Cover Image

Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva

With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine...

Full description

Saved in:
Bibliographic Details
Main Authors: Kim, Ti-Sun (Author) , Bürklin, Thomas (Author) , Schacher, Beate (Author) , Ratka‐Krüger, Petra (Author) , Schaecken, Matthijs T. (Author) , Renggli, Heinz H. (Author) , Fiehn, Walter (Author) , Eickholz, Peter (Author)
Format: Article (Journal)
Language:English
Published: 01 November 2002
In: Journal of periodontology
Year: 2002, Volume: 73, Issue: 11, Pages: 1285-1291
ISSN:1943-3670
DOI:10.1902/jop.2002.73.11.1285
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1902/jop.2002.73.11.1285
Verlag, lizenzpflichtig, Volltext: https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2002.73.11.1285
Get full text
Author Notes:Ti-Sun Kim, Thomas Bürklin, Beate Schacher, Petra Ratka‐Krüger, Matthijs T. Schaecken, Heinz H. Renggli, Walter Fiehn, and Peter Eickholz

MARC

LEADER 00000caa a2200000 c 4500
001 1751424936
003 DE-627
005 20230427005953.0
007 cr uuu---uuuuu
008 210316s2002 xx |||||o 00| ||eng c
024 7 |a 10.1902/jop.2002.73.11.1285  |2 doi 
035 |a (DE-627)1751424936 
035 |a (DE-599)KXP1751424936 
035 |a (OCoLC)1341398910 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Kim, Ti-Sun  |e VerfasserIn  |0 (DE-588)107028842X  |0 (DE-627)82440596X  |0 (DE-576)430000936  |4 aut 
245 1 0 |a Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva  |c Ti-Sun Kim, Thomas Bürklin, Beate Schacher, Petra Ratka‐Krüger, Matthijs T. Schaecken, Heinz H. Renggli, Walter Fiehn, and Peter Eickholz 
264 1 |c 01 November 2002 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 16.03.2021 
520 |a With the help of so-called controlled release delivery systems, the half-life period of locally administered antibiotics in gingival crevicular fluid (GCF) can be extended significantly. The aim of this study was to characterize the delivery profile of a new one-component 14% doxycycline free amine gel for local application. Pharmacokinetics of doxycycline (DOXY) were analyzed in GCF, saliva, and serum. 
650 4 |a Biodegradation 
650 4 |a controlled clinical trials 
650 4 |a doxycycline/therapeutic use 
650 4 |a drug delivery systems. 
700 1 |a Bürklin, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Schacher, Beate  |e VerfasserIn  |4 aut 
700 1 |a Ratka‐Krüger, Petra  |e VerfasserIn  |4 aut 
700 1 |a Schaecken, Matthijs T.  |e VerfasserIn  |4 aut 
700 1 |a Renggli, Heinz H.  |e VerfasserIn  |4 aut 
700 1 |a Fiehn, Walter  |e VerfasserIn  |0 (DE-588)111783705X  |0 (DE-627)871696606  |0 (DE-576)479343918  |4 aut 
700 1 |a Eickholz, Peter  |d 1963-  |e VerfasserIn  |0 (DE-588)17206063X  |0 (DE-627)69696533X  |0 (DE-576)13293485X  |4 aut 
773 0 8 |i Enthalten in  |t Journal of periodontology  |d Hoboken, NJ : Wiley, 1931  |g 73(2002), 11, Seite 1285-1291  |h Online-Ressource  |w (DE-627)325792062  |w (DE-600)2040047-0  |w (DE-576)098841467  |x 1943-3670  |7 nnas  |a Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva 
773 1 8 |g volume:73  |g year:2002  |g number:11  |g pages:1285-1291  |g extent:7  |a Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva 
856 4 0 |u https://doi.org/10.1902/jop.2002.73.11.1285  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2002.73.11.1285  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210316 
993 |a Article 
994 |a 2002 
998 |g 17206063X  |a Eickholz, Peter  |m 17206063X:Eickholz, Peter  |d 910000  |d 910800  |e 910000PE17206063X  |e 910800PE17206063X  |k 0/910000/  |k 1/910000/910800/  |p 8  |y j 
998 |g 111783705X  |a Fiehn, Walter  |m 111783705X:Fiehn, Walter  |d 910000  |d 910100  |e 910000PF111783705X  |e 910100PF111783705X  |k 0/910000/  |k 1/910000/910100/  |p 7 
998 |g 107028842X  |a Kim, Ti-Sun  |m 107028842X:Kim, Ti-Sun  |d 50000  |e 50000PK107028842X  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1751424936  |e 3889147682 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"7 S."}],"relHost":[{"note":["Gesehen am 05.06.20"],"pubHistory":["Nachgewiesen 2.1931 -"],"name":{"displayForm":["American Academy of Periodontology"]},"corporate":[{"role":"isb","display":"American Academy of Periodontology"}],"recId":"325792062","disp":"Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and salivaJournal of periodontology","language":["eng"],"part":{"issue":"11","year":"2002","pages":"1285-1291","text":"73(2002), 11, Seite 1285-1291","extent":"7","volume":"73"},"id":{"zdb":["2040047-0"],"issn":["1943-3670"],"doi":["10.1002/(ISSN)1943-3670"],"eki":["325792062"]},"title":[{"title_sort":"Journal of periodontology","title":"Journal of periodontology"}],"origin":[{"dateIssuedKey":"1931","publisherPlace":"Hoboken, NJ ; Chicago, Ill.","publisher":"Wiley ; American Academy of Periodontology","dateIssuedDisp":"1931-"}],"titleAlt":[{"title":"Journal of periodontology online"},{"title":"Journal of periodontology, periodontics"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1902/jop.2002.73.11.1285"],"eki":["1751424936"]},"title":[{"title_sort":"Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva","title":"Pharmacokinetic profile of a locally administered doxycycline gel in crevicular fluid, blood, and saliva"}],"origin":[{"dateIssuedKey":"2002","dateIssuedDisp":"01 November 2002"}],"recId":"1751424936","language":["eng"],"person":[{"display":"Kim, Ti-Sun","role":"aut","family":"Kim","given":"Ti-Sun"},{"display":"Bürklin, Thomas","family":"Bürklin","role":"aut","given":"Thomas"},{"given":"Beate","family":"Schacher","role":"aut","display":"Schacher, Beate"},{"given":"Petra","family":"Ratka‐Krüger","role":"aut","display":"Ratka‐Krüger, Petra"},{"role":"aut","family":"Schaecken","given":"Matthijs T.","display":"Schaecken, Matthijs T."},{"display":"Renggli, Heinz H.","given":"Heinz H.","family":"Renggli","role":"aut"},{"display":"Fiehn, Walter","role":"aut","family":"Fiehn","given":"Walter"},{"family":"Eickholz","role":"aut","given":"Peter","display":"Eickholz, Peter"}],"note":["Gesehen am 16.03.2021"],"name":{"displayForm":["Ti-Sun Kim, Thomas Bürklin, Beate Schacher, Petra Ratka‐Krüger, Matthijs T. Schaecken, Heinz H. Renggli, Walter Fiehn, and Peter Eickholz"]}} 
SRT |a KIMTISUNBUPHARMACOKI0120 

Similar Items