Buchumschlag

The role of chromatin remodeling in medulloblastoma

The unexpectedly high frequency and universality of alterations to the chromatin machinery is one of the most striking themes emerging from the current deluge of cancer genomics data. Medulloblastoma (MB), a malignant pediatric brain tumor, is no exception to this trend, with a wealth of recent stud...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jones, David T. W. (VerfasserIn) , Northcott, Paul A. (VerfasserIn) , Kool, Marcel (VerfasserIn) , Pfister, Stefan (VerfasserIn)
Dokumenttyp: Article (Journal) Konferenzschrift
Sprache:Englisch
Veröffentlicht: 25 February 2013
In: Brain pathology
Year: 2013, Jahrgang: 23, Heft: 2, Pages: 193-199
ISSN:1750-3639
DOI:https://doi.org/10.1111/bpa.12019
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/bpa.12019
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12019
Volltext
Verfasserangaben:David T.W. Jones; Paul A. Northcott; Marcel Kool; Stefan M. Pfister

MARC

LEADER 00000caa a2200000 c 4500
001 1753552540
003 DE-627
005 20220819160926.0
007 cr uuu---uuuuu
008 210409s2013 xx |||||o 00| ||eng c
024 7 |a 10.1111/bpa.12019  |2 doi 
035 |a (DE-627)1753552540 
035 |a (DE-599)KXP1753552540 
035 |a (OCoLC)1341403937 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Jones, David T. W.  |e VerfasserIn  |0 (DE-588)1058669672  |0 (DE-627)79739334X  |0 (DE-576)414823583  |4 aut 
245 1 4 |a The role of chromatin remodeling in medulloblastoma  |c David T.W. Jones; Paul A. Northcott; Marcel Kool; Stefan M. Pfister 
264 1 |c 25 February 2013 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 09.04.2021 
500 |a Mini-symposium: When genetics meets epigenetics - a new option for therapeutic intervention in brain tumors? 
520 |a The unexpectedly high frequency and universality of alterations to the chromatin machinery is one of the most striking themes emerging from the current deluge of cancer genomics data. Medulloblastoma (MB), a malignant pediatric brain tumor, is no exception to this trend, with a wealth of recent studies indicating multiple alterations at all levels of chromatin processing. MB is typically now regarded as being composed of four major molecular entities (WNT, SHH, Group 3 and Group 4), which vary in their clinical and biological characteristics. Similarities and differences across these subgroups are also reflected in the specific chromatin modifiers that are found to be altered in each group, and each new cancer genome sequence or microarray profile is adding to this important knowledge base. These data are fundamentally changing our understanding of tumor developmental pathways, not just for MB but also for cancer as a whole. They also provide a new class of targets for the development of rational, personalized therapeutic approaches. The mechanisms by which these chromatin remodelers are dysregulated in MB, and the consequences both for future basic research and for translation to the clinic, will be examined here. 
650 4 |a chromatin 
650 4 |a epigenetics 
650 4 |a histone 
650 4 |a medulloblastoma. 
700 1 |a Northcott, Paul A.  |e VerfasserIn  |0 (DE-588)1081957883  |0 (DE-627)846917017  |0 (DE-576)45498393X  |4 aut 
700 1 |a Kool, Marcel  |e VerfasserIn  |0 (DE-588)1058669753  |0 (DE-627)797393560  |0 (DE-576)414823842  |4 aut 
700 1 |a Pfister, Stefan  |d 1974-  |e VerfasserIn  |0 (DE-588)123850215  |0 (DE-627)706450930  |0 (DE-576)293908400  |4 aut 
773 0 8 |i Enthalten in  |t Brain pathology  |d Oxford : Wiley-Blackwell, 1990  |g 23(2013), 2 vom: März, Seite 193-199  |w (DE-627)324660677  |w (DE-600)2029927-8  |w (DE-576)098546325  |x 1750-3639  |7 nnas  |a The role of chromatin remodeling in medulloblastoma 
773 1 8 |g volume:23  |g year:2013  |g number:2  |g month:03  |g pages:193-199  |g extent:7  |a The role of chromatin remodeling in medulloblastoma 
856 4 0 |u https://doi.org/https://doi.org/10.1111/bpa.12019  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12019  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210409 
993 |a ConferencePaper 
994 |a 2013 
998 |g 123850215  |a Pfister, Stefan  |m 123850215:Pfister, Stefan  |d 50000  |e 50000PP123850215  |k 0/50000/  |p 4  |y j 
998 |g 1058669753  |a Kool, Marcel  |m 1058669753:Kool, Marcel  |d 50000  |e 50000PK1058669753  |k 0/50000/  |p 3 
998 |g 1081957883  |a Northcott, Paul A.  |m 1081957883:Northcott, Paul A.  |p 2 
998 |g 1058669672  |a Jones, David T. W.  |m 1058669672:Jones, David T. W.  |d 50000  |e 50000PJ1058669672  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1753552540  |e 3904240633 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1753552540","language":["eng"],"id":{"eki":["1753552540"],"doi":["10.1111/bpa.12019"]},"physDesc":[{"extent":"7 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 09.04.2021","Mini-symposium: When genetics meets epigenetics - a new option for therapeutic intervention in brain tumors?"],"title":[{"title":"The role of chromatin remodeling in medulloblastoma","title_sort":"role of chromatin remodeling in medulloblastoma"}],"person":[{"roleDisplay":"VerfasserIn","display":"Jones, David T. W.","family":"Jones","role":"aut","given":"David T. W."},{"roleDisplay":"VerfasserIn","display":"Northcott, Paul A.","family":"Northcott","role":"aut","given":"Paul A."},{"family":"Kool","display":"Kool, Marcel","roleDisplay":"VerfasserIn","role":"aut","given":"Marcel"},{"given":"Stefan","role":"aut","roleDisplay":"VerfasserIn","family":"Pfister","display":"Pfister, Stefan"}],"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"25 February 2013"}],"name":{"displayForm":["David T.W. Jones; Paul A. Northcott; Marcel Kool; Stefan M. Pfister"]},"relHost":[{"language":["eng"],"id":{"issn":["1750-3639"],"zdb":["2029927-8"],"eki":["324660677"],"doi":["10.1111/(ISSN)1750-3639"]},"recId":"324660677","origin":[{"publisher":"Wiley-Blackwell ; International Society of Neuropathology ; Blackwell","dateIssuedDisp":"1990-","publisherPlace":"Oxford ; [Erscheinungsort nicht ermittelbar] ; Oxford","dateIssuedKey":"1990"}],"disp":"The role of chromatin remodeling in medulloblastomaBrain pathology","pubHistory":["1.1990/91 -"],"part":{"year":"2013","issue":"2","extent":"7","text":"23(2013), 2 vom: März, Seite 193-199","volume":"23","pages":"193-199"},"note":["Gesehen am 23.09.2021"],"title":[{"subtitle":"the official journal of the International Society of Neuropathology","title":"Brain pathology","title_sort":"Brain pathology"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}]} 
SRT |a JONESDAVIDROLEOFCHRO2520 

Ähnliche Einträge