Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra
Both endocannabinoids through cannabinoid receptor type I (CB1) receptors and dopamine through dopamine receptor type D1 receptors modulate postsynaptic inhibition in substantia nigra by changing GABA release from striatonigral terminals. By recording from visually identified pars compacta and pars...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 October 2003
|
| In: |
Neuroscience
Year: 2003, Volume: 122, Issue: 2, Pages: 317-328 |
| ISSN: | 1873-7544 |
| DOI: | 10.1016/S0306-4522(03)00607-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0306-4522(03)00607-9 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306452203006079 
|
| Author Notes: | Y. Yanovsky, S. Mades and U. Misgeld |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1753321700 | ||
| 003 | DE-627 | ||
| 005 | 20240413193251.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210408s2003 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S0306-4522(03)00607-9 |2 doi | |
| 035 | |a (DE-627)1753321700 | ||
| 035 | |a (DE-599)KXP1753321700 | ||
| 035 | |a (OCoLC)1341403714 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Yanovsky, Yevgenij |e VerfasserIn |0 (DE-588)1059175789 |0 (DE-627)798124377 |0 (DE-576)415191165 |4 aut | |
| 245 | 1 | 0 | |a Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra |c Y. Yanovsky, S. Mades and U. Misgeld |
| 264 | 1 | |c 23 October 2003 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.04.2021 | ||
| 520 | |a Both endocannabinoids through cannabinoid receptor type I (CB1) receptors and dopamine through dopamine receptor type D1 receptors modulate postsynaptic inhibition in substantia nigra by changing GABA release from striatonigral terminals. By recording from visually identified pars compacta and pars reticulata neurons we searched for a possible co-release and interaction of endocannabinoids and dopamine. Depolarization of a neuron in pars reticulata or in pars compacta transiently suppressed evoked synaptic currents which were blocked by GABAA receptor antagonists (inhibitory postsynaptic currents [IPSCs]). This depolarization-induced suppression of inhibition (DSI) was abrogated by the cannabinoid CB1 receptor antagonist AM251 (1 μM). A correlation existed between the degree of DSI and the degree of reduction of evoked IPSCs by the CB1 receptor agonist WIN55,212-2 (1 μM). The cholinergic receptor agonist carbachol (0.5-5 μM) enhanced DSI, but suppression of spontaneous IPSCs was barely detectable pointing to the existence of GABA release sites without CB1 receptors. In dopamine, but not in GABAergic neurons DSI was enhanced by the dopamine D1 receptor antagonist SCH23390 (3-10 μM). Both the antagonist for CB1 receptors and the antagonist for dopamine D1 receptors enhanced or reduced, respectively, the amplitudes of evoked IPSCs. This tonic influence persisted if the receptor for the other ligand was blocked. We conclude that endocannabinoids and dopamine can be co-released. Retrograde signaling through endocannabinoids and dopamine changes inhibition independently from each other. Activation of dopamine D1 receptors emphasizes extrinsic inhibition and activation of CB1 receptors promotes intrinsic inhibition. | ||
| 650 | 4 | |a cannabinoid CB1 receptors | |
| 650 | 4 | |a dopamine | |
| 650 | 4 | |a dopamine D1 receptors | |
| 650 | 4 | |a endocannabinoids | |
| 650 | 4 | |a GABA | |
| 700 | 1 | |a Mades, Sandra Hedwig |d 1976- |e VerfasserIn |0 (DE-588)129033839 |0 (DE-627)38788579X |0 (DE-576)297458523 |4 aut | |
| 700 | 1 | |a Misgeld, Ulrich |d 1943- |e VerfasserIn |0 (DE-588)1020794321 |0 (DE-627)691350418 |0 (DE-576)362039666 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuroscience |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 122(2003), 2, Seite 317-328 |h Online-Ressource |w (DE-627)306588625 |w (DE-600)1498423-4 |w (DE-576)081953089 |x 1873-7544 |7 nnas |a Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra |
| 773 | 1 | 8 | |g volume:122 |g year:2003 |g number:2 |g pages:317-328 |g extent:10 |a Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0306-4522(03)00607-9 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0306452203006079 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210408 | ||
| 993 | |a Article | ||
| 994 | |a 2003 | ||
| 998 | |g 1020794321 |a Misgeld, Ulrich |m 1020794321:Misgeld, Ulrich |d 50000 |d 53200 |e 50000PM1020794321 |e 53200PM1020794321 |k 0/50000/ |k 1/50000/53200/ |p 3 |y j | ||
| 999 | |a KXP-PPN1753321700 |e 3903254940 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1753321700"],"doi":["10.1016/S0306-4522(03)00607-9"]},"physDesc":[{"extent":"10 S."}],"note":["Gesehen am 08.04.2021"],"relHost":[{"pubHistory":["1.1976 -"],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"International Brain Research Organization"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"issue":"2","pages":"317-328","volume":"122","extent":"10","year":"2003","text":"122(2003), 2, Seite 317-328"},"id":{"issn":["1873-7544"],"eki":["306588625"],"zdb":["1498423-4"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 20.02.20"],"title":[{"title_sort":"Neuroscience","subtitle":"an international journal under the editorial direction of IBRO","title":"Neuroscience"}],"language":["eng"],"recId":"306588625","origin":[{"dateIssuedKey":"1976","publisher":"Elsevier Science","dateIssuedDisp":"1976-","publisherPlace":"Amsterdam [u.a.]"}],"disp":"Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigraNeuroscience"}],"title":[{"title":"Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra","title_sort":"Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra"}],"recId":"1753321700","origin":[{"dateIssuedKey":"2003","dateIssuedDisp":"23 October 2003"}],"person":[{"family":"Yanovsky","display":"Yanovsky, Yevgenij","given":"Yevgenij","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Mades","display":"Mades, Sandra Hedwig","role":"aut","given":"Sandra Hedwig","roleDisplay":"VerfasserIn"},{"display":"Misgeld, Ulrich","family":"Misgeld","role":"aut","given":"Ulrich","roleDisplay":"VerfasserIn"}],"language":["eng"],"name":{"displayForm":["Y. Yanovsky, S. Mades and U. Misgeld"]}} | ||
| SRT | |a YANOVSKYYERETROGRADE2320 | ||