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In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)

Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retr...

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Main Authors: John, Caroline (Author) , Dal Bello, Riccardo (Author) , Andratschke, Nicolaus (Author) , Guckenberger, Matthias (Author) , Boda-Heggemann, Judit (Author) , Gkika, Eleni (Author) , Mantel, Frederick (Author) , Specht, Hanno M. (Author) , Stromberger, Carmen (Author) , Zehentmayr, Franz (Author) , Blanck, Oliver (Author) , Balermpas, Panagiotis (Author)
Format: Article (Journal)
Language:English
Published: 25 February 2021
In: Scientific reports
Year: 2021, Volume: 11, Pages: 1-11
ISSN:2045-2322
DOI:10.1038/s41598-021-83210-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-021-83210-3
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-021-83210-3
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Author Notes:Caroline John, Riccardo Dal Bello, Nicolaus Andratschke, Matthias Guckenberger, Judit Boda-Heggemann, Eleni Gkika, Frederick Mantel, Hanno M. Specht, Carmen Stromberger, Franz Zehentmayr, Oliver Blanck, Panagiotis Balermpas
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Summary:Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm3, median PTV overlap 22 cm3. With a median interval of 20.2 months between the two SBRT-courses, 1-year OS, and -LCR were 78.3% and 70.3% respectively. 3 patients developed grade 1 and one grade 2 pneumonitis. No grade > 2 toxicity was observed. Peripheral location and dose were the only factors correlating with tumor control. A second SBRT-course with PTV overlap appears safe and achieves reasonable local control.
Item Description:Gesehen am 19.04.2021
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-021-83210-3

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