |e VerfasserIn  |4 aut 
700 1 |a Ratti, Francesca  |e VerfasserIn  |4 aut 
700 1 |a Aldrighetti, Luca  |e VerfasserIn  |4 aut 
700 1 |a Voskanyan, Sergey  |e VerfasserIn  |4 aut 
700 1 |a Tomassini, Federico  |e VerfasserIn  |4 aut 
700 1 |a Troisi, Roberto I.  |e VerfasserIn  |4 aut 
700 1 |a Bednarsch, Jan  |d 1989-  |e VerfasserIn  |0 (DE-588)1119749174  |0 (DE-627)872840212  |0 (DE-576)479961530  |4 aut 
700 1 |a Lurje, Georg  |d 1979-  |e VerfasserIn  |0 (DE-588)136689949  |0 (DE-627)694581410  |0 (DE-576)301211744  |4 aut 
700 1 |a Fard-Aghaie, Mohammad-Hossein  |e VerfasserIn  |4 aut 
700 1 |a Reese, Tim  |d 1986-  |e VerfasserIn  |0 (DE-588)1175398993  |0 (DE-627)1046331337  |0 (DE-576)516167693  |4 aut 
700 1 |a Oldhafer, Karl Jürgen  |d 1960-  |e VerfasserIn  |0 (DE-588)115580638  |0 (DE-627)691426678  |0 (DE-576)28996055X  |4 aut 
700 1 |a Ghamarnejad, Omid  |e VerfasserIn  |0 (DE-588)1163283258  |0 (DE-627)102748879X  |0 (DE-576)507869648  |4 aut 
700 1 |a Mehrabi, Arianeb  |d 1967-  |e VerfasserIn  |0 (DE-588)137664583  |0 (DE-627)594829763  |0 (DE-576)304831263  |4 aut 
700 1 |a Abraham, Mauro E. Tun  |e VerfasserIn  |4 aut 
700 1 |a Truant, Stéphanie  |e VerfasserIn  |4 aut 
700 1 |a Pruvot, Francois-René  |e VerfasserIn  |4 aut 
700 1 |a Hoti, Emir  |e VerfasserIn  |4 aut 
700 1 |a Kambakamba, Patryk  |d 1982-  |e VerfasserIn  |0 (DE-588)1116527553  |0 (DE-627)871205610  |0 (DE-576)478469381  |4 aut 
700 1 |a Capobianco, Ivan  |e VerfasserIn  |0 (DE-588)1227620659  |0 (DE-627)1748604910  |4 aut 
700 1 |a Nadalin, Silvio  |e VerfasserIn  |0 (DE-588)1016002343  |0 (DE-627)671218166  |0 (DE-576)351395431  |4 aut 
700 1 |a Fernandes, Eduardo S. M.  |e VerfasserIn  |4 aut 
700 1 |a Kron, Philipp  |e VerfasserIn  |4 aut 
700 1 |a Lodge, Peter  |e VerfasserIn  |4 aut 
700 1 |a Olthof, Pim B.  |e VerfasserIn  |4 aut 
700 1 |a Gulik, Thomas Mathijs van  |e VerfasserIn  |0 (DE-588)1047243709  |0 (DE-627)777897970  |0 (DE-576)400578824  |4 aut 
700 1 |a Castro-Benitez, Carlos  |e VerfasserIn  |4 aut 
700 1 |a Adam, René  |e VerfasserIn  |0 (DE-588)133875040  |0 (DE-627)557865581  |0 (DE-576)300163819  |4 aut 
700 1 |a Machado, Marcel Autran  |e VerfasserIn  |4 aut 
700 1 |a Teutsch, Martin  |e VerfasserIn  |4 aut 
700 1 |a Li, Jun  |e VerfasserIn  |4 aut 
700 1 |a Scherer, Marcus N.  |e VerfasserIn  |4 aut 
700 1 |a Schlitt, Hans Jürgen  |d 1961-  |e VerfasserIn  |0 (DE-588)111528836  |0 (DE-627)516471864  |0 (DE-576)289705207  |4 aut 
700 1 |a Ardiles, Victoria  |e VerfasserIn  |4 aut 
700 1 |a Santibañes, Eduardo <deœ  |d 1951-  |e VerfasserIn  |0 (DE-588)1225316111  |0 (DE-627)1744902100  |4 aut 
700 1 |a Brusadin, Roberto  |e VerfasserIn  |4 aut 
700 1 |a Lopez-Lopez, Victor  |e VerfasserIn  |4 aut 
700 1 |a Robles-Campos, Ricardo  |e VerfasserIn  |4 aut 
700 1 |a Malagó, Massimo  |e VerfasserIn  |0 (DE-588)173616364  |0 (DE-627)698526058  |0 (DE-576)134459512  |4 aut 
700 1 |a Hernandez-Alejandro, Roberto  |e VerfasserIn  |4 aut 
700 1 |a Clavien, Pierre-Alain  |e VerfasserIn  |0 (DE-588)133764850  |0 (DE-627)672424045  |0 (DE-576)353101176  |4 aut 
773 0 8 |i Enthalten in  |t Annals of surgery  |d [Erscheinungsort nicht ermittelbar] : Lippincott Williams & Wilkins, 1885  |g 272(2020), 5, Seite 793-800  |h Online-Ressource  |w (DE-627)313115222  |w (DE-600)2002200-1  |w (DE-576)090881796  |x 1528-1140  |7 nnas  |a First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases 
