NF-κB is activated and promotes cell death in focal cerebral ischemia
The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1999
|
| In: |
Nature medicine
Year: 1999, Volume: 5, Issue: 5, Pages: 554-559 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/8432 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/8432 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm0599_554 |
| Author Notes: | Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth & Markus Schwaninger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1753064309 | ||
| 003 | DE-627 | ||
| 005 | 20230426165431.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210401s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/8432 |2 doi | |
| 035 | |a (DE-627)1753064309 | ||
| 035 | |a (DE-599)KXP1753064309 | ||
| 035 | |a (OCoLC)1341402118 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schneider, Armin |d 1965- |e VerfasserIn |0 (DE-588)120356775 |0 (DE-627)696597012 |0 (DE-576)189089946 |4 aut | |
| 245 | 1 | 0 | |a NF-κB is activated and promotes cell death in focal cerebral ischemia |c Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth & Markus Schwaninger |
| 246 | 3 | 3 | |a NF-kappaB is activated and promotes cell death in focal cerebral ischemia |
| 246 | 3 | 3 | |a NF-kappa B is activated and promotes cell death in focal cerebral ischemia |
| 264 | 1 | |c 1999 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.04.2021 | ||
| 520 | |a The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter transgene, nuclear translocation of NF-κB in neurons and enhanced DNA binding of NF-κB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-κB in focal ischemia. NF-κB may provide a new pharmacological target in neurologic disease. | ||
| 700 | 1 | |a Martín-Villalba, Ana |d 1971- |e VerfasserIn |0 (DE-588)12035988X |0 (DE-627)696601338 |0 (DE-576)292177690 |4 aut | |
| 700 | 1 | |a Weih, Falk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vogel, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wirth, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwaninger, Markus |e VerfasserIn |0 (DE-588)1028374909 |0 (DE-627)730623939 |0 (DE-576)375910174 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature medicine |d [New York, NY] : Springer Nature, 1995 |g 5(1999), 5, Seite 554-559 |h Online-Ressource |w (DE-627)301511640 |w (DE-600)1484517-9 |w (DE-576)288571274 |x 1546-170X |7 nnas |a NF-κB is activated and promotes cell death in focal cerebral ischemia |
| 773 | 1 | 8 | |g volume:5 |g year:1999 |g number:5 |g pages:554-559 |g extent:6 |a NF-κB is activated and promotes cell death in focal cerebral ischemia |
| 856 | 4 | 0 | |u https://doi.org/10.1038/8432 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/nm0599_554 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210401 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 1028374909 |a Schwaninger, Markus |m 1028374909:Schwaninger, Markus |d 910000 |d 911100 |e 910000PS1028374909 |e 911100PS1028374909 |k 0/910000/ |k 1/910000/911100/ |p 6 |y j | ||
| 998 | |g 120356775 |a Schneider, Armin |m 120356775:Schneider, Armin |d 50000 |e 50000PS120356775 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1753064309 |e 3901363971 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"1999","dateIssuedKey":"1999"}],"titleAlt":[{"title":"NF-kappaB is activated and promotes cell death in focal cerebral ischemia"},{"title":"NF-kappa B is activated and promotes cell death in focal cerebral ischemia"}],"relHost":[{"pubHistory":["1.1995 -"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"6","issue":"5","volume":"5","year":"1999","text":"5(1999), 5, Seite 554-559","pages":"554-559"},"title":[{"title_sort":"Nature medicine","title":"Nature medicine"}],"disp":"NF-κB is activated and promotes cell death in focal cerebral ischemiaNature medicine","recId":"301511640","id":{"zdb":["1484517-9"],"issn":["1546-170X"],"eki":["301511640"]},"origin":[{"dateIssuedKey":"2017","publisher":"Springer Nature ; Nature America Inc.","dateIssuedDisp":"2017-","publisherPlace":"[New York, NY] ; New York, NY"}],"note":["Gesehen am 24. Juli 2018"],"physDesc":[{"extent":"Online-Ressource"}]}],"id":{"doi":["10.1038/8432"],"eki":["1753064309"]},"physDesc":[{"extent":"6 S."}],"person":[{"roleDisplay":"VerfasserIn","family":"Schneider","display":"Schneider, Armin","role":"aut","given":"Armin"},{"role":"aut","display":"Martín-Villalba, Ana","given":"Ana","family":"Martín-Villalba","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Weih","given":"Falk","role":"aut","display":"Weih, Falk"},{"family":"Vogel","roleDisplay":"VerfasserIn","given":"Johannes","display":"Vogel, Johannes","role":"aut"},{"family":"Wirth","roleDisplay":"VerfasserIn","role":"aut","display":"Wirth, Thomas","given":"Thomas"},{"roleDisplay":"VerfasserIn","family":"Schwaninger","given":"Markus","display":"Schwaninger, Markus","role":"aut"}],"note":["Gesehen am 01.04.2021"],"name":{"displayForm":["Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth & Markus Schwaninger"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1753064309","title":[{"title":"NF-κB is activated and promotes cell death in focal cerebral ischemia","title_sort":"NF-κB is activated and promotes cell death in focal cerebral ischemia"}]} | ||
| SRT | |a SCHNEIDERANFBISACTIV1999 | ||