A human pseudoautosomal gene, ADP/ATP translocase, escapes X-inactivation whereas a homologue on Xq is subject to X-inactivation
We report the cloning of a highly conserved pseudoautosomal gene on the human sex chromosomes. A cDNA clone was selected by crosshybridization with a microdissected clone from the chromosomal subregion Xp22.3. It encodes a previously characterized member of the ADP/ATP translocase family and plays a...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 January 1993
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| In: |
Nature genetics
Year: 1993, Volume: 3, Issue: 1, Pages: 82-87 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng0193-82 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ng0193-82 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ng0193-82 
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| Author Notes: | Katrin Schiebel, Birgit Weiss, Doris Wöhrle & Gudrun Rappold |
| Summary: | We report the cloning of a highly conserved pseudoautosomal gene on the human sex chromosomes. A cDNA clone was selected by crosshybridization with a microdissected clone from the chromosomal subregion Xp22.3. It encodes a previously characterized member of the ADP/ATP translocase family and plays a fundamental role in cellular energy metabolism. This gene, ANT3, is located approximately 1,300 kilobases from the telomere, proximal to the pseudoautosomal gene CSF2RA, and escapes X-inactivation. Interestingly, a homologue of ANT3, ANT2, maps to Xq and is subject to X-inactivation. These genes provide the first evidence of two closely related X-chromosomal genes, which show striking differences in their X-inactivation behaviour. |
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| Item Description: | Gesehen am 30.03.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng0193-82 |