GABAB receptor antibodies in paraneoplastic cerebellar ataxia
Autoantibodies to the gamma-aminobutyric acid-B (GABAB) receptor were recently described in patients with limbic encephalitis presenting with early or prominent seizures. We report on a 64-year-old man with malignant melanoma who during adjuvant therapy with interferon (IFN)-alpha developed cerebell...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 January 2013
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| In: |
Journal of neuroimmunology
Year: 2013, Jahrgang: 256, Heft: 1/2, Pages: 94-96 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2012.12.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2012.12.006 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572812003396 
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| Verfasserangaben: | Sven Jarius, Florian Steinmeyer, Astrid Knobel, Kaspar Streitberger, Benjamin Hotter, Sigrun Horn, Heike Heuer, Stephan J. Schreiber, Tabea Wilhelm, Uwe Trefzer, Brigitte Wildemann, Klemens Ruprecht |
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| 520 | |a Autoantibodies to the gamma-aminobutyric acid-B (GABAB) receptor were recently described in patients with limbic encephalitis presenting with early or prominent seizures. We report on a 64-year-old man with malignant melanoma who during adjuvant therapy with interferon (IFN)-alpha developed cerebellar ataxia. Indirect immunofluorescence on brain tissue sections revealed high-titer (1:20,000) IgG1 serum autoantibodies to the cerebellar molecular and granular layer, which were confirmed to be directed against GABAB receptor in a cell-based assay. This case highlights cerebellar ataxia in the absence of seizures as a clinical manifestation of GABAB receptor autoimmunity and extends the spectrum of tumors underlying this condition to malignant melanoma. IFN-alpha therapy may have contributed to the development of autoimmunity in this patient. | ||
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| 650 | 4 | |a Indirect immunofluorescence | |
| 650 | 4 | |a Interferon alpha | |
| 650 | 4 | |a Malignant melanoma | |
| 650 | 4 | |a Paraneoplastic neurological syndrome | |
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