Residual γH2AX foci predict local tumour control after radiotherapy
Purpose - Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo. - Materials & methods - GammaH2AX foci were quantified in perfused tumour areas 30min (initial γH2AX foci) and 24h (residua...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 July 2013
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| In: |
Radiotherapy and oncology
Year: 2013, Volume: 108, Issue: 3, Pages: 434-439 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2013.06.022 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2013.06.022 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814013003010 
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| Author Notes: | Ulrike Koch, Katharina Höhne, Cläre von Neubeck, Howard D. Thames, Ala Yaromina, Jochen Dahm-Daphi, Michael Baumann, Mechthild Krause |
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| 245 | 1 | 0 | |a Residual γH2AX foci predict local tumour control after radiotherapy |c Ulrike Koch, Katharina Höhne, Cläre von Neubeck, Howard D. Thames, Ala Yaromina, Jochen Dahm-Daphi, Michael Baumann, Mechthild Krause |
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| 520 | |a Purpose - Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo. - Materials & methods - GammaH2AX foci were quantified in perfused tumour areas 30min (initial γH2AX foci) and 24h (residual γH2AX foci) after exposure to a single dose of 4Gy. The initial and residual normalised γH2AX foci were correlated with TCD50 after single dose irradiation under clamped blood flow (SDclamp) or a fractionated irradiation setting under ambient blood flow (fx). - Results - A significant negative correlation between initial and residual normalised γH2AX foci and TCD50 SDclamp and TCD50 fx for 9 HNSCC tumour xenograft models in vivo was found. Residual normalised γH2AX foci showed higher intertumoural variability and their correlation with TCD50 was more robust. - Conclusions - For the first time a significant negative correlation between γH2AX foci and local tumour control after irradiation has been demonstrated. Our results underline the potential of residual γH2AX foci as a predictive biomarker for local tumour control after radiotherapy. | ||
| 650 | 4 | |a Biomarker | |
| 650 | 4 | |a DNA repair | |
| 650 | 4 | |a Local tumour control | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Tumour micromilieu | |
| 650 | 4 | |a γH2AX | |
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