Biomarker testing in non-small cell lung cancer in routine care: analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315)
Objectives - An increasing number of treatment-determining biomarkers has been identified in non-small cell lung cancer (NSCLC) and molecular testing is recommended to enable optimal individualized treatment. However, data on implementation of these recommendations in the “real-world” setting are sc...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
|
| In: |
Lung cancer
Year: 2020, Volume: 152, Pages: 174-184 |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2020.10.012 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lungcan.2020.10.012 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0169500220306632 
|
| Author Notes: | Frank Griesinger, Wilfried Eberhardt, Arnd Nusch, Marcel Reiser, Mark-Oliver Zahn, Christoph Maintz, Christiane Bernhardt, Christoph Losem, Albrecht Stenzinger, Lukas C. Heukamp, Reinhard Büttner, Norbert Marschner, Martina Jänicke, Annette Fleitz, Lisa Spring, Jörg Sahlmann, Aysun Karatas, Annette Hipper, Wilko Weichert, Monika Heilmann, Parvis Sadjadian, Wolfgang Gleiber, Christian Grah, Cornelius F. Waller, Martin Reck, Achim Rittmeyer, Petros Christopoulos, Martin Sebastian, Michael Thomas, the CRISP Registry Group |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1753975859 | ||
| 003 | DE-627 | ||
| 005 | 20241230010705.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210413r20212020xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.lungcan.2020.10.012 |2 doi | |
| 035 | |a (DE-627)1753975859 | ||
| 035 | |a (DE-599)KXP1753975859 | ||
| 035 | |a (OCoLC)1341404233 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Griesinger, Frank |e VerfasserIn |0 (DE-588)1080408916 |0 (DE-627)844436305 |0 (DE-576)453541747 |4 aut | |
| 245 | 1 | 0 | |a Biomarker testing in non-small cell lung cancer in routine care |b analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315) |c Frank Griesinger, Wilfried Eberhardt, Arnd Nusch, Marcel Reiser, Mark-Oliver Zahn, Christoph Maintz, Christiane Bernhardt, Christoph Losem, Albrecht Stenzinger, Lukas C. Heukamp, Reinhard Büttner, Norbert Marschner, Martina Jänicke, Annette Fleitz, Lisa Spring, Jörg Sahlmann, Aysun Karatas, Annette Hipper, Wilko Weichert, Monika Heilmann, Parvis Sadjadian, Wolfgang Gleiber, Christian Grah, Cornelius F. Waller, Martin Reck, Achim Rittmeyer, Petros Christopoulos, Martin Sebastian, Michael Thomas, the CRISP Registry Group |
| 264 | 1 | |c 2021 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 2 November 2020 | ||
| 500 | |a Gesehen am 13.04.2021 | ||
| 520 | |a Objectives - An increasing number of treatment-determining biomarkers has been identified in non-small cell lung cancer (NSCLC) and molecular testing is recommended to enable optimal individualized treatment. However, data on implementation of these recommendations in the “real-world” setting are scarce. This study presents comprehensive details on the frequency, methodology and results of biomarker testing of advanced NSCLC in Germany. - Patients and methods - This analysis included 3,717 patients with advanced NSCLC (2,921 non-squamous; 796 squamous), recruited into the CRISP registry at start of systemic therapy by 150 German sites between December 2015 and June 2019. Evaluated were the molecular biomarkers EGFR, ALK, ROS1, BRAF, KRAS, MET, TP53, RET, HER2, as well as expression of PD-L1. - Results - In total, 90.5 % of the patients were tested for biomarkers. Testing rates were 92.2 % (non-squamous), 70.7 % (squamous) and increased