773 1 8 |g volume:272  |g year:2020  |g number:5  |g pages:793-800  |g extent:8  |a First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases 
856 4 0 |u https://doi.org/10.1097/SLA.0000000000004330  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://journals.lww.com/annalsofsurgery/Fulltext/2020/11000/First_Long_term_Oncologic_Results_of_the_ALPPS.19.aspx  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210316 
993 |a Article 
994 |a 2020 
998 |g 137664583  |a Mehrabi, Arianeb  |m 137664583:Mehrabi, Arianeb  |d 910000  |d 910200  |d 50000  |e 910000PM137664583  |e 910200PM137664583  |e 50000PM137664583  |k 0/910000/  |k 1/910000/910200/  |k 0/50000/  |p 19 
998 |g 1163283258  |a Ghamarnejad, Omid  |m 1163283258:Ghamarnejad, Omid  |d 50000  |e 50000PG1163283258  |k 0/50000/  |p 18 
999 |a KXP-PPN1751420213  |e 3889137725 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 16.03.2021"],"relHost":[{"id":{"eki":["313115222"],"zdb":["2002200-1"],"issn":["1528-1140"]},"origin":[{"publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedKey":"1885","dateIssuedDisp":"1885-","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; [Erscheinungsort nicht ermittelbar]"}],"part":{"text":"272(2020), 5, Seite 793-800","extent":"8","volume":"272","pages":"793-800","issue":"5","year":"2020"},"recId":"313115222","disp":"First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastasesAnnals of surgery","title":[{"subtitle":"a monthly review of surgical science and practice","title":"Annals of surgery","title_sort":"Annals of surgery"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 26.09.18"],"pubHistory":["1.1885 -"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"8 S."}],"person":[{"display":"Petrowsky, Henrik","role":"aut","given":"Henrik","family":"Petrowsky"},{"display":"Linecker, Michael","given":"Michael","role":"aut","family":"Linecker"},{"display":"Raptis, Dimitri Aristotle","family":"Raptis","role":"aut","given":"Dimitri Aristotle"},{"given":"Christoph","role":"aut","family":"Kuemmerli","display":"Kuemmerli, Christoph"},{"display":"Fritsch, Ralph","role":"aut","given":"Ralph","family":"Fritsch"},{"display":"Kirimker, Onur E.","role":"aut","given":"Onur E.","family":"Kirimker"},{"display":"Balci, Deniz","family":"Balci","role":"aut","given":"Deniz"},{"family":"Ratti","role":"aut","given":"Francesca","display":"Ratti, Francesca"},{"family":"Aldrighetti","role":"aut","given":"Luca","display":"Aldrighetti, Luca"},{"role":"aut","given":"Sergey","family":"Voskanyan","display":"Voskanyan, Sergey"},{"display":"Tomassini, Federico","family":"Tomassini","role":"aut","given":"Federico"},{"role":"aut","given":"Roberto I.","family":"Troisi","display":"Troisi, Roberto I."},{"display":"Bednarsch, Jan","role":"aut","given":"Jan","family":"Bednarsch"},{"display":"Lurje, Georg","role":"aut","given":"Georg","family":"Lurje"},{"display":"Fard-Aghaie, Mohammad-Hossein","family":"Fard-Aghaie","given":"Mohammad-Hossein","role":"aut"},{"display":"Reese, Tim","given":"Tim","role":"aut","family":"Reese"},{"family":"Oldhafer","given":"Karl Jürgen","role":"aut","display":"Oldhafer, Karl Jürgen"},{"display":"Ghamarnejad, Omid","family":"Ghamarnejad","given":"Omid","role":"aut"},{"given":"Arianeb","role":"aut","family":"Mehrabi","display":"Mehrabi, Arianeb"},{"role":"aut","given":"Mauro E. Tun","family":"Abraham","display":"Abraham, Mauro