Cover Image

Gpr177 regulates pulmonary vasculature development

Skip to Next Section - Establishment of the functional pulmonary vasculature requires intimate interaction between the epithelium and mesenchyme. Previous genetic studies have led to inconsistent conclusions about the contribution of epithelial Wnts to pulmonary vasculature development. This discrep...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiang, Ming (Author) , Ku, Wei-yao (Author) , Fu, Jiang (Author) , Offermanns, Stefan (Author) , Hsu, Wei (Author) , Que, Jianwen (Author)
Format: Article (Journal)
Language:English
Published: July 24, 2013
In: Development
Year: 2013, Volume: 140, Issue: 17, Pages: 3589-3594
ISSN:1477-9129
DOI:10.1242/dev.095471
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/dev.095471
Verlag, lizenzpflichtig, Volltext: https://dev.biologists.org/content/140/17/3589
Get full text
Author Notes:Ming Jiang, Wei-yao Ku, Jiang Fu, Stefan Offermanns, Wei Hsu and Jianwen Que

MARC

LEADER 00000caa a2200000 c 4500
001 1753327768
003 DE-627
005 20230426165452.0
007 cr uuu---uuuuu
008 210408s2013 xx |||||o 00| ||eng c
024 7 |a 10.1242/dev.095471  |2 doi 
035 |a (DE-627)1753327768 
035 |a (DE-599)KXP1753327768 
035 |a (OCoLC)1341403658 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Jiang, Ming  |e VerfasserIn  |0 (DE-588)1230994750  |0 (DE-627)1753326494  |4 aut 
245 1 0 |a Gpr177 regulates pulmonary vasculature development  |c Ming Jiang, Wei-yao Ku, Jiang Fu, Stefan Offermanns, Wei Hsu and Jianwen Que 
264 1 |c July 24, 2013 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.04.2021 
520 |a Skip to Next Section - Establishment of the functional pulmonary vasculature requires intimate interaction between the epithelium and mesenchyme. Previous genetic studies have led to inconsistent conclusions about the contribution of epithelial Wnts to pulmonary vasculature development. This discrepancy is possibly due to the functional redundancy among different Wnts. Here, we use Shh-Cre to conditionally delete Gpr177 (the mouse ortholog of Drosophila Wntless, Wls), a chaperon protein important for the sorting and secretion of Wnt proteins. Deletion of epithelial Gpr177 reduces Wnt signaling activity in both the epithelium and mesenchyme, resulting in severe hemorrhage and abnormal vasculature, accompanied by branching defects and abnormal epithelial differentiation. We then used multiple mouse models to demonstrate that Wnt/β-catenin signaling is not only required for the proliferation and differentiation of mesenchyme, but also is important for the maintenance of smooth muscle cells through the regulation of the transcription factor Kruppel-like factor 2 (Klf2). Together, our studies define a novel mechanism by which epithelial Wnts regulate the normal development and maintenance of pulmonary vasculature. These findings provide insight into the pathobiology of congenital lung diseases, such as alveolar capillary dysplasia (ACD), that have abnormal alveolar development and dysmorphic pulmonary vasculature. 
700 1 |a Ku, Wei-yao  |e VerfasserIn  |4 aut 
700 1 |a Fu, Jiang  |e VerfasserIn  |4 aut 
700 1 |a Offermanns, Stefan  |d 1964-  |e VerfasserIn  |0 (DE-588)113037279  |0 (DE-627)584488734  |0 (DE-576)289750113  |4 aut 
700 1 |a Hsu, Wei  |e VerfasserIn  |4 aut 
700 1 |a Que, Jianwen  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Development  |d Cambridge : The Company of Biologists, 1987  |g 140(2013), 17, Seite 3589-3594  |h Online-Ressource  |w (DE-627)31982439X  |w (DE-600)2007916-3  |w (DE-576)090893131  |x 1477-9129  |7 nnas  |a Gpr177 regulates pulmonary vasculature development 
773 1 8 |g volume:140  |g year:2013  |g number:17  |g pages:3589-3594  |g extent:6  |a Gpr177 regulates pulmonary vasculature development 
787 0 8 |i Errata  |a Jiang, Ming  |t Corrigendum: Gpr177 regulates pulmonary vasculature development  |d 2013  |w (DE-627)1753380596 
856 4 0 |u https://doi.org/10.1242/dev.095471  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://dev.biologists.org/content/140/17/3589  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210408 
993 |a Article 
994 |a 2013 
998 |g 113037279  |a Offermanns, Stefan  |m 113037279:Offermanns, Stefan  |p 4 
999 |a KXP-PPN1753327768  |e 390326833X 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1753327768"],"doi":["10.1242/dev.095471"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"July 24, 2013"}],"name":{"displayForm":["Ming Jiang, Wei-yao Ku, Jiang Fu, Stefan Offermanns, Wei Hsu and Jianwen Que"]},"relHost":[{"name":{"displayForm":["Company of Biologists"]},"id":{"eki":["31982439X"],"zdb":["2007916-3"],"issn":["1477-9129"]},"origin":[{"publisherPlace":"Cambridge","publisher":"The Company of Biologists","dateIssuedKey":"1987","dateIssuedDisp":"1987-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Development","title_sort":"Development"}],"corporate":[{"display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"recId":"31982439X","disp":"Gpr177 regulates pulmonary vasculature developmentDevelopment","note":["Gesehen am 26.06.2025"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"extent":"6","text":"140(2013), 17, Seite 3589-3594","volume":"140","issue":"17","pages":"3589-3594","year":"2013"},"titleAlt":[{"title":"Development <Cambridge>"}],"pubHistory":["Volume 99, 1 (January 1987)-"]}],"physDesc":[{"extent":"6 S."}],"title":[{"title_sort":"Gpr177 regulates pulmonary vasculature development","title":"Gpr177 regulates pulmonary vasculature development"}],"person":[{"family":"Jiang","given":"Ming","display":"Jiang, Ming","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Ku, Wei-yao","roleDisplay":"VerfasserIn","given":"Wei-yao","family":"Ku"},{"given":"Jiang","family":"Fu","role":"aut","display":"Fu, Jiang","roleDisplay":"VerfasserIn"},{"family":"Offermanns","given":"Stefan","roleDisplay":"VerfasserIn","display":"Offermanns, Stefan","role":"aut"},{"given":"Wei","family":"Hsu","role":"aut","roleDisplay":"VerfasserIn","display":"Hsu, Wei"},{"roleDisplay":"VerfasserIn","display":"Que, Jianwen","role":"aut","family":"Que","given":"Jianwen"}],"language":["eng"],"recId":"1753327768","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.04.2021"]} 
SRT |a JIANGMINGKGPR177REGU2420 

Similar Items