Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries: a cross-sectional study
Background - A sensitive and specific non-sputum-based test would be groundbreaking for the diagnosis of childhood tuberculosis. We assessed side by side the diagnostic accuracy of the urine-based lipoarabinomannan assays Fujifilm SILVAMP TB LAM (FujiLAM) and Alere Determine TB LAM Ag (AlereLAM) for...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
|
| In: |
The lancet. Infectious diseases
Year: 2021, Volume: 21, Issue: 3, Pages: 376-384 |
| ISSN: | 1474-4457 |
| DOI: | 10.1016/S1473-3099(20)30598-3 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1473-3099(20)30598-3 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1473309920305983 
|
| Author Notes: | Esin Nkereuwem, Toyin Togun, Marie P Gomez, Rita Székely, Aurélien Macé, Dawda Jobe, Samuel G Schumacher, Beate Kampmann, Claudia M Denkinger, and the Reach4KidsAfrica (R4KA) Consortium |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1755857810 | ||
| 003 | DE-627 | ||
| 005 | 20251101213506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210423s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S1473-3099(20)30598-3 |2 doi | |
| 035 | |a (DE-627)1755857810 | ||
| 035 | |a (DE-599)KXP1755857810 | ||
| 035 | |a (OCoLC)1341405971 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nkereuwem, Esin |e VerfasserIn |0 (DE-588)1238152856 |0 (DE-627)1765383676 |4 aut | |
| 245 | 1 | 0 | |a Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries |b a cross-sectional study |c Esin Nkereuwem, Toyin Togun, Marie P Gomez, Rita Székely, Aurélien Macé, Dawda Jobe, Samuel G Schumacher, Beate Kampmann, Claudia M Denkinger, and the Reach4KidsAfrica (R4KA) Consortium |
| 264 | 1 | |c 2021 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online December 11, 2020 | ||
| 500 | |a Gesehen am 04.08.2021 | ||
| 520 | |a Background - A sensitive and specific non-sputum-based test would be groundbreaking for the diagnosis of childhood tuberculosis. We assessed side by side the diagnostic accuracy of the urine-based lipoarabinomannan assays Fujifilm SILVAMP TB LAM (FujiLAM) and Alere Determine TB LAM Ag (AlereLAM) for detection of childhood tuberculosis. - Methods - In this cross-sectional study, we tested urine samples from children younger than 15 years with presumed pulmonary tuberculosis. Children were consecutively recruited from four dedicated outpatient childhood tuberculosis clinics in The Gambia, Mali, Nigeria, and Tanzania. Biobanked urine samples were thawed and tested using FujiLAM and AlereLAM assays. We measured diagnostic performance against a microbiological reference standard (confirmed tuberculosis) and a composite reference standard (confirmed and unconfirmed tuberculosis). Sensitivity and specificity were estimated with bivariate random-effects meta-analyses. - Findings - Between July 1, 2017, and Dec 1, 2018, we obtained and stored urine samples from 415 children. 63 (15%) children had confirmed tuberculosis, 113 (27%) had unconfirmed tuberculosis, and 239 (58%) were unlikely to have tuberculosis. 61 children were HIV-positive (prevalence 15%). Using the microbiological reference standard, the sensitivity of FujiLAM was 64·9% (95% CI 43·7-85·2; positive in 40 of 63 confirmed samples) and the sensitivity of AlereLAM was 30·7% (8·6-61·6; 19 of 63). The specificity of FujiLAM was 83·8% (95% CI 76·5-89·4; negative in 297 of 352 unconfirmed and unlikely samples) and the specificity of AlereLAM was 87·8% (79·0-93·7; 312 of 352). Against the composite reference standard, both assays had decreased sensitivity; the sensitivity of FujiLAM was 32·9% (95% CI 24·6-41·9; positive in 58 of 176 confirmed and unconfirmed samples) and the sensitivity of AlereLAM was 20·2% (12·3-29·4; 36 of 176). The specificity of FujiLAM was 83·3% (95% CI 71·8-91·7; negative in 202 of 239 unlikely samples) and the specificity of AlereLAM was 90·0% (81·6-95·6; 216 of 239). - Interpretation - By comparison with AlereLAM, FujiLAM showed higher sensitivity and similar specificity. FujiLAM could potentially add value to the rapid diagnosis of tuberculosis in children. - Funding - German Federal Ministry of Education and Research, the Global Health Innovative Technology Fund, the UK Research and Innovation Global Challenges Research Fund, and the UK Medical Research Council. | ||
| 700 | 1 | |a Togun, Toyin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gomez, Marie P |e VerfasserIn |4 aut | |
| 700 | 1 | |a Székely, Rita |e VerfasserIn |4 aut | |
| 700 | 1 | |a Macé, Aurélien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jobe, Dawda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schumacher, Samuel G |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kampmann, Beate |e VerfasserIn |4 aut | |
| 700 | 1 | |a Denkinger, Claudia M. |d 1978- |e VerfasserIn |0 (DE-588)131597701 |0 (DE-627)511279469 |0 (DE-576)298613727 |4 aut | |
