Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
We have recently identified two different pathways of CD95-mediated apoptosis (Scaffidi, C., Fulda, S., Srinivasan, A., Feng, L., Friesen, C., Tomaselli, K. J., Debatin, K.-M., Krammer, P. H., and Peter, M. E. (1998) >EMBO J. 17, 1675-1687). CD95-mediated apoptosis in type I cells is initiated by...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 06, 1999
|
| In: |
The journal of biological chemistry
Year: 1999, Jahrgang: 274, Heft: 32, Pages: 22532-22538 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.274.32.22532 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.274.32.22532 Verlag, lizenzpflichtig, Volltext: https://www.jbc.org/article/S0021-9258(18)81573-3/abstract 
|
| Verfasserangaben: | Carsten Scaffidi, Ingo Schmitz, Jiping Zha, Stanley J. Korsmeyer, Peter H. Krammer, and Marcus E. Peter |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1755850042 | ||
| 003 | DE-627 | ||
| 005 | 20230428043032.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210423s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1074/jbc.274.32.22532 |2 doi | |
| 035 | |a (DE-627)1755850042 | ||
| 035 | |a (DE-599)KXP1755850042 | ||
| 035 | |a (OCoLC)1341405930 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Watzl, Carsten |e VerfasserIn |0 (DE-588)1076837557 |0 (DE-627)835380742 |0 (DE-576)175362297 |4 aut | |
| 245 | 1 | 0 | |a Differential modulation of apoptosis sensitivity in CD95 type I and type II cells |c Carsten Scaffidi, Ingo Schmitz, Jiping Zha, Stanley J. Korsmeyer, Peter H. Krammer, and Marcus E. Peter |
| 264 | 1 | |c August 06, 1999 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.04.2021 | ||
| 520 | |a We have recently identified two different pathways of CD95-mediated apoptosis (Scaffidi, C., Fulda, S., Srinivasan, A., Feng, L., Friesen, C., Tomaselli, K. J., Debatin, K.-M., Krammer, P. H., and Peter, M. E. (1998) >EMBO J. 17, 1675-1687). CD95-mediated apoptosis in type I cells is initiated by large amounts of active caspase-8 formed at the death-inducing signaling complex (DISC) followed by direct cleavage of caspase-3. In contrast, in type II cells very little DISC and small amounts of active caspase-8 sufficient to induce the apoptogenic activity of mitochondria are formed causing a profound activation of both caspase-8 and caspase-3. Only in type II cells can apoptosis be blocked by overexpressed Bcl-2 or Bcl-xL. We now show that a number of apoptosis-inhibiting or -inducing stimuli only affect apoptosis in type II cells, indicating that they act on the mitochondrial branch of the CD95 pathway. These stimuli include the activation of protein kinase C, which inhibits CD95-mediated apoptosis resulting in a delayed cleavage of BID, and the induction of apoptosis by the ceramide analog C2-ceramide. In addition, we have identified the CD95 high expressing cell line BoeR as a CD95 apoptosis-resistant type II cell that can be sensitized by treatment with cycloheximide without affecting formation of the DISC. This also places the effects of cycloheximide in the mitochondrial branch of the type II CD95 pathway. In contrast, c-FLIP was found to block CD95-mediated apoptosis in both type I and type II cells, because it acts directly at the DISC of both types of cells. | ||
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 700 | 1 | |a Peter, Marcus E. |e VerfasserIn |0 (DE-588)1226267459 |0 (DE-627)1747245046 |0 (DE-576)165478187 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of biological chemistry |d [Amsterdam] : Elsevier B.V., 1905 |g 274(1999), 32, Seite 22532-22538 |h Online-Ressource |w (DE-627)269247025 |w (DE-600)1474604-9 |w (DE-576)077883837 |x 1083-351X |7 nnas |a Differential modulation of apoptosis sensitivity in CD95 type I and type II cells |
| 773 | 1 | 8 | |g volume:274 |g year:1999 |g number:32 |g pages:22532-22538 |g extent:7 |a Differential modulation of apoptosis sensitivity in CD95 type I and type II cells |
| 856 | 4 | 0 | |u https://doi.org/10.1074/jbc.274.32.22532 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jbc.org/article/S0021-9258(18)81573-3/abstract |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210423 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 1226267459 |a Peter, Marcus E. |m 1226267459:Peter, Marcus E. |d 50000 |e 50000PP1226267459 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1755850042 |e 3915103772 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Carsten Scaffidi, Ingo Schmitz, Jiping Zha, Stanley J. Korsmeyer, Peter H. Krammer, and Marcus E. Peter"]},"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"August 06, 1999"}],"id":{"doi":["10.1074/jbc.274.32.22532"],"eki":["1755850042"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"title":[{"subtitle":"JBC","title":"The journal of biological chemistry","title_sort":"journal of biological chemistry"}],"corporate":[{"display":"American Society for Biochemistry and Molecular Biology","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"recId":"269247025","note":["Gesehen am 19.05.2021"],"disp":"Differential modulation of apoptosis sensitivity in CD95 type I and type II cellsThe journal of biological chemistry","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"7","volume":"274","text":"274(1999), 32, Seite 22532-22538","pages":"22532-22538","issue":"32","year":"1999"},"titleAlt":[{"title":"JBC online"},{"title":"JBC"}],"pubHistory":["1.1905/06 -"],"name":{"displayForm":["publ. by the American Society for Biochemistry and Molecular Biology"]},"id":{"issn":["1083-351X"],"zdb":["1474604-9"],"eki":["269247025"]},"origin":[{"publisherPlace":"[Amsterdam] ; Baltimore, Md. [u.a.] ; Bethesda, Md.","dateIssuedDisp":"2021-","publisher":"Elsevier B.V. ; American Soc. of Biological Chemists ; ASBMB Publications","dateIssuedKey":"2021"}],"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"family":"Watzl","given":"Carsten","display":"Watzl, Carsten","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Peter H.","family":"Krammer","role":"aut","roleDisplay":"VerfasserIn","display":"Krammer, Peter H."},{"role":"aut","display":"Peter, Marcus E.","roleDisplay":"VerfasserIn","given":"Marcus E.","family":"Peter"}],"title":[{"title_sort":"Differential modulation of apoptosis sensitivity in CD95 type I and type II cells","title":"Differential modulation of apoptosis sensitivity in CD95 type I and type II cells"}],"note":["Gesehen am 23.04.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1755850042"} | ||
| SRT | |a WATZLCARSTDIFFERENTI0619 | ||