rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Rapid response of parkinsonian tremor to STN-DBS changes
    sub title: direct modulation of oscillatory basal ganglia activity?
  name:
    name part: Blahak, Christian
    name part: 1974-
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Bäzner, Hansjörg
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Capelle, Hans-Holger
    name part: 1972-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Wöhrle, Johannes C.
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Weigel, Ralf
    name part: 1965-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Hennerici, Michael G.
    name part: 1948-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Krauss, Joachim K.
    name part: 1957-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 5
  abstract: Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proved to be effective for tremor and other cardinal symptoms in Parkinson's disease (PD), the precise mechanisms of action of DBS are still unclear. We analyzed the time course of resting tremor amplitude and frequency during discontinuation and subsequent reinitiation of STN-DBS in nine PD patients, using a computerized three-dimensional motion analysis combined with surface electromyography. Following discontinuation of STN-DBS, resting tremor amplitude rapidly increased, reaching maximum amplitude after 2 min (mean ± 95%CI: 34.3 ± 13.8 mm; P < 0.01), subsequently stabilizing at a medium level. Reinitiation of stimulation after 30 min resulted in rapid, nearly complete suppression of tremor activity within 1 min (1.4 ± 1.3 mm; P < 0.01) and, furthermore, increased tremor frequency within a few seconds in seven of nine patients. These findings support the hypothesis that STN-DBS acts by direct interference with the neurotransmission of basal ganglia networks involved in tremor. © 2009 Movement Disorder Society
  note: Christian Blahak, MD, Hansjörg Bäzner, MD, PhD, Hans-Holger Capelle, MD, Johannes C. Wöhrle, MD, PhD, Ralf Weigel, MD, PhD, Michael G. Hennerici, MD, PhD, and Joachim K. Krauss, MD, PhD
  note: Gesehen am 17.03.2021
  subject:
    topic: deep brain stimulation
  subject:
    topic: Parkinson's disease
  subject:
    topic: subthalamic nucleus
  subject:
    topic: tremor
  classification: 33
  related item:
    title info:
      title: Movement disorders
    name:
      name part: Rapid response of parkinsonian tremor to STN-DBS changes direct modulation of oscillatory basal ganglia activity?
    origin info:
      publisher: New York, NY : Wiley, 1986
    physical description:
      extent: Online-Ressource
    identifier: 1531-8257
    identifier: (DE-627)326179658
    identifier: (DE-600)2041249-6
    identifier: (DE-576)094427003
    part:
      text: 24(2009), 8, Seite 1221-1225
  related item:
    name:
      name part: Rapid response of parkinsonian tremor to STN-DBS changes direct modulation of oscillatory basal ganglia activity?
    part:
      text: volume:24
    part:
      text: year:2009
    part:
      text: number:8
    part:
      text: pages:1221-1225
    part:
      text: extent:5
  identifier: https://doi.org/10.1002/mds.22536
  record info:
    record content source: DE-627
    record creation date: 210317
    record change date: 20220819135855.0
    record identifier: 1751594483
    language of cataloging:
      language term: ger