Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva
With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 November 2002
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| In: |
Journal of periodontology
Year: 2002, Volume: 73, Issue: 11, Pages: 1285-1291 |
| ISSN: | 1943-3670 |
| DOI: | 10.1902/jop.2002.73.11.1285 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1902/jop.2002.73.11.1285 Verlag, lizenzpflichtig, Volltext: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2002.73.11.1285 |
| Author Notes: | Ti-Sun Kim, Thomas Bürklin, Beate Schacher, Petra Ratka‐Krüger, Matthijs T. Schaecken, Heinz H. Renggli, Walter Fiehn, and Peter Eickholz |
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| 520 | |a With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine gel for local application. Pharmacokinetics of doxycycline (DOXY) were analyzed in GCF, saliva, and serum. | ||
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