from 83.2 % in 2015/16 to 94.2% in 2019. Overall testing rates for EGFR, ALK, ROS1, and BRAF were 72.5 %, 74.5 %, 66.1 %, and 53.0 %, respectively (non-squamous). Testing rates for PD-L1 expression were 64.5 % (non-squamous), and 58.5 % (squamous). The most common testing methods were immunohistochemistry (68.5 % non-squamous, 58.3 % squamous), and next-generation sequencing (38.7 % non-squamous, 14.4 % squamous). Reasons for not testing were insufficient tumor material or lack of guideline recommendations (squamous). No alteration was found in 37.8 % (non-squamous), and 57.9 % (squamous), respectively. Most common alterations in non-squamous tumors (all patients/all patients tested for the respective biomarker): KRAS (17.3 %/39.2 %), TP53 (14.1 %/51.4 %), and EGFR (11.0 %/15.1 %); in squamous tumors: TP53 (7.0 %/69.1 %), MET (1.5 %/11.1 %), and EGFR (1.1 %/4.4 %). Median PFS (non-squamous) was 8.7 months (95 % CI 7.4-10.4) with druggable EGFR mutation, and 8.0 months (95 % CI 3.9-9.2) with druggable ALK alterations. - Conclusion - Testing rates in Germany are high nationwide and acceptable in international comparison, but still leave out a significant portion of patients, who could potentially benefit. Thus, specific measures are needed to increase implementation. | ||
| 534 | |c 2020 | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Cohort studies | |
| 650 | 4 | |a Molecular diagnostic testing | |
| 650 | 4 | |a Non-small cell lung cancer | |
| 650 | 4 | |a Registries | |
| 700 | 1 | |8 1\p |a Eberhardt, Wilfried E. E. |e VerfasserIn |0 (DE-588)1058450573 |0 (DE-627)796897654 |0 (DE-576)414636554 |4 aut | |
| 700 | 1 | |8 2\p |a Nusch, Arnd |d 1963- |e VerfasserIn |0 (DE-588)121031276 |0 (DE-627)705175731 |0 (DE-576)292506333 |4 aut | |
| 700 | 1 | |a Reiser, Marcel |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Zahn, Mark-Oliver |d 1965- |e VerfasserIn |0 (DE-588)123774713 |0 (DE-627)706422821 |0 (DE-576)293872848 |4 aut | |
| 700 | 1 | |a Maintz, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bernhardt, Christiane |e VerfasserIn |4 aut | |
| 700 | 1 | |8 4\p |a Losem, Christoph |e VerfasserIn |0 (DE-588)103173452X |0 (DE-627)737251697 |0 (DE-576)379429349 |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |8 5\p |a Heukamp, Lukas |e VerfasserIn |0 (DE-588)1225306612 |0 (DE-627)174487266X |4 aut | |
| 700 | 1 | |8 6\p |a Büttner, Reinhard |d 1960- |e VerfasserIn |0 (DE-588)171994825 |0 (DE-627)696891301 |0 (DE-576)132870975 |4 aut | |
| 700 | 1 | |a Marschner, Norbert |e VerfasserIn |4 aut | |
| 700 | 1 | |8 7\p |a Jänicke, Martina |e VerfasserIn |0 (DE-588)138014930 |0 (DE-627)696271370 |0 (DE-576)306133695 |4 aut | |
| 700 | 1 | |a Fleitz, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spring, Lisa |e VerfasserIn |4 aut | |
| 700 | 1 | |8 8\p |a Sahlmann, Jörg |e VerfasserIn |0 (DE-588)1018619585 |0 (DE-627)682866229 |0 (DE-576)356082407 |4 aut | |
| 700 | 1 | |a Karatas, Aysun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hipper, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |8 9\p |a Weichert, Wilko |d 1970-2023 |e VerfasserIn |0 (DE-588)123509106 |0 (DE-627)56134650X |0 (DE-576)293740461 |4 aut | |
| 700 | 1 | |8 10\p |a Heilmann, Monika |d 1967- |e VerfasserIn |0 (DE-588)115870083 |0 (DE-627)077524209 |0 (DE-576)290123356 |4 aut | |
| 700 | 1 | |8 11\p |a Sadjadian, Parvis |d 1966- |e VerfasserIn |0 (DE-588)12330119X |0 (DE-627)706247981 |0 (DE-576)293645140 |4 aut | |
