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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -...

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Bibliographische Detailangaben
Hauptverfasser: Sprick, Martin (VerfasserIn) , Weigand, Markus A. (VerfasserIn) , Krammer, Peter H. (VerfasserIn) , Walczak, Henning (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2000
In: Immunity
Year: 2000, Jahrgang: 12, Heft: 6, Pages: 599-609
ISSN:1097-4180
DOI:10.1016/S1074-7613(00)80211-3
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1074-7613(00)80211-3
Verlag, lizenzpflichtig, Volltext: https://www.cell.com/immunity/abstract/S1074-7613(00)80211-3
Volltext
Verfasserangaben:Martin R. Sprick, Markus A. Weigand, Eva Rieser, Charles T. Rauch, Peter Juo, John Blenis, Peter H. Krammer, and Henning Walczak

MARC

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520 |a Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signaling by the two death-inducing TRAIL receptors 1 and 2 (TRAIL-R1 and TRAIL-R2) are controversial. Analysis of the native TRAIL death-inducing signaling complex (DISC) revealed ligand-dependent recruitment of FADD/MORT1 and caspase-8. Differential precipitation of ligand-stimulated TRAIL receptors demonstrated that FADD/MORT1 and caspase-8 were recruited to TRAIL-R1 and TRAIL-R2 independently of each other. FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2. 
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