Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion
The detailed molecular mechanisms following activation of apoptosis in ischemia-reperfusion injury are unknown. This study using different transgenic mouse models provided first evidence that apoptosis in myocardial ischemia-reperfusion injury is rather linked to the mitochondrial pathway than to de...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 February 2013
|
| In: |
Cardiovascular pathology
Year: 2013, Volume: 22, Issue: 4, Pages: 280-286 |
| ISSN: | 1879-1336 |
| DOI: | 10.1016/j.carpath.2013.01.004 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.carpath.2013.01.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1054880713000070 
|
| Author Notes: | Arnt V. Kristen, Katrin Ackermann, Sebastian Buss, Lorenz Lehmann, Philipp A. Schnabel, Armin Haunstetter, Hugo A. Katus, Stefan E. Hardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1752777077 | ||
| 003 | DE-627 | ||
| 005 | 20220819151139.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210330s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.carpath.2013.01.004 |2 doi | |
| 035 | |a (DE-627)1752777077 | ||
| 035 | |a (DE-599)KXP1752777077 | ||
| 035 | |a (OCoLC)1341401954 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kristen, Arnt |d 1974- |e VerfasserIn |0 (DE-588)123480965 |0 (DE-627)706314530 |0 (DE-576)293726876 |4 aut | |
| 245 | 1 | 0 | |a Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion |c Arnt V. Kristen, Katrin Ackermann, Sebastian Buss, Lorenz Lehmann, Philipp A. Schnabel, Armin Haunstetter, Hugo A. Katus, Stefan E. Hardt |
| 264 | 1 | |c 11 February 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 31.03.2021 | ||
| 520 | |a The detailed molecular mechanisms following activation of apoptosis in ischemia-reperfusion injury are unknown. This study using different transgenic mouse models provided first evidence that apoptosis in myocardial ischemia-reperfusion injury is rather linked to the mitochondrial pathway than to death receptor pathway. - Introduction - There is a wealth of evidence for activation of apoptosis in ischemia-reperfusion injury. However, the understanding of detailed molecular mechanism is lacking. - Methods - The extent of myocardial infarction after ligation of the left anterior descending artery in mice carrying different transgenes for inhibition of either the intrinsic or the extrinsic or a combination of both apoptotic cascades was evaluated. The extent of myocardial damage was assessed by echocardiographic determination of left ventricular (LV) ejection fraction, LV hemodynamics, troponin T, and histology. The rate of apoptosis was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 staining. - Results - Highest perioperative rate of death was observed in the dominant-negative form of a truncated Fas-associated death domain (FADD-DN) group. Infarction size by 2,3,5-triphenyltetrazolium chloride (TTC) staining was smaller in the Bcl-2, but not in the other groups as compared to wild-type mice. This was accompanied by lower troponin T values in Bcl-2 transgenic mice as compared to the all other groups. Troponin T correlated well with macroscopic extent of myocardial infarction by TTC staining. A lower decline of LV ejection fraction was seen in the Bcl-2 as compared to wild-type or FADD-DN mice. A smaller number of TUNEL- and caspase-3-positive myocyte nuclei were observed in the Bcl-2 and FADD-DN group as compared to wild-type mice. - Conclusions - We provide first evidence for protective effects on the myocardium in a transgenic mouse model of myocardial ischemia-reperfusion due to inhibition of the Bcl-2, but not the FADD pathway despite that reduced apoptotic cells were observed in both groups as compared to wild-type mice. | ||
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Bcl-2 | |
| 650 | 4 | |a Death receptors | |
| 650 | 4 | |a FADD | |
| 650 | 4 | |a Ischemia-reperfusion | |
| 650 | 4 | |a Mitochondrion | |
| 700 | 1 | |a Ackermann, Katrin |d 1973- |e VerfasserIn |0 (DE-588)1038724554 |0 (DE-627)766371492 |0 (DE-576)392760932 |4 aut | |
| 700 | 1 | |a Buß, Sebastian Johannes |d 1977- |e VerfasserIn |0 (DE-588)131490451 |0 (DE-627)509814050 |0 (DE-576)298541963 |4 aut | |
| 700 | 1 | |a Lehmann, Lorenz |d 1980- |e VerfasserIn |0 (DE-588)131855212 |0 (DE-627)515807184 |0 (DE-576)298796104 |4 aut | |