| 700 | 1 | |a Abok, Ishaya Ibrahim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Angyu, Joshua Tsoukan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diakité, Aziz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diarra, Bassirou |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ebonyi, Augustine Odo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Egere, Uzochukwu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gomez, Marie P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jallow, Musa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Konate, Bakary |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lakda, Gonen Mato |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mahiga, Hellen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nkereuwem, Esin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ntinginya, Nyanda Elias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Olomi, Willyhelmina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sabi, Issa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saidy, Binta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sanogo, Moumine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sillah, Abdou K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sylla, Mariam |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The lancet. Infectious diseases |d New York, NY : Elsevier, 2001 |g 21(2021), 3, Seite 376-384 |h Online-Ressource |w (DE-627)34191200X |w (DE-600)2070985-7 |w (DE-576)121466701 |x 1474-4457 |7 nnas |a Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries a cross-sectional study |
| 773 | 1 | 8 | |g volume:21 |g year:2021 |g number:3 |g pages:376-384 |g extent:9 |a Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries a cross-sectional study |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S1473-3099(20)30598-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1473309920305983 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210423 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 131597701 |a Denkinger, Claudia M. |m 131597701:Denkinger, Claudia M. |d 910000 |d 911700 |d 50000 |e 910000PD131597701 |e 911700PD131597701 |e 50000PD131597701 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 9 | ||
| 999 | |a KXP-PPN1755857810 |e 3915143030 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","display":"Nkereuwem, Esin","family":"Nkereuwem","given":"Esin"},{"role":"aut","display":"Togun, Toyin","given":"Toyin","family":"Togun"},{"display":"Gomez, Marie P","role":"aut","given":"Marie P","family":"Gomez"},{"given":"Rita","family":"Székely","display":"Székely, Rita","role":"aut"},{"display":"Macé, Aurélien","role":"aut","family":"Macé","given":"Aurélien"},{"display":"Jobe, Dawda","role":"aut","family":"Jobe","given":"Dawda"},{"display":"Schumacher, Samuel G","role":"aut","given":"Samuel G","family":"Schumacher"},{"given":"Beate","family":"Kampmann","role":"aut","display":"Kampmann, Beate"},{"role":"aut","display":"Denkinger, Claudia M.","given":"Claudia M.","family":"Denkinger"},{"role":"aut","display":"Abok, Ishaya Ibrahim","family":"Abok","given":"Ishaya Ibrahim"},{"family":"Angyu","given":"Joshua Tsoukan","display":"Angyu, Joshua Tsoukan","role":"aut"},{"display":"Diakité, Aziz","role":"aut","given":"Aziz","family":"Diakité"},{"display":"Diarra, Bassirou","role":"aut","family":"Diarra","given":"Bassirou"},{"given":"Augustine Odo","family":"Ebonyi","role":"aut","display":"Ebonyi, Augustine Odo"},{"given":"Uzochukwu","family":"Egere","role":"aut","display":"Egere, Uzochukwu"},{"role":"aut","display":"Gomez, Marie P.","family":"Gomez","given":"Marie P."},{"role":"aut","display":"Jallow, Musa","given":"Musa","family":"Jallow"},{"role":"aut","display":"Konate, Bakary","family":"Konate","given":"Bakary"},{"role":"aut","display":"Lakda, Gonen Mato","given":"Gonen Mato","family":"Lakda"},{"family":"Mahiga","given":"Hellen","role":"aut","display":"Mahiga, Hellen"},{"role":"aut","display":"Nkereuwem, Esin","given":"Esin","family":"Nkereuwem"},{"role":"aut","display":"Ntinginya, Nyanda Elias","family":"Ntinginya","given":"Nyanda Elias"},{"given":"Willyhelmina","family":"Olomi","display":"Olomi, Willyhelmina","role":"aut"},{"family":"Sabi","given":"Issa","display":"Sabi, Issa","role":"aut"},{"role":"aut","display":"Saidy, Binta","given":"Binta","family":"Saidy"},{"role":"aut","display":"Sanogo, Moumine","family":"Sanogo","given":"Moumine"},{"family":"Sillah","given":"Abdou K.","role":"aut","display":"Sillah, Abdou K."},{"given":"Mariam","family":"Sylla","role":"aut","display":"Sylla, Mariam"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Available online December 11, 2020","Gesehen am 04.08.2021"],"id":{"doi":["10.1016/S1473-3099(20)30598-3"],"eki":["1755857810"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"2021"}],"name":{"displayForm":["Esin Nkereuwem, Toyin Togun, Marie P Gomez, Rita Székely, Aurélien Macé, Dawda Jobe, Samuel G Schumacher, Beate Kampmann, Claudia M Denkinger, and the Reach4KidsAfrica (R4KA) Consortium"]},"relHost":[{"id":{"zdb":["2070985-7"],"issn":["1474-4457"],"eki":["34191200X"]},"disp":"Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries a cross-sectional studyThe lancet. Infectious diseases","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"partname":"Infectious diseases","title":"The lancet","title_sort":"lancet"}],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2001 -"],"note":["Gesehen am 22.09.2021"],"part":{"year":"2021","text":"21(2021), 3, Seite 376-384","issue":"3","pages":"376-384","volume":"21","extent":"9"},"titleAlt":[{"title":"The lancet <London> / Infectious diseases"}],"recId":"34191200X","origin":[{"publisherPlace":"New York, NY ; London","dateIssuedKey":"2001","publisher":"Elsevier ; Lancet Publ. Group","dateIssuedDisp":"2001-"}]}],"physDesc":[{"extent":"9 S."}],"recId":"1755857810","title":[{"title_sort":"Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries","title":"Comparing accuracy of lipoarabinomannan urine tests for diagnosis of pulmonary tuberculosis in children from four African countries","subtitle":"a cross-sectional study"}]} | ||
| SRT | |a NKEREUWEMECOMPARINGA2021 | ||