E. Tun"},{"role":"aut","given":"Stéphanie","family":"Truant","display":"Truant, Stéphanie"},{"display":"Pruvot, Francois-René","family":"Pruvot","given":"Francois-René","role":"aut"},{"family":"Hoti","role":"aut","given":"Emir","display":"Hoti, Emir"},{"display":"Kambakamba, Patryk","given":"Patryk","role":"aut","family":"Kambakamba"},{"role":"aut","given":"Ivan","family":"Capobianco","display":"Capobianco, Ivan"},{"display":"Nadalin, Silvio","family":"Nadalin","role":"aut","given":"Silvio"},{"display":"Fernandes, Eduardo S. M.","role":"aut","given":"Eduardo S. M.","family":"Fernandes"},{"display":"Kron, Philipp","role":"aut","given":"Philipp","family":"Kron"},{"family":"Lodge","given":"Peter","role":"aut","display":"Lodge, Peter"},{"role":"aut","given":"Pim B.","family":"Olthof","display":"Olthof, Pim B."},{"display":"Gulik, Thomas Mathijs van","family":"Gulik","given":"Thomas Mathijs van","role":"aut"},{"role":"aut","given":"Carlos","family":"Castro-Benitez","display":"Castro-Benitez, Carlos"},{"display":"Adam, René","family":"Adam","given":"René","role":"aut"},{"display":"Machado, Marcel Autran","family":"Machado","given":"Marcel Autran","role":"aut"},{"role":"aut","given":"Martin","family":"Teutsch","display":"Teutsch, Martin"},{"given":"Jun","role":"aut","family":"Li","display":"Li, Jun"},{"display":"Scherer, Marcus N.","given":"Marcus N.","role":"aut","family":"Scherer"},{"display":"Schlitt, Hans Jürgen","role":"aut","given":"Hans Jürgen","family":"Schlitt"},{"display":"Ardiles, Victoria","family":"Ardiles","given":"Victoria","role":"aut"},{"display":"Santibañes, Eduardo <deœ","role":"aut","given":"Eduardo <deœ","family":"Santibañes"},{"display":"Brusadin, Roberto","role":"aut","given":"Roberto","family":"Brusadin"},{"display":"Lopez-Lopez, Victor","family":"Lopez-Lopez","role":"aut","given":"Victor"},{"display":"Robles-Campos, Ricardo","given":"Ricardo","role":"aut","family":"Robles-Campos"},{"display":"Malagó, Massimo","given":"Massimo","role":"aut","family":"Malagó"},{"display":"Hernandez-Alejandro, Roberto","given":"Roberto","role":"aut","family":"Hernandez-Alejandro"},{"display":"Clavien, Pierre-Alain","family":"Clavien","role":"aut","given":"Pierre-Alain"}],"title":[{"title":"First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases","title_sort":"First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases"}],"name":{"displayForm":["Henrik Petrowsky, MD, Michael Linecker, MD, PhD, Dimitri A. Raptis, MD, PhD, Christoph Kuemmerli, MD, Ralph Fritsch, MD, Onur E. Kirimker, MD, Deniz Balci, MD, Francesca Ratti, MD, Luca Aldrighetti, MD, Sergey Voskanyan, MD, Federico Tomassini, MD, Roberto I. Troisi, MD, Jan Bednarsch, MD, Georg Lurje, MD, Mohammad-Hossein Fard-Aghaie, MD, Tim Reese, MD, Karl J. Oldhafer, MD, Omid Ghamarnejad, MD, Arianeb Mehrabi, MD, Mauro E. Tun Abraham, MD, Stephanie Truant, MD, Francois-Rene ́Pruvot, MD, Emir Hoti, MD, Patryk Kambakamba, MD, Ivan Capobianco, MD, Silvio Nadalin, MD, Eduardo S.M. Fernandes, MD, MSc, Philipp Kron, MD, Peter Lodge, MD, Pim B. Olthof, MD, PhD, Thomas van Gulik, MD, PhD, Carlos Castro-Benitez, MD, PhD, Rene Adam, MD, Marcel Autran Machado, MD, Martin Teutsch, MD, Jun Li, MD, Marcus N. Scherer, MD, Hans J. Schlitt, MD, Victoria Ardiles, MD, Eduardo de Santibanes, MD, PhD, Roberto Brusadin, MD, Victor Lopez-Lopez, MD, Ricardo Robles-Campos, MD, Massimo Malago, MD, Roberto Hernandez-Alejandro, MD, and Pierre-Alain Clavien, MD, PhD"]},"recId":"1751420213","id":{"doi":["10.1097/SLA.0000000000004330"],"eki":["1751420213"]},"origin":[{"dateIssuedDisp":"August 21, 2020","dateIssuedKey":"2020"}]} 
SRT |a PETROWSKYHFIRSTLONGT2120 

Similar Items