Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy

Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant local low-dose gamma irradiation (LDI) causes normalization of aberrant vasculature and efficient recruitment of tu...

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Main Authors:	Klug, Felix (Author) , Prakash, Hridayesh (Author) , Huber, Peter E. (Author) , Seibel, Tobias Julian (Author) , Bender, Noemi (Author) , Halama, Niels (Author) , Pfirschke, Christina (Author) , Voß, Ralf-Holger (Author) , Timke, Carmen (Author) , Umansky, Ludmila (Author) , Klapproth, Kay (Author) , Schäkel, Knut (Author) , Garbi, Natalio (Author) , Jäger, Dirk (Author) , Weitz, Jürgen (Author) , Schmitz-Winnenthal, Friedrich Hubertus (Author) , Hämmerling, Günter J. (Author) , Beckhove, Philipp (Author)
Format:	Article (Journal)
Language:	English
Published:	October 24, 2013
In:	Cancer cell Year: 2013, Volume: 24, Issue: 5, Pages: 589-602
ISSN:	1878-3686
DOI:	10.1016/j.ccr.2013.09.014
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccr.2013.09.014 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610813004212
Author Notes:	Felix Klug, Hridayesh Prakash, Peter E. Huber, Tobias Seibel, Noemi Bender, Niels Halama, Christina Pfirschke, Ralf Holger Voss, Carmen Timke, Ludmila Umansky, Kay Klapproth, Knut Schäkel, Natalio Garbi, Dirk Jäger, Jürgen Weitz, Hubertus Schmitz-Winnenthal, Günter J. Hämmerling, and Philipp Beckhove