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Lovastatin induces mitotic abnormalities in various cell lines

We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G1phase, but also at the G2/M transition. After 24...

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Hauptverfasser: Lamprecht, Jan (VerfasserIn) , Paweletz, Neidhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 January 2013
In: Cell biology international
Year: 1999, Jahrgang: 23, Heft: 1, Pages: 51-60
ISSN:1095-8355
DOI:https://doi.org/10.1006/cbir.1998.0322
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1006/cbir.1998.0322
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1006/cbir.1998.0322
Volltext
Verfasserangaben:Jan Lamprecht, Cezary Wójcik, Marek Jakóbisiak, Michael Stoehr, Dieter Schroeter and Neidhard Paweletz

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520 |a We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G1phase, but also at the G2/M transition. After 24-48h incubation of epithelial PtK2, T24, HeLa cells and fibroblastic L929 cells in the presence of 1.0-60.0μm lovastatin, diverse mitotic perturbations have been observed. The most noteworthy phenomena recorded were prometaphase retardation and chromosome lagging during metaphase and anaphase. After the recovery in lovastatin-free media, the cells continued mitosis without any disturbances. Mevalonic acid prevented the effects of lovastatin. We conclude that the effects were specific for lovastatin-induced inhibition of mevalonic acid synthesis. Immunofluorescence studies with anticentromeric antibodies suggested that one of the possible causes of the lovastatin-induced mitotic disorder could be an interference with the development and function of the centromeres. 
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