Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy
Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant local low-dose gamma irradiation (LDI) causes normalization of aberrant vasculature and efficient recruitment of tu...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 24, 2013
|
| In: |
Cancer cell
Year: 2013, Jahrgang: 24, Heft: 5, Pages: 589-602 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccr.2013.09.014 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccr.2013.09.014 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610813004212 
|
| Verfasserangaben: | Felix Klug, Hridayesh Prakash, Peter E. Huber, Tobias Seibel, Noemi Bender, Niels Halama, Christina Pfirschke, Ralf Holger Voss, Carmen Timke, Ludmila Umansky, Kay Klapproth, Knut Schäkel, Natalio Garbi, Dirk Jäger, Jürgen Weitz, Hubertus Schmitz-Winnenthal, Günter J. Hämmerling, and Philipp Beckhove |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1751874796 | ||
| 003 | DE-627 | ||
| 005 | 20240412193317.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210319s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ccr.2013.09.014 |2 doi | |
| 035 | |a (DE-627)1751874796 | ||
| 035 | |a (DE-599)KXP1751874796 | ||
| 035 | |a (OCoLC)1341400564 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Klug, Felix |e VerfasserIn |0 (DE-588)102997022X |0 (DE-627)734546149 |0 (DE-576)377792810 |4 aut | |
| 245 | 1 | 0 | |a Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy |c Felix Klug, Hridayesh Prakash, Peter E. Huber, Tobias Seibel, Noemi Bender, Niels Halama, Christina Pfirschke, Ralf Holger Voss, Carmen Timke, Ludmila Umansky, Kay Klapproth, Knut Schäkel, Natalio Garbi, Dirk Jäger, Jürgen Weitz, Hubertus Schmitz-Winnenthal, Günter J. Hämmerling, and Philipp Beckhove |
| 246 | 3 | 0 | |a one |
| 246 | 3 | 3 | |a Low-dose irradiation programs macrophage differentiation to an iNOS plus/M1 phenotype that orchestrates effective T cell immunotherapy |
| 264 | 1 | |c October 24, 2013 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist das Pluszeichen hochgestellt | ||
| 500 | |a Gesehen am 08.06.2022 | ||
| 520 | |a Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant local low-dose gamma irradiation (LDI) causes normalization of aberrant vasculature and efficient recruitment of tumor-specific T cells in human pancreatic carcinomas and T-cell-mediated tumor rejection and prolonged survival in otherwise immune refractory spontaneous and xenotransplant mouse tumor models. LDI (local or pre-adoptive-transfer) programs the differentiation of iNOS+ M1 macrophages that orchestrate CTL recruitment into and killing within solid tumors through iNOS by inducing endothelial activation and the expression of TH1 chemokines and by suppressing the production of angiogenic, immunosuppressive, and tumor growth factors. | ||
| 700 | 1 | |a Prakash, Hridayesh |e VerfasserIn |0 (DE-588)1154890228 |0 (DE-627)1016230605 |0 (DE-576)501296360 |4 aut | |
| 700 | 1 | |a Huber, Peter E. |d 1965- |e VerfasserIn |0 (DE-588)1074678869 |0 (DE-627)832350109 |0 (DE-576)442767803 |4 aut | |
| 700 | 1 | |a Seibel, Tobias Julian |e VerfasserIn |0 (DE-588)142856657 |0 (DE-627)640547559 |0 (DE-576)333730747 |4 aut | |
| 700 | 1 | |a Bender, Noemi |e VerfasserIn |0 (DE-588)1123669538 |0 (DE-627)877343993 |0 (DE-576)481881093 |4 aut | |
| 700 | 1 | |a Halama, Niels |d 1977- |e VerfasserIn |0 (DE-588)13087325X |0 (DE-627)507228723 |0 (DE-576)251045706 |4 aut | |
