Establishment of a secondary screening assay for P/Q-type calcium channel blockers

Development of calcium channel blockers is attractive, but has in the past been hampered by lack of high throughput electrophysiological technology. This limitation has been overcome by the implementation of automated patch clamp systems that allow identification of state-dependent compounds, which...

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Bibliographic Details

Main Authors:	Hermann, David (Author) , Mezler, Mario (Author) , Swensen, Andrew M. (Author) , Bruehl, Claus (Author) , Obergrußerger, Ali (Author) , Wicke, Karsten (Author) , Schoemaker, Hans (Author) , Gross, Gerhard (Author) , Draguhn, Andreas (Author) , Nimmrich, Volker (Author)
Format:	Article (Journal)
Language:	English
Published:	2013
In:	Combinatorial chemistry & high throughput screening Year: 2012, Volume: 16, Issue: 3, Pages: 233-243
ISSN:	1875-5402
DOI:	10.2174/1386207311316030008
Online Access:	Verlag: http://dx.doi.org/10.2174/1386207311316030008
Author Notes:	David Hermann, Mario Mezler, Andrew M. Swensen, Claus Bruehl, Ali Obergrußerger, Karsten Wicke, Hans Schoemaker, Gerhard Gross, Andreas Draguhn and Volker Nimmrich