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Germline BRCA1/2 mutations and severe haematological toxicities in patients with breast cancer treated with neoadjuvant chemotherapy

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Background - BRCA1 and BRCA2 play a central role in DNA repair. Therefore, patients harbouring germline (g) BRCA1/2 mutations (m) treated with chemotherapy might be at higher risk of haematological toxicities. - Methods - Patients from German Breast Group (GBG) and Arbeitsgemeinschaft Gynäkologisch...

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Main Authors: Furlanetto, Jenny (Author) , Möbus, Volker (Author) , Schneeweiss, Andreas (Author) , Rhiem, Kerstin (Author) , Tesch, Hans (Author) , Blohmer, Jens-Uwe (Author) , Lübbe, Kristina (Author) , Untch, Michael (Author) , Salat, Christoph (Author) , Huober, Jens (Author) , Klare, Peter (Author) , Schmutzler, Rita (Author) , Couch, Fergus J. (Author) , Lederer, Bianca (Author) , Gerber, Bernd (Author) , Zahm, Dirk-Michael (Author) , Bauerfeind, Ingo (Author) , Nekljudova, Valentina (Author) , Hanusch, Claus (Author) , Jackisch, Christian (Author) , Link, Theresa (Author) , Hahnen, Eric (Author) , Loibl, Sibylle (Author) , Fasching, Peter A. (Author)
Format: Article (Journal)
Language:English
Published: 7 January 2021
In: European journal of cancer
Year: 2021, Volume: 145, Pages: 44-52
ISSN:1879-0852
DOI:10.1016/j.ejca.2020.12.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejca.2020.12.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804920314210
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Author Notes:Jenny Furlanetto, Volker Möbus, Andreas Schneeweiss, Kerstin Rhiem, Hans Tesch, Jens-Uwe Blohmer, Kristina Lübbe, Michael Untch, Christoph Salat, Jens Huober, Peter Klare, Rita Schmutzler, Fergus J. Couch, Bianca Lederer, Bernd Gerber, Dirk-Michael Zahm, Ingo Bauerfeind, Valentina Nekljudova, Claus Hanusch, Christian Jackisch, Theresa Link, Eric Hahnen, Sibylle Loibl, Peter A. Fasching
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Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1 by Meyer, Kerstin B. (Author) , Marmé, Frederik (Author) , Schneeweiss, Andreas (Author) , Sohn, Christof (Author) , Burwinkel, Barbara (Author) , Brenner, Hermann (Author) , Müller, Heiko (Author) , Arndt, Volker (Author) , Chang-Claude, Jenny (Author) , Rudolph, Anja (Author) , Seibold, Petra Beate (Author) , Hamann, Ute (Author) ,


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