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Gene expression analysis of vastus medialis cells after tourniquet-induced ischemia during total knee arthroplasty: a randomized clinical trial

Postoperative quadriceps muscle strength was lowered after tourniquet application during total knee arthroplasty (TKA). Furthermore, tourniquet application results in higher proteolytic activity within vastus medialis cells, without influence on the amount and function of mitochondria. The effects o...

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Bibliographic Details
Main Authors: Jawhar, Ahmed (Author) , Brenner, Desiree (Author) , Torre, Carolina de la (Author) , Sticht, Carsten (Author) , Obertacke, Udo (Author) , Ponelies, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: European journal of trauma and emergency surgery
Year: 2021, Volume: 47, Issue: 1, Pages: 233-240
ISSN:1863-9941
DOI:10.1007/s00068-019-01196-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00068-019-01196-0
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Author Notes:Ahmed Jawhar, Desiree Brenner, Carolina De La Torre, Carsten Sticht, Udo Obertacke, Norbert Ponelies
Description
Summary:Postoperative quadriceps muscle strength was lowered after tourniquet application during total knee arthroplasty (TKA). Furthermore, tourniquet application results in higher proteolytic activity within vastus medialis cells, without influence on the amount and function of mitochondria. The effects of the commonly utilized intraoperative tourniquet on gene expression within the human skeletal muscle cells are barely examined. The purpose of the present study was to analyze the gene expression within the skeletal muscle cells after tourniquet-induced ischemia to identify differential expressed genes (DEGs) and pathways.
Item Description:Gesehen am 19.04.2021
Published online: 5 August 2019
Physical Description:Online Resource
ISSN:1863-9941
DOI:10.1007/s00068-019-01196-0

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