Cover Image

Pain-modulating effects of oxytocin in patients with chronic low back pain

The neuropeptide oxytocin (OT) has been shown to play a modulatory role in nociception. However, analgesic effects of OT in chronic pain conditions remain elusive and the neural underpinnings have not yet been investigated in humans. Here, we conducted an exploratory, randomized, placebo-controlled,...

Full description

Saved in:
Bibliographic Details
Main Authors: Boll, Sabrina (Author) , Ueltzhöffer, Kai (Author) , Roth, Corinna (Author) , Bertsch, Katja (Author) , Desch, Simon (Author) , Nees, Frauke (Author) , Grinevich, Valéry (Author) , Herpertz, Sabine (Author)
Format: Article (Journal)
Language:English
Published: 13 April 2020
In: Neuropharmacology
Year: 2020, Volume: 171, Pages: 1-10
ISSN:1873-7064
DOI:10.1016/j.neuropharm.2020.108105
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuropharm.2020.108105
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0028390820301738
Get full text
Author Notes:Sabrina Boll, Kai Ueltzhoeffer, Corinna Roth, Katja Bertsch, Simon Desch, Frauke Nees, Valery Grinevich, Sabine C. Herpertz

MARC

LEADER 00000caa a2200000 c 4500
001 1752021495
003 DE-627
005 20240413193228.0
007 cr uuu---uuuuu
008 210322s2020 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.neuropharm.2020.108105  |2 doi 
035 |a (DE-627)1752021495 
035 |a (DE-599)KXP1752021495 
035 |a (OCoLC)1341400808 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Boll, Sabrina  |e VerfasserIn  |0 (DE-588)1042784655  |0 (DE-627)769665829  |0 (DE-576)394220277  |4 aut 
245 1 0 |a Pain-modulating effects of oxytocin in patients with chronic low back pain  |c Sabrina Boll, Kai Ueltzhoeffer, Corinna Roth, Katja Bertsch, Simon Desch, Frauke Nees, Valery Grinevich, Sabine C. Herpertz 
264 1 |c 13 April 2020 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.03.2021 
520 |a The neuropeptide oxytocin (OT) has been shown to play a modulatory role in nociception. However, analgesic effects of OT in chronic pain conditions remain elusive and the neural underpinnings have not yet been investigated in humans. Here, we conducted an exploratory, randomized, placebo-controlled, cross-over study to examine effects of intranasal OT in male patients suffering from chronic low back pain (CBP) versus healthy controls (HC). N = 22 participants with CBP and 22 HCs were scanned using functional magnetic resonance imaging (fMRI) while they continuously rated either spontaneously occurring back pain or acute thermal pain stimuli applied to the lower back. During heat pain processing we found that OT versus PL attenuated pain intensity ratings and increased BOLD responses in the caudate nucleus of the striatum in CBP versus HCs. Spontaneously experienced pain in contrast to heat pain was associated with activation changes in the medial frontal cortex (MFC) and the anterior cingulate cortex (ACC) as reported in previous studies. However, we did not observe OT effects on spontaneously experienced pain in CBP patients. Overall, our preliminary data may suggest that the striatum is a key structure underlying the pain-modulating effects of OT in patients with chronic pain and adds to the growing evidence linking the neuropeptide to pain modulation in humans. Further studies on neuronal OT effects in larger samples of chronic back pain patients are needed to understand probable mechanisms of OT effects in chronic pain. This article is part of the special issue on Neuropeptides. 
650 4 |a Caudate 
650 4 |a Chronic low back pain 
650 4 |a fMRI 
650 4 |a Heat pain 
650 4 |a Oxytocin 
650 4 |a Striatum 
700 1 |a Ueltzhöffer, Kai  |d 1985-  |e VerfasserIn  |0 (DE-588)1116632047  |0 (DE-627)870587773  |0 (DE-576)478539207  |4 aut 
700 1 |a Roth, Corinna  |e VerfasserIn  |0 (DE-588)1116728370  |0 (DE-627)870653458  |0 (DE-576)47857908X  |4 aut 
700 1 |a Bertsch, Katja  |d 1981-  |e VerfasserIn  |0 (DE-588)141519568  |0 (DE-627)629442355  |0 (DE-576)324253478  |4 aut 
700 1 |a Desch, Simon  |d 1985-  |e VerfasserIn  |0 (DE-588)129127541X  |0 (DE-627)184716028X  |4 aut 
700 1 |a Nees, Frauke  |e VerfasserIn  |0 (DE-588)140286527  |0 (DE-627)703627244  |0 (DE-576)325389764  |4 aut 
