Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion oncoproteins involving EWSR1 and variable members of the ETS-family of transcription factors (in 85% FLI1). EWSR1-FLI1 can induce targ...

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Main Authors:	Marchetto, Aruna (Author) , Ohmura, Shunya (Author) , Orth, Martin F. (Author) , Knott, Maximilian M. L. (Author) , Colombo, Maria V. (Author) , Arrigoni, Chiara (Author) , Bardinet, Victor (Author) , Saucier, David (Author) , Wehweck, Fabienne S. (Author) , Li, Jing (Author) , Stein, Stefanie (Author) , Gerke, Julia S. (Author) , Baldauf, Michaela C. (Author) , Musa, Julian (Author) , Dallmayer, Marlene (Author) , Romero-Pérez, Laura (Author) , Hölting, Tilman (Author) , Amatruda, James F. (Author) , Cossarizza, Andrea (Author) , Henssen, Anton G. (Author) , Kirchner, Thomas (Author) , Moretti, Matteo (Author) , Cidre-Aranaz, Florencia (Author) , Sannino, Giuseppina (Author) , Grünewald, Thomas G. P. (Author)
Format:	Article (Journal)
Language:	English
Published:	15 May 2020
In:	Nature Communications Year: 2020, Volume: 11, Pages: 1-16
ISSN:	2041-1723
DOI:	10.1038/s41467-020-16244-2
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-16244-2 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-16244-2
Author Notes:	Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M.L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L.B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino & Thomas G.P. Grünewald