Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes
The expression pattern, enzymatic activity, and products of 8-lipoxygenase (LOX) were analyzed in normal and neoplastic skin of NMRI mice. While barely detectable in normal epidermis, 8-LOX was transiently induced by 12-O-tetradecanoylphorbol-13-acetate and constitutively expressed in papillomas but...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 March 1999
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| In: |
Molecular carcinogenesis
Year: 1999, Jahrgang: 24, Heft: 2, Pages: 108-117 |
| ISSN: | 1098-2744 |
| DOI: | https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2744%28199902%2924%3A2%3C108%3A%3AAID-MC5%3E3.0.CO%3B2-R 
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| Verfasserangaben: | Friederike Bürger, Peter Krieg, Andreas Kinzig, Bärbel Schurich, Friedrich Marks, and Gerhard Fürstenberger |
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| 245 | 1 | 0 | |a Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes |c Friederike Bürger, Peter Krieg, Andreas Kinzig, Bärbel Schurich, Friedrich Marks, and Gerhard Fürstenberger |
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| 520 | |a The expression pattern, enzymatic activity, and products of 8-lipoxygenase (LOX) were analyzed in normal and neoplastic skin of NMRI mice. While barely detectable in normal epidermis, 8-LOX was transiently induced by 12-O-tetradecanoylphorbol-13-acetate and constitutively expressed in papillomas but not carcinomas obtained by the initiation-promotion protocol of mouse skin carcinogenesis. The product profile and chirality of both the native and the recombinant protein produced the S enantiomers of 8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (8-HETE) and 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE) as the main arachidonic acid- and linoleic acid-derived metabolites. As compared with normal epidermis, papillomas exhibited 25- and 4-fold elevated levels of 8-HETE and 9-HODE, respectively. However, the varying S to R ratios of 8-HETE and the predominance of 9(R)-HODE indicated that in addition to 8(S)-LOX, other enzymes yet to be defined may be involved in 8-HETE and 9-HODE production. The massive accumulation of both 8-HETE and 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE) point to a critical role of these LOX pathways in epidermal tumor development, in particular in the papilloma stage. Here we showed that 8- and 12-hydroperoxyeicosatetraenoic acids and 8- and 12-HETE induce chromosomal alterations in cycling primary basal keratinocytes. Mol. Carcinog. 24:108-117, 1999. © 1999 Wiley-Liss, Inc. | ||
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| 650 | 4 | |a clastogenic effects | |
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| 650 | 4 | |a multistage mouse skin carcinogenesis | |
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