| 700 | 1 | |a Pfirschke, Christina |d 1981- |e VerfasserIn |0 (DE-588)1024790312 |0 (DE-627)720551218 |0 (DE-576)356367037 |4 aut | |
| 700 | 1 | |a Voß, Ralf-Holger |d 1964- |e VerfasserIn |0 (DE-588)12083667X |0 (DE-627)70502542X |0 (DE-576)292409079 |4 aut | |
| 700 | 1 | |a Timke, Carmen |d 1976- |e VerfasserIn |0 (DE-588)1013171535 |0 (DE-627)704974991 |0 (DE-576)346651840 |4 aut | |
| 700 | 1 | |a Umansky, Ludmila |e VerfasserIn |0 (DE-588)1129482650 |0 (DE-627)88408812X |0 (DE-576)48643138X |4 aut | |
| 700 | 1 | |a Klapproth, Kay |d 1972- |e VerfasserIn |0 (DE-588)14102626X |0 (DE-627)62450431X |0 (DE-576)321678257 |4 aut | |
| 700 | 1 | |a Schäkel, Knut |e VerfasserIn |0 (DE-588)1032757418 |0 (DE-627)739272896 |0 (DE-576)251064476 |4 aut | |
| 700 | 1 | |a Garbi, Natalio |d 1967- |e VerfasserIn |0 (DE-588)1120739578 |0 (DE-627)873687493 |0 (DE-576)480510822 |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Weitz, Jürgen |e VerfasserIn |0 (DE-588)1022345974 |0 (DE-627)716954451 |0 (DE-576)171632176 |4 aut | |
| 700 | 1 | |a Schmitz-Winnenthal, Friedrich Hubertus |d 1970- |e VerfasserIn |0 (DE-588)123474892 |0 (DE-627)706312589 |0 (DE-576)293724377 |4 aut | |
| 700 | 1 | |a Hämmerling, Günter J. |e VerfasserIn |0 (DE-588)1178691926 |0 (DE-627)1049544218 |0 (DE-576)517861348 |4 aut | |
| 700 | 1 | |a Beckhove, Philipp |d 1969- |e VerfasserIn |0 (DE-588)121272842 |0 (DE-627)705350169 |0 (DE-576)292620748 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer cell |d Cambridge, Mass. : Cell Press, 2002 |g 24(2013), 5, Seite 589-602 |h Online-Ressource |w (DE-627)343970082 |w (DE-600)2074034-7 |w (DE-576)097935972 |x 1878-3686 |7 nnas |a Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy |
| 773 | 1 | 8 | |g volume:24 |g year:2013 |g number:5 |g pages:589-602 |g extent:14 |a Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ccr.2013.09.014 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1535610813004212 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210319 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 121272842 |a Beckhove, Philipp |m 121272842:Beckhove, Philipp |d 50000 |e 50000PB121272842 |k 0/50000/ |p 18 |y j | ||
| 998 | |g 1178691926 |a Hämmerling, Günter |m 1178691926:Hämmerling, Günter |p 17 | ||
| 998 | |g 123474892 |a Schmitz-Winnenthal, Friedrich Hubertus |m 123474892:Schmitz-Winnenthal, Friedrich Hubertus |d 50000 |e 50000PS123474892 |k 0/50000/ |p 16 | ||
| 998 | |g 1022345974 |a Weitz, Jürgen |m 1022345974:Weitz, Jürgen |p 15 | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 14 | ||
| 998 | |g 1120739578 |a Garbi, Natalio |m 1120739578:Garbi, Natalio |d 140000 |e 140000PG1120739578 |k 0/140000/ |p 13 | ||
| 998 | |g 1032757418 |a Schäkel, Knut |m 1032757418:Schäkel, Knut |d 910000 |d 911300 |e 910000PS1032757418 |e 911300PS1032757418 |k 0/910000/ |k 1/910000/911300/ | ||
| 998 | |g 14102626X |a Klapproth, Kay |m 14102626X:Klapproth, Kay |p 11 | ||
| 998 | |g 1129482650 |a Umansky, Ludmila |m 1129482650:Umansky, Ludmila |p 10 | ||
| 998 | |g 1013171535 |a Timke, Carmen |m 1013171535:Timke, Carmen |p 9 | ||
| 998 | |g 1024790312 |a Pfirschke, Christina |m 1024790312:Pfirschke, Christina |p 7 | ||
| 998 | |g 13087325X |a Halama, Niels |m 13087325X:Halama, Niels |d 910000 |d 910100 |e 910000PH13087325X |e 910100PH13087325X |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1123669538 |a Bender, Noemi |m 1123669538:Bender, Noemi |d 140000 |e 140000PB1123669538 |k 0/140000/ |p 5 | ||
