Cover Image

Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue

Show other versions (1)

1378 - Objectives PET/CT with [68Ga]DOTA0-Phe1-Tyr3-octreotide (68Ga-DOTA-TOC) became a standard for somatostatin receptor imaging. We investigated the potential changes of normal tissue uptake in patients with neuroendocrine tumor undergoing peptide receptor radionuclide therapy (PRRT). - Methods S...

Full description

Saved in:
Bibliographic Details
Main Authors: Giesel, Frederik L. (Author) , Stefanova, Mesla (Author) , Afshar-Oromieh, Ali (Author) , Mier, Walter (Author) , Haberkorn, Uwe (Author) , Kratochwil, Clemens (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Journal of nuclear medicine
Year: 2013, Volume: 54
ISSN:2159-662X
Online Access:Verlag, lizenzpflichtig, Volltext: https://jnm.snmjournals.org/content/54/supplement_2/1378
Get full text
Author Notes:Frederik Giesel, Mesla Stefanova, Ali Afshar-Oromieh, Walter Mier, Uwe Haberkorn, Clemens Kratochwil

MARC

LEADER 00000caa a2200000 c 4500
001 1752072650
003 DE-627
005 20230427020310.0
007 cr uuu---uuuuu
008 210322s2013 xx |||||o 00| ||eng c
035 |a (DE-627)1752072650 
035 |a (DE-599)KXP1752072650 
035 |a (OCoLC)1341400913 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Giesel, Frederik L.  |d 1970-  |e VerfasserIn  |0 (DE-588)129031240  |0 (DE-627)387883878  |0 (DE-576)297457071  |4 aut 
245 1 0 |a Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue  |c Frederik Giesel, Mesla Stefanova, Ali Afshar-Oromieh, Walter Mier, Uwe Haberkorn, Clemens Kratochwil 
264 1 |c 2013 
300 |a ? 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.03.2021 
520 |a 1378 - Objectives PET/CT with [68Ga]DOTA0-Phe1-Tyr3-octreotide (68Ga-DOTA-TOC) became a standard for somatostatin receptor imaging. We investigated the potential changes of normal tissue uptake in patients with neuroendocrine tumor undergoing peptide receptor radionuclide therapy (PRRT). - Methods Sixteen patients underwent [68Ga]-DOTA-TOC-PET/CT prior and after 4-6 cycles of PRRT (mean administered activity: 13.8 GBq 90Y+ 9.6 177Lu). The maximum standardized uptake values (SUVmax) of pituitary, thyroid, spleen, liver parenchyma, pancreas, kidneys and adrenals were determined, respectively. - Results SUVmax values prior and after PRRT were in pituitary (5, 56±2,91/4,47 ±2,53), thyroid (2,05±1,11/2,49±2,47), spleen (24,95±14,20/20,06±8,53), liver (7,13±3,96/6,62±2,63), pancreas (6,96±1,99/6,83±2,00), kidneys (13,0±3,85/ 11,31±3,31) and adrenals (9,65±4,20/7,10 ±2,86). A comparison of pre- and post treatment values revealed no significant differences (p>0.05) in any of these organs. - Conclusions The uptake of [68Ga] DOTA-TOC in normal tissue is not significantly affected by PRRT. This is relevant with regards to therapeutic monitoring were tumor-to-non-tumor ratio seems to be the most robust biomarker. - Research Support The uptake of [68Ga]DOTA-TOC in physiological SSTR expressing organs such as pituary, thyroid and adrenal glands is not significantly affected by PRRT. Therefore, it seems that there is neither an acute nor chronic side effect for the physiological expression of SSTRs in endocrine organs at the upper limit of activity recommended for PRRT. 
700 1 |a Stefanova, Mesla  |e VerfasserIn  |4 aut 
700 1 |a Afshar-Oromieh, Ali  |d 1975-  |e VerfasserIn  |0 (DE-588)130260436  |0 (DE-627)496579711  |0 (DE-576)189580003  |4 aut 
700 1 |a Mier, Walter  |d 1966-  |e VerfasserIn  |0 (DE-588)12029026X  |0 (DE-627)69653567X  |0 (DE-576)292141599  |4 aut 
700 1 |a Haberkorn, Uwe  |d 1959-  |e VerfasserIn  |0 (DE-588)1022913905  |0 (DE-627)717331245  |0 (DE-576)366166352  |4 aut 
