Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization
A cDNA, recently cloned (by Krieg et al. (1998)) from mouse skin, was shown to encode a 12(R)-lipoxygenase. When expressed in HEK cells, the recombinant protein converted methyl arachidonate into the corresponding 12-HETE ester which was shown to be the R-enantiomer by chiral phase chromatography. N...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 March 1999
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| In: |
FEBS letters
Year: 1999, Jahrgang: 446, Heft: 1, Pages: 142-148 |
| ISSN: | 1873-3468 |
| DOI: | https://doi.org/10.1016/S0014-5793(99)00196-9 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1016/S0014-5793(99)00196-9 Verlag, lizenzpflichtig, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/S0014-5793%2899%2900196-9 
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| Verfasserangaben: | Peter Krieg, Malte Siebert, Andreas Kinzig, Rainer Bettenhausen, Friedrich Marks, Gerhard Fürstenberger |
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| 520 | |a A cDNA, recently cloned (by Krieg et al. (1998)) from mouse skin, was shown to encode a 12(R)-lipoxygenase. When expressed in HEK cells, the recombinant protein converted methyl arachidonate into the corresponding 12-HETE ester which was shown to be the R-enantiomer by chiral phase chromatography. Neither arachidonic acid nor linoleic acid were substrates for the recombinant protein. The structure of the 12(R)-lipoxygenase gene is unique among all animal lipoxygenases in that it is divided into 15 exons and 14 introns spanning approximately 12.5 kb. By interspecific backcross analysis, the 12(R)-lipoxygenase gene was localized to the central region of mouse chromosome 11. | ||
| 650 | 4 | |a Chromosomal localization | |
| 650 | 4 | |a Functional expression | |
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