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Formation of a polymer surface with a gradient of pore size using a microfluidic chip

Here we demonstrate the generation of polymer monolithic surfaces possessing a gradient of pore and polymer globule sizes from ∼0.1 to ∼0.5 μm defined by the composition of two polymerization mixtures injected into a microfluidic chip. To generate the gradient, we used a PDMS microfluidic chip with...

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Hauptverfasser: Kreppenhofer, Kristina (VerfasserIn) , Li, Junsheng (VerfasserIn) , Segura, Rodrigo (VerfasserIn) , Popp, Ludmilla (VerfasserIn) , Rossi, Massimiliano (VerfasserIn) , Tzvetkova, Pavleta (VerfasserIn) , Luy, Burkhard (VerfasserIn) , Kähler, Christian J. (VerfasserIn) , Guber, Andreas E. (VerfasserIn) , Levkin, Pavel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 21, 2013
In: Langmuir
Year: 2013, Jahrgang: 29, Heft: 11, Pages: 3797-3804
ISSN:1520-5827
DOI:10.1021/la304997a
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/la304997a
Volltext
Verfasserangaben:Kristina Kreppenhofer, Junsheng Li, Rodrigo Segura, Ludmilla Popp, Massimiliano Rossi, Pavleta Tzvetkova, Burkhard Luy, Christian J. Kähler, Andreas E. Guber, and Pavel A. Levkin
Beschreibung
Zusammenfassung:Here we demonstrate the generation of polymer monolithic surfaces possessing a gradient of pore and polymer globule sizes from ∼0.1 to ∼0.5 μm defined by the composition of two polymerization mixtures injected into a microfluidic chip. To generate the gradient, we used a PDMS microfluidic chip with a cascade micromixer with a subsequent reaction chamber for the formation of a continuous gradient film. The micromixer has zigzag channels of 400 × 680 μm2 cross section and six cascades. The chip was used with a reversible bonding connection, realized by curing agent coating. After polymerization in the microfluidic chip the reversible bond was opened, resulting in a 450 μm thick polymer film possessing the pore size gradient. The gradient formation in the microfluidic reaction chamber was studied using microscopic laser-induced fluorescence (μLIF) and different model fluids. Formation of linear gradients was shown using the fluids of the same density by both diffusive mixing at flow rates of 0.001 mL/min and in a convective mixing regime at flow rates of 20 mL/min. By using different density fluids, formation of a two-dimensional wedge-like gradient controlled by the density difference and orientation of the microfluidic chip was observed.
Beschreibung:Gesehen am 31.03.2021
Beschreibung:Online Resource
ISSN:1520-5827
DOI:10.1021/la304997a

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