NF-κB is activated and promotes cell death in focal cerebral ischemia
The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
Nature medicine
Year: 1999, Jahrgang: 5, Heft: 5, Pages: 554-559 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/8432 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/8432 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm0599_554 
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| Verfasserangaben: | Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth & Markus Schwaninger |
| Zusammenfassung: | The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter transgene, nuclear translocation of NF-κB in neurons and enhanced DNA binding of NF-κB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-κB in focal ischemia. NF-κB may provide a new pharmacological target in neurologic disease. |
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| Beschreibung: | Gesehen am 01.04.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-170X |
| DOI: | 10.1038/8432 |