| 700 | 1 | |a Schnabel, Philipp Albert |d 1953-2021 |e VerfasserIn |0 (DE-588)102254960X |0 (DE-627)717000087 |0 (DE-576)16982750X |4 aut | |
| 700 | 1 | |a Haunstetter, Armin |e VerfasserIn |0 (DE-588)1052546978 |0 (DE-627)788604570 |0 (DE-576)408318139 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Hardt, Stefan |e VerfasserIn |0 (DE-588)1028380585 |0 (DE-627)730637611 |0 (DE-576)375919309 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiovascular pathology |d Amsterdam [u.a.] : Elsevier Science, 1992 |g 22(2013), 4 vom: Juli/Aug., Seite 280-286 |h Online-Ressource |w (DE-627)306654385 |w (DE-600)1499916-X |w (DE-576)081984677 |x 1879-1336 |7 nnas |a Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion |
| 773 | 1 | 8 | |g volume:22 |g year:2013 |g number:4 |g month:07/08 |g pages:280-286 |g extent:7 |a Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.carpath.2013.01.004 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1054880713000070 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210330 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1028380585 |a Hardt, Stefan |m 1028380585:Hardt, Stefan |d 50000 |e 50000PH1028380585 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1052546978 |a Haunstetter, Armin |m 1052546978:Haunstetter, Armin |p 6 | ||
| 998 | |g 102254960X |a Schnabel, Philipp Albert |m 102254960X:Schnabel, Philipp Albert |d 910000 |d 912000 |e 910000PS102254960X |e 912000PS102254960X |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 131855212 |a Lehmann, Lorenz |m 131855212:Lehmann, Lorenz |d 910000 |d 910100 |e 910000PL131855212 |e 910100PL131855212 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 131490451 |a Buß, Sebastian Johannes |m 131490451:Buß, Sebastian Johannes |d 910000 |d 910100 |e 910000PB131490451 |e 910100PB131490451 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1038724554 |a Ackermann, Katrin |m 1038724554:Ackermann, Katrin |d 50000 |e 50000PA1038724554 |k 0/50000/ |p 2 | ||
| 998 | |g 123480965 |a Kristen, Arnt |m 123480965:Kristen, Arnt |d 910000 |d 910100 |d 50000 |e 910000PK123480965 |e 910100PK123480965 |e 50000PK123480965 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1752777077 |e 3897968053 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 31.03.2021"],"recId":"1752777077","id":{"doi":["10.1016/j.carpath.2013.01.004"],"eki":["1752777077"]},"title":[{"title_sort":"Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion","title":"Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion"}],"relHost":[{"pubHistory":["1.1992 -"],"recId":"306654385","physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2013","extent":"7","pages":"280-286","text":"22(2013), 4 vom: Juli/Aug., Seite 280-286","volume":"22","issue":"4"},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1992","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1992-"}],"language":["eng"],"title":[{"title":"Cardiovascular pathology","title_sort":"Cardiovascular pathology"}],"id":{"issn":["1879-1336"],"eki":["306654385"],"zdb":["1499916-X"]},"disp":"Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusionCardiovascular pathology","note":["Gesehen am 22.01.2020"]}],"person":[{"roleDisplay":"VerfasserIn","family":"Kristen","given":"Arnt","display":"Kristen, Arnt","role":"aut"},{"family":"Ackermann","roleDisplay":"VerfasserIn","display":"Ackermann, Katrin","role":"aut","given":"Katrin"},{"display":"Buß, Sebastian Johannes","role":"aut","given":"Sebastian Johannes","family":"Buß","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Lehmann","given":"Lorenz","role":"aut","display":"Lehmann, Lorenz"},{"family":"Schnabel","roleDisplay":"VerfasserIn","given":"Philipp Albert","display":"Schnabel, Philipp Albert","role":"aut"},{"given":"Armin","role":"aut","display":"Haunstetter, Armin","roleDisplay":"VerfasserIn","family":"Haunstetter"},{"roleDisplay":"VerfasserIn","family":"Katus","given":"Hugo","display":"Katus, Hugo","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Hardt","role":"aut","display":"Hardt, Stefan","given":"Stefan"}],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Arnt V. Kristen, Katrin Ackermann, Sebastian Buss, Lorenz Lehmann, Philipp A. Schnabel, Armin Haunstetter, Hugo A. Katus, Stefan E. Hardt"]},"origin":[{"dateIssuedDisp":"11 February 2013","dateIssuedKey":"2013"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"]} | ||
| SRT | |a KRISTENARNINHIBITION1120 | ||