Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL
We have isolated a novel gene, ASMTL (acetylserotonin methytransferase-likej, in the pseudoautosomal region (PAR1) on the human sex chromosomes. ASMTL represents a unique fusion product of two different full-length genes of different evolutionary origin and function. One part is homologous to the ba...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 October 1998
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| In: |
Human molecular genetics
Year: 1998, Jahrgang: 7, Heft: 11, Pages: 1771-1778 |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/7.11.1771 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/hmg/7.11.1771
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| Verfasserangaben: | K. Ried, E. Rao, K. Schiebel, G.A. Rappold |
| Zusammenfassung: | We have isolated a novel gene, ASMTL (acetylserotonin methytransferase-likej, in the pseudoautosomal region (PAR1) on the human sex chromosomes. ASMTL represents a unique fusion product of two different full-length genes of different evolutionary origin and function. One part is homologous to the bacterial maf/orfE genes. The other part shows significant homology to the entire open reading frame of the previously described pseudoautosomal gene ASMT , encoding the enzyme catalysing the last step in the synthesis of melatonin. We have also detected the identity of one exon (1A) of ASMTto exon 3 in yet another pseudoautosomal gene, XE7 . The data presented suggest that exon duplication and exon shuffling as well as gene fusion may represent common characteristics in the pseudoautosomal region. |
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| Beschreibung: | Gesehen am 29.03.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/7.11.1771 |