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Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background),...

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Main Authors: Frampton, Matthew (Author) , Silva Filho, Miguel Inacio da (Author) , Broderick, Peter (Author) , Thomsen, Hauke (Author) , Försti, Asta (Author) , Vijayakrishnan, Jayaram (Author) , Cooke, Rosie (Author) , Enciso-Mora, Victor (Author) , Hoffmann, Per (Author) , Nöthen, Markus Maria (Author) , Lloyd, Amy (Author) , Holroyd, Amy (Author) , Eisele, Lewin (Author) , Jöckel, Karl-Heinz (Author) , Ponader, Sabine (Author) , Pogge von Strandmann, Elke (Author) , Lightfoot, Tracy (Author) , Roman, Eve (Author) , Lake, Annette (Author) , Montgomery, Dorothy (Author) , Jarrett, Ruth F. (Author) , Swerdlow, Anthony J. (Author) , Engert, Andreas (Author) , Hemminki, Kari (Author) , Houlston, Richard S. (Author)
Format: Article (Journal)
Language:English
Published: 22 October 2013
In: Nature Communications
Year: 2013, Volume: 4, Pages: 1-7
ISSN:2041-1723
DOI:10.1038/ncomms3549
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms3549
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms3549
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Author Notes:Matthew Frampton, Miguel Inacio da Silva Filho, Peter Broderick, Hauke Thomsen, Asta Försti, Jayaram Vijayakrishnan, Rosie Cooke, Victor Enciso-Mora, Per Hoffmann, Markus M. Nöthen, Amy Lloyd, Amy Holroyd, Lewin Eisele, Karl-Heinz Jöckel, Sabine Ponader, Elke Pogge von Strandmann, Tracy Lightfoot, Eve Roman, Annette Lake, Dorothy Montgomery, Ruth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Kari Hemminki & Richard S. Houlston
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Summary:In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.
Item Description:Gesehen am 26.04.2021
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms3549

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