700 1 |a Kratochwil, Clemens  |d 1978-  |e VerfasserIn  |0 (DE-588)134026276  |0 (DE-627)559871686  |0 (DE-576)300262787  |4 aut 
773 0 8 |i Enthalten in  |t Journal of nuclear medicine  |d New York, NY : Soc., 1964  |g 54(2013), Supplement 2 vom: Mai, Artikel-ID 1378  |h Online-Ressource  |w (DE-627)325793603  |w (DE-600)2040222-3  |w (DE-576)09475277X  |x 2159-662X  |7 nnas  |a Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue 
773 1 8 |g volume:54  |g year:2013  |g month:05  |g supplement:Supplement 2  |g elocationid:1378  |g extent:?  |a Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue 
856 4 0 |u https://jnm.snmjournals.org/content/54/supplement_2/1378  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210322 
993 |a Article 
994 |a 2013 
998 |g 134026276  |a Kratochwil, Clemens  |m 134026276:Kratochwil, Clemens  |d 910000  |d 911400  |e 910000PK134026276  |e 911400PK134026276  |k 0/910000/  |k 1/910000/911400/  |p 6  |y j 
998 |g 1022913905  |a Haberkorn, Uwe  |m 1022913905:Haberkorn, Uwe  |d 910000  |d 911400  |e 910000PH1022913905  |e 911400PH1022913905  |k 0/910000/  |k 1/910000/911400/  |p 5 
998 |g 12029026X  |a Mier, Walter  |m 12029026X:Mier, Walter  |d 910000  |d 911400  |e 910000PM12029026X  |e 911400PM12029026X  |k 0/910000/  |k 1/910000/911400/  |p 4 
998 |g 130260436  |a Afshar-Oromieh, Ali  |m 130260436:Afshar-Oromieh, Ali  |d 50000  |e 50000PA130260436  |k 0/50000/  |p 3 
998 |g 129031240  |a Giesel, Frederik L.  |m 129031240:Giesel, Frederik L.  |d 910000  |d 911400  |e 910000PG129031240  |e 911400PG129031240  |k 0/910000/  |k 1/910000/911400/  |p 1  |x j 
999 |a KXP-PPN1752072650  |e 3892659060 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1752072650","name":{"displayForm":["Frederik Giesel, Mesla Stefanova, Ali Afshar-Oromieh, Walter Mier, Uwe Haberkorn, Clemens Kratochwil"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"2013"}],"id":{"eki":["1752072650"]},"language":["eng"],"physDesc":[{"extent":"? S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue","title":"Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissue"}],"person":[{"family":"Giesel","given":"Frederik L.","role":"aut","display":"Giesel, Frederik L."},{"role":"aut","given":"Mesla","family":"Stefanova","display":"Stefanova, Mesla"},{"family":"Afshar-Oromieh","given":"Ali","role":"aut","display":"Afshar-Oromieh, Ali"},{"family":"Mier","given":"Walter","role":"aut","display":"Mier, Walter"},{"family":"Haberkorn","given":"Uwe","role":"aut","display":"Haberkorn, Uwe"},{"display":"Kratochwil, Clemens","family":"Kratochwil","role":"aut","given":"Clemens"}],"relHost":[{"part":{"text":"54(2013), Supplement 2 vom: Mai, Artikel-ID 1378","extent":"?","volume":"54","year":"2013"},"pubHistory":["Nachgewiesen 5.1964 -"],"note":["Gesehen am 13.12.2021"],"titleAlt":[{"title":"JNM"}],"disp":"Impact of peptide receptor radionuclide therapy (PRRT) on the 68Ga-DOTATOC-PET/CT uptake in normal tissueJournal of nuclear medicine","name":{"displayForm":["Society of Nuclear Medicine"]},"recId":"325793603","id":{"zdb":["2040222-3"],"issn":["2159-662X","1535-5667"],"eki":["325793603"]},"origin":[{"publisher":"Soc.","dateIssuedKey":"1964","dateIssuedDisp":"1964-","publisherPlace":"New York, NY"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"corporate":[{"display":"Society of Nuclear Medicine","role":"isb"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Journal of nuclear medicine","subtitle":"JNM","title":"Journal of nuclear medicine"}]}],"note":["Gesehen am 22.03.2021"]} 
SRT |a GIESELFREDIMPACTOFPE2013 

Similar Items