| 700 | 1 | |a Gleiber, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grah, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |8 12\p |a Waller, Cornelius |d 1964- |e VerfasserIn |0 (DE-588)104222708X |0 (DE-627)768468337 |0 (DE-576)393782425 |4 aut | |
| 700 | 1 | |8 13\p |a Reck, Martin |d 1965- |e VerfasserIn |0 (DE-588)137678711 |0 (DE-627)594837413 |0 (DE-576)30483873X |4 aut | |
| 700 | 1 | |8 14\p |a Rittmeyer, Achim |d 1965- |e VerfasserIn |0 (DE-588)122112091 |0 (DE-627)705776166 |0 (DE-576)293097909 |4 aut | |
| 700 | 1 | |a Christopoulos, Petros |d 1977- |e VerfasserIn |0 (DE-588)138659702 |0 (DE-627)604886756 |0 (DE-576)308488067 |4 aut | |
| 700 | 1 | |8 15\p |a Sebastian, Martin |d 1965- |e VerfasserIn |0 (DE-588)129885916 |0 (DE-627)482779640 |0 (DE-576)297886975 |4 aut | |
| 700 | 1 | |a Thomas, Michael |e VerfasserIn |0 (DE-588)1054438781 |0 (DE-627)79152213X |0 (DE-576)41027089X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Lung cancer |d Amsterdam [u.a.] : Elsevier, 1985 |g 152(2021) vom: Feb., Seite 174-184 |h Online-Ressource |w (DE-627)320649733 |w (DE-600)2025812-4 |w (DE-576)264627539 |x 1872-8332 |7 nnas |a Biomarker testing in non-small cell lung cancer in routine care analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315) |
| 773 | 1 | 8 | |g volume:152 |g year:2021 |g month:02 |g pages:174-184 |g extent:11 |a Biomarker testing in non-small cell lung cancer in routine care analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315) |
| 787 | 0 | 8 | |i Errata |a Griesinger, Frank |t Corrigendum to “Biomarker testing in non-small cell lung cancer in routine care |d 2021 |w (DE-627)1763208532 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.lungcan.2020.10.012 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0169500220306632 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 8\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 9\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 10\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 11\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 12\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 13\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 14\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 15\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20210413 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1054438781 |a Thomas, Michael |m 1054438781:Thomas, Michael |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PT1054438781 |e 950000PT1054438781 |e 950900PT1054438781 |e 50000PT1054438781 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 29 |y j | ||
| 998 | |g 138659702 |a Christopoulos, Petros |m 138659702:Christopoulos, Petros |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PC138659702 |e 950000PC138659702 |e 950900PC138659702 |e 50000PC138659702 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 27 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 9 | ||
| 999 | |a KXP-PPN1753975859 |e 3906824098 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"origin":[{"dateIssuedKey":"1985","publisher":"Elsevier","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1985-"}],"id":{"eki":["320649733"],"issn":["1872-8332"],"zdb":["2025812-4"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"part":{"volume":"152","year":"2021","extent":"11","pages":"174-184","text":"152(2021) vom: Feb., Seite 174-184"},"title":[{"title_sort":"Lung cancer","title":"Lung cancer","subtitle":"journal of the International Association for the Study of Lung Cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Biomarker testing in non-small cell lung cancer in routine care analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315)Lung