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IFN-γ represses IL-4 expression via IRF-1 and IRF-2

Polarization of CD4+ T helper cells toward either a Th1 or Th2 response can significantly influence host immunity to pathogens. IL-4 and IFN-γ are the signature cytokines of Th2 and Th1 cells, respectively. IFN-γ was shown to assist Th1 development by promoting IL-12 and IL-12 receptor expression. S...

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Main Authors: Elser, Bernd (Author) , Krammer, Peter H. (Author) , Li-Weber, Min (Author)
Format: Article (Journal)
Language:English
Published: 16 December 2002
In: Immunity
Year: 2002, Volume: 17, Issue: 6, Pages: 703-712
ISSN:1097-4180
DOI:10.1016/S1074-7613(02)00471-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1074-7613(02)00471-5
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761302004715
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Author Notes:Bernd Elser, Michael Lohoff, Sonja Kock, Marco Giaisi, Sabine Kirchhoff, Peter H. Krammer, and Min Li-Weber

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