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Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva

With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine...

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Main Authors: Kim, Ti-Sun (Author) , Bürklin, Thomas (Author) , Schacher, Beate (Author) , Ratka‐Krüger, Petra (Author) , Schaecken, Matthijs T. (Author) , Renggli, Heinz H. (Author) , Fiehn, Walter (Author) , Eickholz, Peter (Author)
Format: Article (Journal)
Language:English
Published: 01 November 2002
In: Journal of periodontology
Year: 2002, Volume: 73, Issue: 11, Pages: 1285-1291
ISSN:1943-3670
DOI:10.1902/jop.2002.73.11.1285
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1902/jop.2002.73.11.1285
Verlag, lizenzpflichtig, Volltext: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2002.73.11.1285
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Author Notes:Ti-Sun Kim, Thomas Bürklin, Beate Schacher, Petra Ratka‐Krüger, Matthijs T. Schaecken, Heinz H. Renggli, Walter Fiehn, and Peter Eickholz
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Summary:With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine gel for local application. Pharmacokinetics of doxycycline (DOXY) were analyzed in GCF, saliva, and serum.
Item Description:Gesehen am 16.03.2021
Physical Description:Online Resource
ISSN:1943-3670
DOI:10.1902/jop.2002.73.11.1285

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