(-)-Baclofen-induced and constitutively active inwardly rectifying potassium conductances in cultured rat midbrain neurons
Biophysical and pharmacological properties, and development of the (-)-baclofen-induced potassium (KBac) conductance and the constitutively active inwardly rectifying potassium (KIR) conductance were characterised using the patch-clamp technique in cultured embryonic rat midbrain neurons. KBac condu...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 1996
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| In: |
Pflügers Archiv
Year: 1996, Jahrgang: 433, Heft: 1, Pages: 49-57 |
| ISSN: | 1432-2013 |
| DOI: | 10.1007/s004240050247 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s004240050247
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| Verfasserangaben: | J.F.X. O’Callaghan, W. Jarolimek, A. Lewen, U. Misgeld |
MARC
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| 245 | 1 | 0 | |a (-)-Baclofen-induced and constitutively active inwardly rectifying potassium conductances in cultured rat midbrain neurons |c J.F.X. O’Callaghan, W. Jarolimek, A. Lewen, U. Misgeld |
| 264 | 1 | |c November 1996 | |
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| 520 | |a Biophysical and pharmacological properties, and development of the (-)-baclofen-induced potassium (KBac) conductance and the constitutively active inwardly rectifying potassium (KIR) conductance were characterised using the patch-clamp technique in cultured embryonic rat midbrain neurons. KBac conductance was induced by (-)-baclofen acting on γ-aminobutyric acid B (GABAB) receptors, and displayed a high degree of selectivity for potassium ions, an approximate square-root dependence of conductance on extracellular potassium concentration and strongly voltage-dependent activation. Ba2+ blocked the conductance in a voltage-independent manner, whereas Cs+ produced a voltage-dependent block. In the same preparation, the KIR conductance displayed biophysical properties indistinguishable from those of the KBac conductance. Block of KIR currents by Ba2+ was voltage independent (KI, 4 μM), whereas Cs+ produced a voltage-dependent block (KI, 370 μM at -100 mV, equivalent valence, z′, 1.67). The KBac and KIR conductances additionally displayed a strikingly similar pattern of development in culture; the specific conductance (nS/pF) of both conductances increased two- to three-fold between the first and second week in vitro, and remained constant thereafter. | ||
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