A novel murine PKA-related protein kinase involved in neuronal differentiation
Members of the cAMP-dependent second-messenger pathway have been described as regulators of cellular growth and differentiation and were consequently implicated in a variety of embryogenic processes including brain development. Moreover, recent data suggest an indispensable role for cAMP-dependent p...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 March 2000
|
| In: |
Genomics
Year: 2000, Jahrgang: 64, Heft: 2, Pages: 187-194 |
| ISSN: | 1089-8646 |
| DOI: | 10.1006/geno.2000.6116 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1006/geno.2000.6116 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0888754300961160 
|
| Verfasserangaben: | Rüdiger J. Blaschke, A. Paula Monaghan, Dagmar Bock and Gudrun A. Rappold |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1752434706 | ||
| 003 | DE-627 | ||
| 005 | 20220819144907.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210325s2000 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1006/geno.2000.6116 |2 doi | |
| 035 | |a (DE-627)1752434706 | ||
| 035 | |a (DE-599)KXP1752434706 | ||
| 035 | |a (OCoLC)1341401400 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Blaschke, Rüdiger Jörg |e VerfasserIn |0 (DE-588)1076498256 |0 (DE-627)834993295 |0 (DE-576)256073422 |4 aut | |
| 245 | 1 | 2 | |a A novel murine PKA-related protein kinase involved in neuronal differentiation |c Rüdiger J. Blaschke, A. Paula Monaghan, Dagmar Bock and Gudrun A. Rappold |
| 264 | 1 | |c 1 March 2000 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.03.2021 | ||
| 520 | |a Members of the cAMP-dependent second-messenger pathway have been described as regulators of cellular growth and differentiation and were consequently implicated in a variety of embryogenic processes including brain development. Moreover, recent data suggest an indispensable role for cAMP-dependent protein kinases (PKAs) in neuronal differentiation and synaptic plasticity. Using a degenerate primer-based approach, we have identified a novel murine gene closely related to the human cAMP-dependent protein kinase PRKX on Xp22.3. This gene (Pkare) was mapped to the region near the centromere of the murine X chromosome and is expressed in a variety of adult organs including kidney, liver, spleen, testis, ovary, lung, heart, and brain. Antisense in situ hybridization on staged mouse embryos revealed a highly distinctive expression pattern during neuronal development, with elevated Pkare expression observed only in differentiating neurons within the first ganglion, the dorsal root ganglia, and the mantle layer of the telencephalon. Based on the close relationship with the catalytic PKA subunits and its distinct expression in differentiating neuronal cells, Pkare might represent a novel component of the cAMP-regulated pathways involved in brain development and function. | ||
| 700 | 1 | |a Monaghan, A. Paula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bock, Dagmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rappold, Gudrun |d 1954- |e VerfasserIn |0 (DE-588)102028319X |0 (DE-627)691169594 |0 (DE-576)359985947 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Genomics |d San Diego, Calif. : Academic Press, 1987 |g 64(2000), 2, Seite 187-194 |h Online-Ressource |w (DE-627)266881815 |w (DE-600)1468023-3 |w (DE-576)078707269 |x 1089-8646 |7 nnas |a A novel murine PKA-related protein kinase involved in neuronal differentiation |
| 773 | 1 | 8 | |g volume:64 |g year:2000 |g number:2 |g pages:187-194 |g extent:8 |a A novel murine PKA-related protein kinase involved in neuronal differentiation |
| 856 | 4 | 0 | |u https://doi.org/10.1006/geno.2000.6116 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0888754300961160 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210325 | ||
| 993 | |a Article | ||
| 994 | |a 2000 | ||
| 998 | |g 102028319X |a Rappold, Gudrun |m 102028319X:Rappold, Gudrun |d 910000 |d 911500 |e 910000PR102028319X |e 911500PR102028319X |k 0/910000/ |k 1/910000/911500/ |p 4 |y j | ||
| 998 | |g 1076498256 |a Blaschke, Rüdiger Jörg |m 1076498256:Blaschke, Rüdiger Jörg |d 910000 |d 911500 |e 910000PB1076498256 |e 911500PB1076498256 |k 0/910000/ |k 1/910000/911500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1752434706 |e 389435593X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Rüdiger J. Blaschke, A. Paula Monaghan, Dagmar Bock and Gudrun A. Rappold"]},"origin":[{"dateIssuedDisp":"1 March 2000","dateIssuedKey":"2000"}],"id":{"eki":["1752434706"],"doi":["10.1006/geno.2000.6116"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"San Diego, Calif.","dateIssuedKey":"1987","publisher":"Academic Press","dateIssuedDisp":"1987-"}],"id":{"eki":["266881815"],"zdb":["1468023-3"],"issn":["1089-8646"]},"pubHistory":["1.1987 -"],"part":{"volume":"64","text":"64(2000), 2, Seite 187-194","extent":"8","year":"2000","issue":"2","pages":"187-194"},"note":["Gesehen am 08.06.2022","Fortsetzung der Druck-Ausgabe"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"A novel murine PKA-related protein kinase involved in neuronal differentiationGenomics","language":["eng"],"recId":"266881815","title":[{"subtitle":"an international journal for analysis of the human and other genomes","title":"Genomics","title_sort":"Genomics"}]}],"person":[{"family":"Blaschke","given":"Rüdiger Jörg","roleDisplay":"VerfasserIn","display":"Blaschke, Rüdiger Jörg","role":"aut"},{"role":"aut","display":"Monaghan, A. Paula","roleDisplay":"VerfasserIn","given":"A. Paula","family":"Monaghan"},{"role":"aut","display":"Bock, Dagmar","roleDisplay":"VerfasserIn","given":"Dagmar","family":"Bock"},{"display":"Rappold, Gudrun","roleDisplay":"VerfasserIn","role":"aut","family":"Rappold","given":"Gudrun"}],"title":[{"title_sort":"novel murine PKA-related protein kinase involved in neuronal differentiation","title":"A novel murine PKA-related protein kinase involved in neuronal differentiation"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 25.03.2021"],"recId":"1752434706","language":["eng"]} | ||
| SRT | |a BLASCHKERUNOVELMURIN1200 | ||