An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death
<p>The CD95 (APO-1/Fas) system plays a critical role in activation-induced cell death (AICD) of T cells. We previously described two distinct CD95 (APO-1/Fas) signaling pathways: 1) type I cells show strong death-inducing signaling complex (DISC) formation and mitochondria-independent apoptosi...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 5, 2003
|
| In: |
The journal of immunology
Year: 2003, Jahrgang: 171, Heft: 6, Pages: 2930-2936 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.171.6.2930 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.171.6.2930 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/171/6/2930 
|
| Verfasserangaben: | Ingo Schmitz, Andreas Krueger, Sven Baumann, Henning Schulze-Bergkamen, Peter H. Krammer, and Sabine Kirchhoff |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1753241650 | ||
| 003 | DE-627 | ||
| 005 | 20220819155047.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210407s2003 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.171.6.2930 |2 doi | |
| 035 | |a (DE-627)1753241650 | ||
| 035 | |a (DE-599)KXP1753241650 | ||
| 035 | |a (OCoLC)1341403614 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmitz, Ingo |d 1971- |e VerfasserIn |0 (DE-588)122317068 |0 (DE-627)705859169 |0 (DE-576)293216517 |4 aut | |
| 245 | 1 | 3 | |a An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death |c Ingo Schmitz, Andreas Krueger, Sven Baumann, Henning Schulze-Bergkamen, Peter H. Krammer, and Sabine Kirchhoff |
| 264 | 1 | |c September 5, 2003 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.04.2021 | ||
| 520 | |a <p>The CD95 (APO-1/Fas) system plays a critical role in activation-induced cell death (AICD) of T cells. We previously described two distinct CD95 (APO-1/Fas) signaling pathways: 1) type I cells show strong death-inducing signaling complex (DISC) formation and mitochondria-independent apoptosis and 2) DISC formation is reduced in type II cells, leading to mitochondria-dependent apoptosis. To investigate the relevance of these pathways, we set up an in vitro model that mimics the initiation and the down phase of an immune response, respectively. Freshly activated human T cells (initiation) are resistant toward CD95-mediated AICD despite high expression of CD95. We previously reported that these T cells show reduced DISC formation. In this study, we show that freshly activated T cells are CD95-type II cells that show high expression levels of Bcl-x<sub>L</sub> and display a block in the mitochondrial apoptosis pathway. Furthermore, we show that, upon prolonged culture (down phase), human T cells undergo a switch from type II to type I cells that renders T cells sensitive to CD95-mediated AICD. Finally, we demonstrate that this switch is dependent on the presence of IL-2. Our observations reveal for the first time that the existence of coexisting CD95 signaling pathways is of physiological relevance.</p> | ||
| 700 | 1 | |a Schulze-Bergkamen, Henning |d 1971- |e VerfasserIn |0 (DE-588)120914387 |0 (DE-627)080966403 |0 (DE-576)292444907 |4 aut | |
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 171(2003), 6, Seite 2930-2936 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death |
| 773 | 1 | 8 | |g volume:171 |g year:2003 |g number:6 |g pages:2930-2936 |g extent:7 |a An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.171.6.2930 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jimmunol.org/content/171/6/2930 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210407 | ||
| 993 | |a Article | ||
| 994 | |a 2003 | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 5 | ||
| 998 | |g 120914387 |a Schulze-Bergkamen, Henning |m 120914387:Schulze-Bergkamen, Henning |d 50000 |e 50000PS120914387 |k 0/50000/ |p 4 | ||
| 999 | |a KXP-PPN1753241650 |e 3903040355 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"extent":"7","text":"171(2003), 6, Seite 2930-2936","volume":"171","issue":"6","pages":"2930-2936","year":"2003"},"pubHistory":["1.1916 -"],"recId":"269535217","corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"American Association of Immunologists"}],"language":["eng"],"disp":"An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell deathThe journal of immunology","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 18.08.2025"],"title":[{"title_sort":"journal of immunology","title":"The journal of immunology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1550-6606"],"zdb":["1475085-5"],"eki":["269535217"]},"origin":[{"publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md.","dateIssuedKey":"2025","publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedDisp":"2025-"}],"name":{"displayForm":["American Association of Immunologists"]}}],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Ingo Schmitz, Andreas Krueger, Sven Baumann, Henning Schulze-Bergkamen, Peter H. Krammer, and Sabine Kirchhoff"]},"id":{"doi":["10.4049/jimmunol.171.6.2930"],"eki":["1753241650"]},"origin":[{"dateIssuedDisp":"September 5, 2003","dateIssuedKey":"2003"}],"language":["eng"],"recId":"1753241650","note":["Gesehen am 07.04.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"display":"Schmitz, Ingo","roleDisplay":"VerfasserIn","role":"aut","family":"Schmitz","given":"Ingo"},{"given":"Henning","family":"Schulze-Bergkamen","role":"aut","display":"Schulze-Bergkamen, Henning","roleDisplay":"VerfasserIn"},{"family":"Krammer","given":"Peter H.","roleDisplay":"VerfasserIn","display":"Krammer, Peter H.","role":"aut"}],"title":[{"title":"An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death","title_sort":"IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death"}]} | ||
| SRT | |a SCHMITZINGIL2DEPENDE5200 | ||