cancer","pubHistory":["1.1985 -"],"recId":"320649733","note":["Gesehen am 20.02.20"]}],"person":[{"given":"Frank","family":"Griesinger","display":"Griesinger, Frank","role":"aut"},{"given":"Wilfried E. E.","display":"Eberhardt, Wilfried E. E.","family":"Eberhardt","role":"aut"},{"role":"aut","given":"Arnd","display":"Nusch, Arnd","family":"Nusch"},{"role":"aut","given":"Marcel","family":"Reiser","display":"Reiser, Marcel"},{"role":"aut","given":"Mark-Oliver","family":"Zahn","display":"Zahn, Mark-Oliver"},{"role":"aut","display":"Maintz, Christoph","family":"Maintz","given":"Christoph"},{"display":"Bernhardt, Christiane","family":"Bernhardt","given":"Christiane","role":"aut"},{"role":"aut","given":"Christoph","family":"Losem","display":"Losem, Christoph"},{"given":"Albrecht","family":"Stenzinger","display":"Stenzinger, Albrecht","role":"aut"},{"role":"aut","given":"Lukas","display":"Heukamp, Lukas","family":"Heukamp"},{"given":"Reinhard","display":"Büttner, Reinhard","family":"Büttner","role":"aut"},{"role":"aut","given":"Norbert","display":"Marschner, Norbert","family":"Marschner"},{"given":"Martina","family":"Jänicke","display":"Jänicke, Martina","role":"aut"},{"given":"Annette","family":"Fleitz","display":"Fleitz, Annette","role":"aut"},{"given":"Lisa","display":"Spring, Lisa","family":"Spring","role":"aut"},{"role":"aut","given":"Jörg","display":"Sahlmann, Jörg","family":"Sahlmann"},{"family":"Karatas","display":"Karatas, Aysun","given":"Aysun","role":"aut"},{"family":"Hipper","display":"Hipper, Annette","given":"Annette","role":"aut"},{"display":"Weichert, Wilko","family":"Weichert","given":"Wilko","role":"aut"},{"given":"Monika","family":"Heilmann","display":"Heilmann, Monika","role":"aut"},{"display":"Sadjadian, Parvis","family":"Sadjadian","given":"Parvis","role":"aut"},{"role":"aut","given":"Wolfgang","family":"Gleiber","display":"Gleiber, Wolfgang"},{"role":"aut","given":"Christian","family":"Grah","display":"Grah, Christian"},{"given":"Cornelius","display":"Waller, Cornelius","family":"Waller","role":"aut"},{"family":"Reck","display":"Reck, Martin","given":"Martin","role":"aut"},{"display":"Rittmeyer, Achim","family":"Rittmeyer","given":"Achim","role":"aut"},{"given":"Petros","display":"Christopoulos, Petros","family":"Christopoulos","role":"aut"},{"display":"Sebastian, Martin","family":"Sebastian","given":"Martin","role":"aut"},{"role":"aut","display":"Thomas, Michael","family":"Thomas","given":"Michael"}],"physDesc":[{"extent":"11 S."}],"title":[{"title_sort":"Biomarker testing in non-small cell lung cancer in routine care","subtitle":"analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP registry (AIO-TRK-0315)","title":"Biomarker testing in non-small cell lung cancer in routine care"}],"language":["eng"],"id":{"doi":["10.1016/j.lungcan.2020.10.012"],"eki":["1753975859"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"2021"}],"recId":"1753975859","note":["Available online 2 November 2020","Gesehen am 13.04.2021"],"name":{"displayForm":["Frank Griesinger, Wilfried Eberhardt, Arnd Nusch, Marcel Reiser, Mark-Oliver Zahn, Christoph Maintz, Christiane Bernhardt, Christoph Losem, Albrecht Stenzinger, Lukas C. Heukamp, Reinhard Büttner, Norbert Marschner, Martina Jänicke, Annette Fleitz, Lisa Spring, Jörg Sahlmann, Aysun Karatas, Annette Hipper, Wilko Weichert, Monika Heilmann, Parvis Sadjadian, Wolfgang Gleiber, Christian Grah, Cornelius F. Waller, Martin Reck, Achim Rittmeyer, Petros Christopoulos, Martin Sebastian, Michael Thomas, the CRISP Registry Group"]}} | ||
| SRT | |a GRIESINGERBIOMARKERT2021 | ||