| 998 | |g 1074678869 |a Huber, Peter E. |m 1074678869:Huber, Peter E. |d 50000 |e 50000PH1074678869 |k 0/50000/ |p 3 | ||
| 998 | |g 1154890228 |a Prakash, Hridayesh |m 1154890228:Prakash, Hridayesh |p 2 | ||
| 998 | |g 102997022X |a Klug, Felix |m 102997022X:Klug, Felix |p 1 |x j | ||
| 999 | |a KXP-PPN1751874796 |e 3891131542 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"titleAlt":[{"title":"Low-dose irradiation programs macrophage differentiation to an iNOS plus/M1 phenotype that orchestrates effective T cell immunotherapy"}],"relHost":[{"part":{"extent":"14","year":"2013","volume":"24","issue":"5","text":"24(2013), 5, Seite 589-602","pages":"589-602"},"title":[{"title":"Cancer cell","title_sort":"Cancer cell"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapyCancer cell","language":["eng"],"origin":[{"publisherPlace":"Cambridge, Mass. ; New York, NY","dateIssuedKey":"2002","dateIssuedDisp":"2002-","publisher":"Cell Press ; Elsevier"}],"note":["Gesehen am 28.02.11"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"343970082","id":{"zdb":["2074034-7"],"eki":["343970082"],"issn":["1878-3686"]},"pubHistory":["1.2002 -"]}],"title":[{"title":"Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy","title_sort":"Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy"}],"id":{"eki":["1751874796"],"doi":["10.1016/j.ccr.2013.09.014"]},"recId":"1751874796","name":{"displayForm":["Felix Klug, Hridayesh Prakash, Peter E. Huber, Tobias Seibel, Noemi Bender, Niels Halama, Christina Pfirschke, Ralf Holger Voss, Carmen Timke, Ludmila Umansky, Kay Klapproth, Knut Schäkel, Natalio Garbi, Dirk Jäger, Jürgen Weitz, Hubertus Schmitz-Winnenthal, Günter J. Hämmerling, and Philipp Beckhove"]},"person":[{"role":"aut","display":"Klug, Felix","family":"Klug","given":"Felix"},{"family":"Prakash","given":"Hridayesh","role":"aut","display":"Prakash, Hridayesh"},{"display":"Huber, Peter E.","role":"aut","given":"Peter E.","family":"Huber"},{"given":"Tobias Julian","family":"Seibel","display":"Seibel, Tobias Julian","role":"aut"},{"display":"Bender, Noemi","role":"aut","given":"Noemi","family":"Bender"},{"display":"Halama, Niels","role":"aut","family":"Halama","given":"Niels"},{"given":"Christina","family":"Pfirschke","display":"Pfirschke, Christina","role":"aut"},{"given":"Ralf-Holger","family":"Voß","display":"Voß, Ralf-Holger","role":"aut"},{"role":"aut","display":"Timke, Carmen","family":"Timke","given":"Carmen"},{"given":"Ludmila","family":"Umansky","role":"aut","display":"Umansky, Ludmila"},{"display":"Klapproth, Kay","role":"aut","family":"Klapproth","given":"Kay"},{"family":"Schäkel","given":"Knut","role":"aut","display":"Schäkel, Knut"},{"display":"Garbi, Natalio","role":"aut","family":"Garbi","given":"Natalio"},{"role":"aut","display":"Jäger, Dirk","given":"Dirk","family":"Jäger"},{"display":"Weitz, Jürgen","role":"aut","family":"Weitz","given":"Jürgen"},{"display":"Schmitz-Winnenthal, Friedrich Hubertus","role":"aut","family":"Schmitz-Winnenthal","given":"Friedrich Hubertus"},{"family":"Hämmerling","given":"Günter J.","role":"aut","display":"Hämmerling, Günter J."},{"family":"Beckhove","given":"Philipp","role":"aut","display":"Beckhove, Philipp"}],"physDesc":[{"extent":"14 S."}],"note":["Im Titel ist das Pluszeichen hochgestellt","Gesehen am 08.06.2022"],"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"October 24, 2013"}]} | ||
| SRT | |a KLUGFELIXPLOWDOSEIRR2420 | ||