700 1 |a Grinevich, Valéry  |e VerfasserIn  |0 (DE-588)1158696574  |0 (DE-627)1020774606  |0 (DE-576)504314289  |4 aut 
700 1 |a Herpertz, Sabine  |d 1960-  |e VerfasserIn  |0 (DE-588)132328526  |0 (DE-627)520581113  |0 (DE-576)182985261  |4 aut 
773 0 8 |i Enthalten in  |t Neuropharmacology  |d Amsterdam [u.a.] : Elsevier Science, 1970  |g 171(2020) vom: Juli, Artikel-ID 108105, Seite 1-10  |h Online-Ressource  |w (DE-627)30666125X  |w (DE-600)1500655-4  |w (DE-576)081986831  |x 1873-7064  |7 nnas  |a Pain-modulating effects of oxytocin in patients with chronic low back pain 
773 1 8 |g volume:171  |g year:2020  |g month:07  |g elocationid:108105  |g pages:1-10  |g extent:10  |a Pain-modulating effects of oxytocin in patients with chronic low back pain 
856 4 0 |u https://doi.org/10.1016/j.neuropharm.2020.108105  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0028390820301738  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210322 
993 |a Article 
994 |a 2020 
998 |g 132328526  |a Herpertz, Sabine  |m 132328526:Herpertz, Sabine  |d 910000  |d 910600  |e 910000PH132328526  |e 910600PH132328526  |k 0/910000/  |k 1/910000/910600/  |p 8  |y j 
998 |g 1158696574  |a Grinevich, Valéry  |m 1158696574:Grinevich, Valéry  |d 60000  |e 60000PG1158696574  |k 0/60000/  |p 7 
998 |g 140286527  |a Nees, Frauke  |m 140286527:Nees, Frauke  |p 6 
998 |g 129127541X  |a Desch, Simon  |m 129127541X:Desch, Simon  |d 60000  |e 60000PD129127541X  |k 0/60000/  |p 5 
998 |g 141519568  |a Bertsch, Katja  |m 141519568:Bertsch, Katja  |d 910000  |d 910600  |d 100000  |e 910000PB141519568  |e 910600PB141519568  |e 100000PB141519568  |k 0/910000/  |k 1/910000/910600/  |k 0/100000/  |p 4 
998 |g 1116728370  |a Roth, Corinna  |m 1116728370:Roth, Corinna  |d 910000  |d 910600  |e 910000PR1116728370  |e 910600PR1116728370  |k 0/910000/  |k 1/910000/910600/  |p 3 
998 |g 1116632047  |a Ueltzhöffer, Kai  |m 1116632047:Ueltzhöffer, Kai  |d 910000  |d 910600  |e 910000PU1116632047  |e 910600PU1116632047  |k 0/910000/  |k 1/910000/910600/  |p 2 
998 |g 1042784655  |a Boll, Sabrina  |m 1042784655:Boll, Sabrina  |p 1  |x j 
999 |a KXP-PPN1752021495  |e 389248709X 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"name":{"displayForm":["Sabrina Boll, Kai Ueltzhoeffer, Corinna Roth, Katja Bertsch, Simon Desch, Frauke Nees, Valery Grinevich, Sabine C. Herpertz"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"10 S."}],"id":{"eki":["1752021495"],"doi":["10.1016/j.neuropharm.2020.108105"]},"person":[{"role":"aut","given":"Sabrina","display":"Boll, Sabrina","family":"Boll"},{"display":"Ueltzhöffer, Kai","given":"Kai","role":"aut","family":"Ueltzhöffer"},{"family":"Roth","given":"Corinna","display":"Roth, Corinna","role":"aut"},{"family":"Bertsch","role":"aut","given":"Katja","display":"Bertsch, Katja"},{"family":"Desch","given":"Simon","display":"Desch, Simon","role":"aut"},{"family":"Nees","role":"aut","display":"Nees, Frauke","given":"Frauke"},{"given":"Valéry","display":"Grinevich, Valéry","role":"aut","family":"Grinevich"},{"family":"Herpertz","display":"Herpertz, Sabine","given":"Sabine","role":"aut"}],"title":[{"title_sort":"Pain-modulating effects of oxytocin in patients with chronic low back pain","title":"Pain-modulating effects of oxytocin in patients with chronic low back pain"}],"note":["Gesehen am 22.03.2021"],"origin":[{"dateIssuedDisp":"13 April 2020","dateIssuedKey":"2020"}],"relHost":[{"disp":"Pain-modulating effects of oxytocin in patients with chronic low back painNeuropharmacology","physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2020","pages":"1-10","text":"171(2020) vom: Juli, Artikel-ID 108105, Seite 1-10","volume":"171","extent":"10"},"title":[{"title_sort":"Neuropharmacology","title":"Neuropharmacology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"30666125X","pubHistory":["9.1970 -"],"note":["Gesehen am 20.02.20"],"origin":[{"dateIssuedKey":"1970","publisher":"Elsevier Science","dateIssuedDisp":"1970-","publisherPlace":"Amsterdam [u.a.]"}],"id":{"issn":["1873-7064"],"zdb":["1500655-4"],"eki":["30666125X"]},"language":["eng"]}],"recId":"1752021495"} 
SRT |a BOLLSABRINPAINMODULA1320 

Similar Items